Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Human chromosomes"”.
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Human chromosomes: structure, abnormalities and birth defects
… four papers that revolve around the structure of human chromosomes and their relationship to birth defects. A new technique is described to produce spiralization of human metaphase chromosomes. The important feature is heat followed by trypsin treatment. By varying conditions, it is possible to …
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The distribution and localization of drug-induced secondary constrictions in human chromosomes
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Chromosome dynamics and genomic instablity in neuroblastoma. Three genomic pillars: MYCN amplification, numerical and structural changes.
… and that they are preferentially anchored to human chromosomes at sites adjacent to the telomeres, resulting in a random segregation pattern of DMs to post-mitotic neuroblastoma cells. Furthermore, by making human/murine hybrids we showed that DMs do not bind to specific positional elements in …
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Optimization of Cytogenetic and Physical mapping of Culicinae genomes
… Culex genomes, the structure of their polytene chromosomes is damaged by ectopic contacts that make the analysis difficult. Mitotic chromosomes from imaginal discs of 4th instar larvae of Aedes aegypti were tested as a source for the physical genome mapping for this mosquito. Chromosomes in …
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Defining Multiple Steps in Human Telomere End Processing
… involved. We here define these steps in normal human cells. We show the final lagging RNA primer is positioned ~70-100 nt from chromosome ends (not at the extreme ends), and is not removed for ~1hr following replication. Therefore, the location of the RNA primer, rather than its size, is a …
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Genome visualisation and user studies in biologist-computer interaction
… representations of the rat, the mouse, and the human chromosomes, and can easily be used for other genomes. In the context of VisGenome development we made the following research contributions. We developed a new algorithm (CartoonPlus) which allows the users to see different kinds of data in …
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Causes and Consequences of Genomic Instability in Prostatic Carcinogenesis
… contributor. Telomeres are the terminal ends of human chromosomes, and when dysfunctional can lead to break-fusion-bridge cycles and multi-polar mitoses that generate numerical and structural chromosomal instability. The results presented reinforce the association of telomere dysfunction with the …
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Nucleic acid clamp-mediated transcriptional and translational modulation of oncogenes via the stabilization of G-quadruplexes
… 1 kb from transcriptional start sites across all human chromosomes in addition to at telomeric regions. Extensive efforts from many research groups have been dedicated to targeting G4s in oncogenic promoters, telomeres, and 5’-UTRs with traditional small molecules. However, most small molecules …
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Genome-Wide and Multi-Scale Mapping of DNA Supercoiling in Differentiating Human Stem Cells
… of every cell is encoded in its genome. Human cells must organise and compact their genetic material at multiple levels to accommodate the two-meter-long DNA within the confined nuclear space of six microns. Chromatin folding is not only a cellular need, but is also crucial for gene …
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Physical and genetical investigation of the Xp11.3 region on the short arm of the human X-chromosome
The pattern of inactivation in the DXS8237E-UBE1-PCTK1 region is of particular interest, since the mechanisms of X chromosome inactivation and the escape from inactivation are, as yet, not fully understood. The inactivation status of the DXS8237E and PCTKl gene differ: the first undergoes normal …
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Chromosomes and spermatozoa of the great apes and man
… banding techniques and compared to the human chromosome comple¬ ment. This has shown remarkable homologies between species, and presumed mechanisms of chromosome evolution have been proposed. Chromosome heteromorphisms in the great apes have been compared to those found in human …
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Generation of a human gene index and its application to disease candidacy
… provided the impetus for developing a STACK human gene index, also referred to as a whole-body index. In this dissertation, I report on the development of a STACK human gene index represented by consensus transcripts where all constituent ESTs sample single or multiple tissues in order to …