Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Human coronavirus"”.
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Human coronavirus NL63 envelope protein-protein interactions: role in pathogenesis
Human coronaviruses (HCoVs) have garnered intense interest due to the large outbreaks caused by severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1), Middle East respiratory syndrome coronavirus (MERS-CoV), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which have …
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Antibody production with synthetic peptides against human Coronavirus-NL63 ORF3 protein
Human Coronavirus (HCoV) NL63 was detected in an infant in the Netherlands in 2004 and will hereafter be referred to as CoV-NL63. Four years later, it was classified into Group 1 coronaviruses by the International Committee for Taxonomy of Viruses (ICTV), which was modified into alphacoronavirus in …
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A reverse genetics study of the Human Coronavirus 229E ADP-ribose-1"-phosphatase
Coronaviruses have extremely large RNA genomes and use complex regulatory mechanisms to replicate and express their genomes. This involves the expression of two large polyproteins, pp1a and pp1ab, that are autoproteolytically processed to produce nonstructural proteins (nsp) 1 to 16. In this study, …
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Cloning and expression of the M-gene from the human coronavirus NL-63 in different expression systems
… (e.g. rhino-, influenza-, parainfluenza, human metapneumo-, respiratory syncytial-, adeno- and coronaviruses), the cause of a substantial portion, (48-70%) of cases remain unidentified (Van der Hoek et al, 2004; Fouchier et al, 2004; File, 2003; Fine et al, 1999; Shay et al, 1999, …
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The burden of human coronavirus infection in children hospitalized with severe lower respiratory tract infection in Cape Town, South Africa (2012-2013)
… better understand the epidemiology and burden of human coronaviruses - NL63, HKU1, OC43 and 229E in South Africa, their role in the aetiology of childhood pneumonia needs to be described. Methods: We used data collected between September 2012 – September 2013 from children aged < 13 years with …
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A Study of Human Coronavirus NL63: Characterization of Virus Replication, Targeting of Papain-Like Protease 2 by Antivirals and Probing Virus Mediated Innate Immune Antagonism
<p>Acute respiratory tract infections in humans are responsible for significant morbidity and mortality especially in children, elderly, and the immunocompromised. Virus infection is the primary cause of acute respiratory tract infections. Infection with coronaviruses can cause disease ranging from …
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Host Entry Factors for Human Coronaviruses
<p>Coronaviruses infect a diverse range of animals from birds to pigs and cats to humans. Coronaviruses employ RNA-based replicative processes and as such are genetically adaptable to acquire novel host ranges. A coronavirus from one species can jump to another by shifting its entry requirements. …
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Coronavirus Replication Inhibition by Herbal Extracts
Coronaviruses are plus-stranded RNA viruses that infect human and large variety of animals, including pig, cattle, dog, rat, rabbit, turkey, and bird. Human coronavirus has been known to cause common colds and perhaps gastroenteritis. Animal coronaviruses cause gastroenteritis, hepatitis, and a …
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Host heterogeneity and respiratory disease dynamics: From structural inequity to immune history
… explored in ecology and evolution. However, in human populations, social inequity remains underexplored as a source of heterogeneity despite having long been identified as a threat to global health and infectious disease control. In this work, we draw from established ecological frameworks such …
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Symptom Experience and Influenza-Like Illness in a Military Population
… clinical characteristics of strain specific coronavirus. Finally, examine the psychometric properties of the Canadian Acute Respiratory Illness and Flu Scale (CARIFS).</p> <p>BACKGROUND: ILI outbreaks have been a significant source of non-battle injury among military personnel. Many different …
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Identification of potential pathogens of pneumonia in sputum samples from adult patients at the University Teaching Hospital in Lusaka
… 71% of the 146 samples tested using PCR yielded human cytomegalovirus 24.3% (44/181), K. pneumoniae 17.7% (32/181), H. influenzae non-type b 16.0% (29/181), S. pneumoniae and S. aureus 9.4% (17/181) each. Other agents, which included Rhinovirus (5.5%, 10/181), M. catarrhalis (4.4%, 8/181), …
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Identification of potential pathogens of pneumonia in sputum samples from adult patients at the University Teaching Hospital in Lusaka
… 71% of the 146 samples tested using PCR yielded human cytomegalovirus 24.3% (44/181), K. pneumoniae 17.7% (32/181), H. influenzae non-type b 16.0% (29/181), S. pneumoniae and S. aureus 9.4% (17/181) each. Other agents, which included Rhinovirus (5.5%, 10/181), M. catarrhalis (4.4%, 8/181), …
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Dissecting the Novel Roles of TRIM56 in Antiviral Innate Immunity
… (YFV), dengue virus serotype-2 (DENV2), and human coronavirus virus (HCoV)-OC43. Moreover, I demonstrate that TRIM56’s anti-flavivirus effects required both the E3 ligase activity that lies in the N-terminal RING domain and the integrity of its C-terminal portion, while the restriction of …
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INFECTION- AND VACCINE-INDUCED IMMUNE RESPONSES TO SARS-COV-2 AND OTHER HUMAN CORONAVIRUSES
SUMMARY Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in December 2019 and spread across the world causing the COVID-19 pandemic. Unprecedented efforts by scientists across the world saw the development and approval of different mRNA and adenovirus-vectored vaccines targeting …
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Studies on severe acute respiratory syndrome coronavirus type -2 in Northern South Africa
… of the Coronaviridae family into the human population, causing severe respiratory disease with increased morbidity rates. A dearth of information exists on human coronavirus (HCoV) molecular epidemiology, and circulation in different populations in Africa. As the COVID-19 pandemic …