Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 21 for “"Human colorectal cancer"”.
-
Functional genomic analysis of PPAR-gamma in human colorectal cancer cells
… a chemopreventative and therapeutic target for colorectal cancer. Activation of PPAR-gamma by thiazolidinediones (TZDs) inhibits proliferation and induces differentiation in human colon cancer cells. RS5444, a novel TZD, is a high affinity and high specificity ligand for PPAR-gamma. We have …
-
The effect of RAN inhibition on human colorectal cancer cells (CRC)
Colorectal cancer (CRC) is the third most widespread and fourth most fatal malignancy disease. The CRC from a primary site can spread to other tissues, forming secondary tumours. CRC can metastasise to the liver through the effect of K-Ras and Pten mutation (Mt.) (Abbas et al. 2020). This study …
-
Synergistic anti-cancer effects of capsaicin and 3,3'-diindolylmethane in human colorectal cancer, involvement of p53 and NF-kB
Cancer is the second leading cause of death in the United States and a leading cause of morbidity and mortality worldwide. A promising area of cancer research is focused on chemoprevention by nutritional compounds. Epidemiological studies have shown a strong negative correlation between fruit, …
-
Novel nanoparticle drug delivery systems: application in the in vitro study of Bisnaphthalimidopropyl derivatives against human colorectal cancer cell lines.
Colorectal cancer is one of the most severe causes of mortality worldwide accounting for 10% of total cancer cases. Although recent advances in early diagnosis have reduced the mortality rate associated with CRC, patients suffering from the later metastatic stage of the disease have a 5-year …
-
Regulation of apoptosis in human cancer cells
Nitric oxide is postulated to protect cancer cells from the death-inducing effects of tumour necrosis factor alpha by S-nitrosating the active site cysteines, inhibiting cleavage of caspase-9. We aimed to test this hypothesis and to determine its validity across cancer cell types. In addition, we …
-
Characterisation of the Helix pomatia agglutinin binding glycoproteins of colorectal cancer cell lines and tissue samples
Colorectal cancer (CRC) is one of the most common malignancies in the US and Western Europe and metastatic dissemination after CRC is a leading cause of mortality. New markers predictive of cancer cell behaviour are actively sought both as targets and as a means of predicting patient prognosis. The …
-
Production, characterization and evaluation of the chemotherapeutic and immunogenic potential of protein based virus-like particles in tumoral and immune cell lines
… a more accentuated decrease on cell viability of human colorectal cancer cells whether compared with non-decorated particles. In conclusion, this work present the full production and characterization of three distinct nanoplatforms and a solid in vitro evaluation of a range of cell mechanisms such …
-
Cancer cell behaviour following parasite exposure
… are estimated to cause 16.1% of global cancer cases. While certain helminths are conclusive causes of cancer, others have been shown to reduce the disease. It is currently unknown why differing helminth infections promote or prevent cancer development and progression, or which cellular …
-
DNA polymerase beta inhibitor pamoic acid : toxicity to metakaryotic human cancer stem cells (HT-29)
… other events, are also the stem cells of precancerous, cancerous and metastatic lesions of carcinogenesis. Furthermore, our lab has discovered that metakaryotic stem cells, both in fetal development and tumor growth, use a peculiar mode of DNA synthesis and segregation that involves inter …
-
Microfluidic-based Fluorescence Detection for Biomarker Analysis
… platform. After validation, DiFi EVs (from DiFi human colorectal cancer cell line) were labeled with a membrane dye (Anepps) and Phycoerythrin (PE)-tagged antibodies (3 common tetraspanin markers, including CD9, CD63 and CD81 and epidermal growth factor receptor (EGFR)). Based the colocalization …
-
Genomic analysis in human solid tumours:Copper Homeostasis Genes in Colorectal cancer
… have been discussed: 1. The public database: Cancer Genome Atlas Network has been consulted in order to reveal the presence of somatic mutations in copper homeostasis genes (CHGs) in colorectal cancer, and such analysis, performed on 228 colorectal tumor samples, has revealed that inactivating …
-
DISSECTING THE ROLE OF NEDD4 HECT E3 LIGASE AND ITS ISOFORMS IN CANCER
… and subsequent PTEN degradation in human colorectal cancer. Since NEDD4 is overexpressed in Non-Small Cell Lung cancer (NSCLC), and high percentage of these tumors show K-RAS mutation, we decided to verify the proto-oncogenic role of NEDD4 in a genetic context characterized by K-RAS …
-
Inhibitory potential of anthocyanins and anthocyanin-rich extracts on colorectal cancer progression through apoptosis, angiogenesis, and immune response effects
Colorectal cancer is a relentless disease plaguing over one million people just in the United States. Survival rates are highly dependent on the stage of malignancy, with a low survival rate once the cancer has metastasized. Therefore, it is crucial to understand the molecular changes that occur …
-
Identification of a new tumor suppressor pathway modulating rapamycin sensitivity in colorectal cancer
… alterations to gene expression are implicated in cancer development. Epigenetic repression of gene transcription through DNA methylation is one of the fundamental mechanisms for inactivation of tumor suppressor genes in many cancers. Thus, identification of these silencing tumor suppressor genes …
-
Identification of determinants of sensitivity to duocarmycin analogues: A class of potent anti-cancer drugs
… antibody-drug conjugates for the treatment of cancer. Although the mechanism of action (MOA) of duocarmycins has been elucidated as DNA minor groove alkylation, not much is known about the factors involved in the intrinsic sensitivity of cancer cells to duocarmycins. This thesis aims to …
-
Importance of the Gastrin N-Terminal Region in Binding and Activation of the Putative G17-Gly Receptor on Human Colonic Carcinoma Cells
… gastrin processing intermediate receptor(s) on human colorectal cancer cells is investigated. The C-terminal sequence Trp-Met-Asp-Phe-NH2 has long been recognized to be essential to the binding and activation of CCK2-R by G17. However, research in our laboratory has indicated that the N-terminal …
-
RNA Interference and cyclooxygenase-2 (COX-2) regulation in colon cancer cells
… methods and combined strategies, conventional cancer chemotherapy still lacks specificity and induces drug resistance. Gene therapy can offer the potential to obtain the success in the clinical treatment of cancer and this can be achieved by replacing mutated tumour suppressor genes, inhibiting …
-
Advancements in genome engineering and applications in mammalian systems
… transcription factor (TF) with a 3xFLAG tag in a human colorectal cancer cell line (HCT116). I genotyped modified clones to confirm the precise tag insertion. The TF binding motifs, typical peak locations and peak calling enrichment were validated from ChIP-seq results. Similar analyses and …
-
3D Cell Culture in Microgels: A Novel Screening Platform for Disease Modelling and Drug Testing
Cancer is the second leading cause of deaths in the world with colon cancer being one of the deadliest types of cancer. However, only 7% of new anti-cancer drugs make it through clinical trials and are brought to the market. This low success rate has been attributed to a lack of relevant cancer …
-
Anti-inflammatory and anti-colon cancer potential of yerba mate (Ilex paraguariensis St. Hilaire) bioactive constituents
… saponins that have been associated with cancer prevention. However, which constituents of yerba mate are involved in the protective effects against colon carcinogenesis is not clearly understood. The objective of this study was to evaluate the dietary prevention of colon carcinogenesis by …
Page 1 of 2