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Showing 1 to 20 of 76 for “"Human Umbilical Vein"”.
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The Decelluarized Human Umbilical Vein (HUV) as an Allogeneic Scaffold for Vocal Fold Tissue Engineering
The human umbilical vein (HUV) has great potential for use as a biological tissue engineering scaffold. Thus far, it has been used as an extracellular matrix (ECM) scaffold for cardiovascular tissue engineering applications due to its many structural and biomechanical advantages. Since the HUV is …
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The Decelluarized Human Umbilical Vein (HUV) as an Allogeneic Scaffold for Vocal Fold Tissue Engineering
The human umbilical vein (HUV) has great potential for use as a biological tissue engineering scaffold. Thus far, it has been used as an extracellular matrix (ECM) scaffold for cardiovascular tissue engineering applications due to its many structural and biomechanical advantages. Since the HUV is …
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The Influence of Human Umbilical Vein Endothelial Cells in the Formation of Glioblastoma Spheroids in Three-Dimensional Microwells
Glioblastoma multiforme (GBM) is the most malignant primary brain tumor with a high infiltrative capacity and increased vascularity. Despite current therapies overall patient survival rate is still poor. Therefore, alternative therapies have been considered for GBM treatment such as oncolytic …
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Evaluation of Human Umbilical Vein Endothelial Cells in Blood Vessel Mimics Through Changes in Gene Expression and Caspase Activity
<p>Blood vessel mimics (BVMs) are simple tissue engineered blood vessel constructs intended for preclinical testing of vascular devices. This thesis developed and implemented methods to characterize two of these components. The first aim of this thesis investigated the effect of cell culture …
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Interaction of Human umbilical vein endothelial cells and human hepatocytes celline on Gelatin-VEGF Microspheres and PHBV-HGF Microspheres in co-culture
This research focused on the fabrication of HGF encapsulated PHBV microspheres and VEGF encapsulated gelatin microspheres to ensure controlled release of growth factors as the microspheres degrade during cell culture. Blank microspheres and 2D cell cultures were used as controls. Characterization …
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Modulatory effect of EVOO polyphenols and their metabolites on inflammatory response in Adenocarcinoma Colon Cells (Caco-2) and Human Umbilical Vein EC (HUVEC)
… metabolites are the prevalent forms found in human plasma and urine where they reach relevant concentrations compatible with biological activity. In this context, the aim of the present research project was to evaluate the protective effect of the main phenolic compounds of EVOO, HT and Tyr, …
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A study on the resistances to oxygen transport in the microcirculation
… permeability of cultured bovine aortic and human umbilical vein endothelial cell monolayers was measured directly in vitro. The monolayers were cultured on silicone rubber membranes and placed in a carefully calibrated diffusion cell immersed in a 37$\sp\circ$C waterbath. The lower and upper …
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Modelling the movement of superparamagnetic beads engulfed in endothelial cells
… applications. Controlled placement of human umbilical vein endothelial cells (HUVECs) within a micro-porous, poly-caprolactone scaffold is facilitated with superparamagnetic beads introduced to the cells by phagocytosis. It is shown that the dominant motion of the affected cells is …
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Vasculogenic Scaffolds: How Cell-Cell and Cell-Matrix Interactions Regulate Vascular Differentiation and Morphogenesis
… vasculogenic potential were used in this study, human umbilical vein endothelial cells (HUVECs) and rat bone marrow stem cells (BMSCs). The vaculogenesis as well as levels of SMαA and vWF expression were determined using confocal microscopy. This analysis of the two scaffolds showed that cells …
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Regulation of specific connexins differentially alters gap junction permeability and endothelial cell function
… PAEC monolayers after 24 hours of incubation. Human umbilical vein endothelial cells (HUVEC) behaved in a similar manner. Inhibition of any one of the three connexins resulted in a marked increase in eNOS concentration.
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Endothelial cell response to bioactive peptides and stiffened extracellular matrices: an investigation into atherogenic pathways
… bioactive peptides was performed on cultures of Human Umbilical Vein Endothelial Cells (HUVECs) and two tripeptides (VPP and IPP) were found to liberate ~50% more NO. This finding drove a further investigation into whether endothelial cells grown on varying matrix stiffness would experience …
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Vitamin E and arachidonic acid metabolism in cultured human endothelial cells.
… approach to study the metabolism of nutrients in human cells was developed. The incorporation and depletion of 2R,4$\sp\prime$R,8$\sp\prime$R-$\alpha$-tocopherol (RRR-$\alpha$-T), a natural form of vitamin E, and its subsequent effect on the metabolism of arachidonic acid were conducted on human …
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Breast Cancer Cells Acquire a Stem-Like Phenotype by TGFß1/EGF Induced Epithelial-Mesenchymal Transition
… phenotype in BT-20 cells and promote adhesion on human umbilical vein endothelial cells (HUVECs) but cannot promote expression of EMT-related transcription factors in BT-20 cells. A combination of EGF and TGF-ß1 can promote expression of EMT-related transcription factors in BT-20 cells. These …
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Heterogeneity of injury in vasculitis: influence of anti neutrophil cytoplasm antibody IgG subclass and endothelial susceptibility.
… blockade reduced binding. GEC were compared with human umbilical vein endothelial cells. Surface VCAM-1 was reduced on GEC and GEC demonstrated reduced leukocyte capture. RNA array analysis demonstrated a reduction in the GEC gene responsible for post translational modification of VCAM-1 to a …
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Development of an In-Vitro Tissue Engineered Blood Vessel Mimic Using Human Large Vessel Cell Sources
… to create a bench-top blood vessel model using human cells that can be used to test and evaluate vascular disease treatments and intravascular devices. Previous BVM work has used fat derived human microvascular endothelial cells (EC) sodded on an ePTFE scaffold. To create a more physiologically …
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Regulation of Weibel-Palade Body Exocytosis by alpha-Synuclein in Endothelial Cells
… VWF release or translocation of P-selectin from Human Umbilical Vein Endothelial Cells (HUVECs) were inhibited by overexpression of a- and b-synuclein, but not g-synuclein. The overexpression of three point mutants (A30P, A53T and E46K) found in familial Parkinson’s disease inhibited WPB …
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Defining the human endothelial transcriptome
… these algorithms to the study of cultured human umbilical vein endothelial cells (HUVEC), we have found approximately 54% of all genes to be expressed at a detectable level in HUVEC under basal conditions. The set of highest expressed genes is enriched in nucleic acid binding proteins, …
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The Cytoskeletal Mechanisms of Cell-Cell Junction formation in Endothelial Cells
… of the underlying cytoskeleton in cultured human umbilical vein endothelial cells (HUVECs). We show that the initial interaction between cells is mediated by protruding lamellipodia. Upon their retraction, cells maintain contact through thin bridges formed by filopodia-like protrusions …
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MUTAGENIC EFFECTS OF CHROMIUM (IV) ON HUMAN ENDOTHELIAL AND LUNG EPITHELIAL CELLS
… (IV) monohydrate (Cr(IV)-DPO), on human umbilical vein endothelial cells (HUVEC) and human bronchial epithelial cells (BEAS-2B) were investigated through morphological, cell viability, gene expression, and cDNA sequencing assays. The cell morphology showed both HUVEC and BEAS-2B …
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