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Showing 1 to 12 of 12 for “"Human endogenous retrovirus"”.
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Reconstitution and Characterization of Human Endogenous Retrovirus-K
<p>Retroviruses are a family of clinically significant and scientifically fascinating viruses that infect a wide array of organisms from all vertebrate classes. The two hallmark events in the life cycle of retroviruses are the reverse transcription of the single stranded RNA (ssRNA) genome …
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Evidence of Human Endogenous Retrovirus K Involvement In Human Cancer
… population, as well as commercially available human cell lines for the presence of human endogenous retrovirus K (HERV-K) Env viral RNA (vRNA), protein, and viral particles. We hypothesize that HERV-K proteins are tumor-associated antigens and as such can be profiled and targeted in patients …
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The Detection and Role of Human Endogenous Retrovirus K (HML-2) In Rheumatoid Arthritis
Human endogenous retroviruses are the remnants of ancient retroviral infections present within our genome. These molecular fossils show similarities with present day exogenous retroviruses but act as typical Mendelian elements that are passed vertically between generations. Despite being repeatedly …
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Characterization of Human Endogenous Retrovirus sequences identifed in the human genome using the RetroTector software
Human Endogenous Retroviruses (HERVs) represent the inheritance of ancient germ-line cell infections by exogenous retroviruses and the subsequent transmission of the proviral integrated elements to the descendants. Actually, no replication-competent HERV sequence is recognizable in the human …
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Human Endogenous Retrovirus K As A Novel Tumor-Associated Antigen For Development of An Ovarian Cancer Vaccine
<p><strong>HUMAN ENDOGENOUS RETROVIRUS K AS A NOVEL TUMOR-ASSOCIATED ANTIGEN FOR DEVELOPMENT OF AN OVARIAN CANCER VACCINE </strong><em></em></p> <p>Publication No.________<br />Kiera Rycaj, B.S.<br />Supervisory Professor: Feng Wang-Johanning, Ph.D., M.D.</p> <p>Ovarian cancer (OC) is the fourth …
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Characterization of The Role(S) of Env Protein of Human Endogenous Retrovirus-K In Multiple Human Cancers
<p>Human endogenous retroviruses (HERVs) are remnants from ancient retroviral infections, and most of them are inactive in normal tissues. One family of HERV, HERV-K, is found to be associated with multiple human cancers including breast cancer, pancreatic cancer and melanoma, but the causal …
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The role of Human Endogenous Retrovirus K10 (HERV-K10) in the pathogenesis of rheumatoid arthritis via molecular mimicry
… pathogens are considered contributory factors. Human endogenous retrovirus K10 (HERV-K10) is one such virus as it retained the capacity to produce viral particles in RA synovium. This study set out to explore how HERV-K10 Gag matrix region could contribute to RA pathogenesis and perpetuation, …
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Characterization of the human endogenous retrovirus HERV-‐K(HML-‐6) and HERV-‐K(HML-‐10) sequences and analysis of their expression
It has been estimated that 8% of human genome is composed of sequences originating from exogenous retroviruses that infected the germ line cells over millions of years and are termed human endogenous retroviruses (HERVs). After germ line infection, the retroviral DNA was integrated into the genome …
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Generation of Transgenic Mice to Evaluate Promoter Activity and Specificity of Two Human Endogenous Retrovirus Long Terminal Repeats = Untersuchungen zur Promotor-Aktivität und -Spezifität von zwei Long Terminal Repeats humaner endogener Retroviren in transgenen Mäusen
… Promoter Activity and Specificity of two Human Endogenous Retrovirus Long Terminal Repeats Human Endogenous Retrovirus Long Terminal Repeats (HERV-LTRs) comprise 1.8% of the human genome (52.7 Mb). These sequences contain all the signal structures necessary for the regulation of gene …
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Expression and Immunological Characterization of Herv-K Transmembrane Envelope Protein In Human Breast Cancer
<p>The human endogenous retrovirus K (HERV-K) <em>env</em> gene encodes envelope protein comprising surface (SU) and transmembrane (TM) domains. Having shown the exclusive expression of SU in human breast cancer and the stimulation of SU-specific immune responses in patients with breast cancer, our …
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Transcriptional Heterogeneity in ALS: Patients with Retrovirus-mediated Disease and Potential Cell-type Specific Therapeutic Approaches
… (DEA) revealed that certain loci associated with human endogenous retrovirus K (HERV-K), a type of transposable element (TE), as well as other non-TE features were dysregulated in patient samples compared to controls. In both the CTX and SC, around 20% of ALS patients had higher overall HERV-K …
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Targeting An Ancient Retrovirus During Melanoma Using Adoptive T Cells Therapy
… for melanoma we targeted a TAA derived from human endogenous retroviruses (HERV), whose genome stably integrated into humans millions of years ago. During oncogenesis, biologically active variants of HERV, such as the envelope (env) protein of HERV-K, are expressed on the surface of melanoma, …