Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 43 for “"Human bone marrow"”.
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Self-renewal of human bone marrow-derived hematopoietic stem cells in vitro.
Self-renewal of human bone marrow-derived hematopoietic stem cells in vitro.
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The effects of fibroblast growth factor-2 om human bone marrow cells
Bibliography: leaves 163-191.
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Role of Wnt signaling in proliferation of human bone marrow-derived mesenchymal stem cells
Human mesenchymal stem cell (hMSC) is an attractive source of adult stem cells for the therapeutic use in regenerative medicine. These cells are usually culture expanded prior to their application. However, their proliferation and differentiation potential were gradually decreased during in vitro …
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Comprehensive Proteomic Analysis and Characterization of Human Bone Marrow Mesenchymal Stem/Stromal Derived Extracellular Vesicles
… effector in therapeutic responses produced by human mesenchymal stromal/stem cells (hMSCs). As the hMSC-EV regenerative capacity is mainly ascribed to the transfer of proteins and RNA composing the EV cargo and to the activity attributed by the protein surface markers, we sought to profile the …
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Protective effects of Human Bone Marrow-Derived Mesenchymal Stem Cells on Apoptosis Induced Human Neuroblastoma SH-SY5Y Cells
… disease and stroke. Cell therapy using human bone marrow-derived mesenchymal stem cells (hMSCs) is an attractive tool to alleviate neurological disease We investigate whether culture media of hMSCs and coculted hMSC using by transwell have effects against apoptosis induced SH-SY5Ys. …
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Multi-Niche Human Bone Marrow On-A-Chip for Studying the Interactions of Adoptive Cell Therapies with Multiple Myeloma
Multiple myeloma (MM), a cancer of bone marrow-resident plasma cells, is the 2nd-most common hematological malignancy. However, despite the advent of immunotherapies like chimeric antigen receptor (CAR) -T cells, which gained FDA approval in March 2021, relapse is nearly universally inevitable. The …
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Effect of platelet factors and thrombin on multiplication of human bone marrow mesenchymal stem cells cultured in low and high oxygen level in vitro
<p>Background: In the bone marrow, hematopoietic and mesenchymal stem cells form a unique niche, in which oxygen tension is low. Hypoxia may have a role in maintaining stem cell capacity for self-renewal and multipotency. We have shown previously a positive influence of platelet-derived growth …
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Novel insights into megakaryopoiesis, thrombopoiesis and acute coronary thrombosis: transcriptome profiling of the haematopoietic stem cell, megakaryocyte and platelet
… project was to investigate the transcriptome of human haematopoietic stem cells (HSCs), megakaryocytes and platelets to gain insights into steady state and accelerated thrombopoiesis that occurs in states of haemostatic demand and in thrombosis by applying these findings to the pathological …
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Novel Characteristics of Murine Bone Marrow-Derived Macrophages and Human Macrophage-Like Cells
… for novel properties of macrophages derived from bone marrow stem cells. In study 1, treatment of activated mouse bone marrow-derived macrophages (BMM) with either catecholamine synthesis inhibitors (α-methyl-para-tyrosine and fusaric acid) or the β2 adrenergic receptor antagonist ICI 118,551 …
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Tracing of Alpha-to-Beta Cell Transition Following Treatment with CHIR-Injected Human Multipotent Stromal Cell Secreted Proteins
… Previous work from the Hess Lab has shown that human bone marrow-derived multipotent stromal cells (BMMSCs), bioengineered via WNT pathway activation (CHIR+ conditioned media; CM), secrete factors that promote beta-cell recovery in streptozotocin (STZ) treated NOD/SCID mice. Here, we …
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Developing a model to assess the contribution of cytokeratin 19-expressing cells during multipotent stromal cell-induced islet regeneration
… pharmacological activation of Wnt-signaling in human bone marrow-derived multipotent stromal cells (hMSC) generated conditioned media (CM) that promoted β-cell regeneration in streptozotocin-treated mice. Ductal-derived endocrine progenitors, which have been shown to generate β-cells following …
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Molecular substrate design for the selective adhesion, proliferation and differentiation of marrow connective tissue progenitors
… of connective tissue progenitors (CTPs) from human bone marrow aspirates. The basic premise of the thesis is that integrin-specific adhesion peptides, when presented in a biophysically appropriate spatial arrangement against an inert background, allow enrichment of CTPs in vitro. Comb …
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Žmogaus mezenchiminių kamieninių ląstelių genetinių savybių tyrimas saugiai terapijai užtikrinti /
Human mesenchymal stem cell (MSC) therapy holds promise for treating degenerative and immune system diseases and repair of damaged tissues. Human tissues are cryopreserved and isolated MSCs are expanded in various culture media when prepared for clinical applications. These manipulations can …
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Investigation of human mesenchymal stem cell genetic characteristics to ensure therapy safety /
Human mesenchymal stem cell (MSC) therapy holds promise for treating degenerative and immune system diseases and repair of damaged tissues. Human tissues are cryopreserved and isolated MSCs are expanded in various culture media when prepared for clinical applications. These manipulations can …
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Neuroprotective Effect of Human Mesenchymal Stem Cell on Dopaminergic Neurons by Anti-inflammatory Action
… PD. The present study was to evaluate effect of human bone marrow-derived mesenchymal stem cell (hMSCs) on modulation of neuroinflammation. We used lipopolysaccharide (LPS)-induced in vitro and in vivo inflammation models to investigate whether hMSCs have a protective effect on the dopaminergic …
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Investigating The Role of Exosomal Communication In The Glioma Microenvironment
<p>Evidence indicates that human cancers are maintained by a population of cells with stem-like properties called cancer stem cells (CSCs). However, the influence of the surrounding stromal cells on the behavior of the CSCs remains poorly understood. We have recently shown that the …
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Discovering bioactive compounds for bone growth: the osteogenicity of marine organism-derived extracts
… marine-organism derived osteogenic (promoting bone formation) activity, using extracts produced from a wide range of taxonomic groups sourced from the west coast of Ireland. In total, 100+ extracts were screened <i>in vitro</i> for their osteogenic potential, using both a human foetal …
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Characterization of human myeloid progenitors and their differentiation
… of this thesis was to further characterize early human myeloid development. As a first step we established a map over neutrophil and erythroid differentiation-associated changes both on the surface and in gene expression, using in vitro cultures of normal human bone marrow cells. This map …
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Integrin α2 and Akt in early hematopoiesis
… progenitor cells both in mouse and human, enabling further characterization of these cell populations not only in normal hematopoiesis, but also in various hematological malignancies. However, while the isolation of different cell populations in mouse hematopoietic system is achieved …
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Tissue Engineering the TMJ Condyle using Human Umbilical Cord Mesenchymal Stromal Cells
… TMJ disorder pathologies. Prior to this thesis, human umbilical cord mesenchymal stromal cells (hUCMSCs), identified as multipotent cells only in this decade, had not yet been used for TMJ tissue engineering. Hence, this thesis proposed a revolutionary tissue engineering approach in which hUCMSCs …
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