Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Human astrocytoma"”.
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A systems approach to the different grades and progression of human astrocytoma
Astrocytomas are the most common glioma, accounting for about half of all primary brain and spinal cord tumors. Malignancy in these tumors ranges from the least aggressive pilocytic astrocytoma (WHO grade 1) to the most aggressive glioblastoma (WHO grade 4). Molecular biomarkers or signatures—i.e., …
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Investigation of aspects of reactive gliosis in human astrocytoma cell lines:application for toxicity assessment
… toxicity assay that is more relevant to the human response than existing animal cell based models, the U251-MG, U373-MG and CCF-STTG 1 human astrocytoma cell lines were investigated for their ability to exhibit reactive-like changes following exposure to ethanol, chloroquine diphosphate, …
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Molecular mechanisms of cadmium toxic
… etiology of cadmium-induced toxicity in three human cell lines: HepG2 (human hepatoma), 1321N1 (human astrocytoma) and HEK 293 (human embryonic kidney) cell lines after 24hrs exposure to 5, 10 and 50 μM cadmium chloride (CdCl₂). The role of the Nrf2-Keap1-ARE pathway in the adaptive response of …
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Evaluation of the mechanisms of neurotoxcity using metabolomic strategies
There are many neurotoxic substances that affect humans. Cobalt and mephedroneare examples of neurotoxic compounds with little known about their mode of action.Cobalt neurotoxicity was investigated in human astrocytoma and neuroblastoma cellsusing proliferation assays coupled with LC-MS based …
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Neural Stem Cells in Brain Tumor Development
Malignant astrocytomas are highly invasive and incurable brain tumors. Mouse models that genetically resemble the human disease are valuable tools in understanding the pathogenesis of these malignancies. We previously reported mouse models based on conditional inactivation of the human …
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Characterizing and analyzing disease-related omics data using network modeling approaches
… characterize aggressiveness and heterogeneity of human astrocytoma, the most common glioma with a strikingly high mortality rate. A large-scale global gene expression analysis was performed to analyze gene expression profiles representing hundreds of samples generated by oligonucleotide …
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Transcriptome activity of human cytomegalovirus (strain Merlin) in fibroblasts, epithelial cells and astrocytes
Global human cytomegalovirus (HCMV) gene expression was investigated during replication in three permissive human cell types in tissue culture; human foetal foreskin fibroblasts (HFFF-2), human retinal pigmented epithelial (RPE) cells, and human astrocytoma cells (U373Mg). A custom HCMV DNA …