Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Human airway epithelium"”.
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3D Nanoscale Architecture and Physiology of the Human Airway Epithelium
… is observed in the differentiation of airway basal stem cells into multiciliated cells within the human respiratory epithelium – a tissue barrier crucial for protection against bacteria, viruses, and particulate matter. In this thesis, I present the first isotropic three-dimensional map …
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MUCIN-MEDIATED AND INTERFERON-DRIVEN DEFENSE MECHANISMS AGAINST INFLUENZA VIRUS INFECTION IN HUMAN AIRWAY EPITHELIUM
The human airway epithelium represents the primary site of infection for many respiratory viruses, including influenza A virus (IAV). To safeguard this tissue and maintain the functionality of the lung, humans possess a two-layer, extracellular, mucus barrier composed predominantly of individual …
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Mechanisms of virus infection of human airway epithelium cultured at an air-liquid interface (HAE-ALI)
ABSTRACT Polarized human airway epithelial (HAE) cultures are instrumental for studying respiratory tract diseases and gene delivery of airways. Primary epithelial cells isolated from tracheobronchial airways, grown in transwell at an air-liquid interface (ALI), undergo media-induced mucociliary …
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Exploring Ciliary Dynamics: Assessing Motility and Induced Velocity in Human Airway Cell Cultures
The human respiratory tract going from the nose to the terminal bronchioles is lined by a mucociliated epithelium. Here, cilia underpin an essential defence mechanism known as MCC. This process clears inhaled pathogens and contaminants from the airways and exhibits various degrees of complexity. …
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Elucidation of the roles of PTN and ISG15 in RSV cytopathogenesis: possible biomarkers of severe disease?
… Animal models only partially reflect RSV‐human host interactions and thus extrapolation of results from these models to human responses is of limited value. Study of autopsy specimens from infants who succumbed to RSV infection identified that the infection is restricted primarily to the …
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Investigating the impact of gold nanoparticles on pulmonary cells: From 2D to 3D culture systems
… uptake of rods and rod widths in primary human pulmonary artery endothelial cells. We also investigated gold nanorod secretion kinetics in a 10 h interval. At the end of 10 h, > 75% of rods were removed from the cells. The impact of gold nanoparticle aerosols on human airway epithelium …
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A Study of Human Coronavirus NL63: Characterization of Virus Replication, Targeting of Papain-Like Protease 2 by Antivirals and Probing Virus Mediated Innate Immune Antagonism
<p>Acute respiratory tract infections in humans are responsible for significant morbidity and mortality especially in children, elderly, and the immunocompromised. Virus infection is the primary cause of acute respiratory tract infections. Infection with coronaviruses can cause disease ranging from …