Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 148 for “"Human Tissue"”.
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Somatic Mutation in Cancer and Healthy Human Tissue
Somatic mutation is a natural process in healthy human tissues but has significant implications in a range of disorders and diseases with cancer being the most prominent example. In the last decade, genomics research generated big data resources that contributed tremendously to our understanding …
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Functional genomic analysis of cell cycle progression in human tissue culture cells
… gametogenesis over multicellular development to tissue formation and repair. Consequently, defects in cell cycle regulation provoke a variety of human cancers. A global view of genes and pathways governing the human cell cycle would advance many research areas and may also deliver novel cancer …
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Nonlinear Microscopy System and Protocol for Rapid Evaluation of Freshly Excised Human Tissue
… evaluation of biopsy and surgically excised tissue, playing a critical role in medicine. The clinical protocol for histology requires physical sectioning of tissue, either with intense chemical processing and paraffin embedding or freezing of tissue, limiting the rapid evaluation …
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A Patient-specific Irreversible Electroporation Treatment Planning Model Based on Human Tissue Properties
… region relies on the electrical response of human tissue during IRE. This work quantifies this response for the first time and implements human tissue properties in a patient-specific, 3D treatment planning model.
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Method of biological assay of Gastrin and its application to the study of human tissue
The relatively small number of cases in this series, aggravated by the need for further division into subgroups, makes interpretation difficult. The situation is made worse by a number of factors as yet unknown, e.g., the effect of anaesthesia and duration of operation on the gastrin content, the …
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The Electrical Properties of Human Tissue for the Diagnosis and Treatment of Melanoma Skin Cancer
… melanoma skin cancer. First, a background about human skin tissue is presented. Then, a detailed description of melanoma along with current diagnosis techniques and treatment options are presented. In the experimental methods, the electrical properties of several types of tissue were analyzed, …
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Hypoxia Acts As An Environmental Cue For The Human Tissue-Resident Memory T-Cell Differentiation Program
<p>Tissue-resident memory T-cells (T<sub>RM</sub>) provide frontline defense against viral diseases and can contribute to anti-tumor immunity; however, aside from the necessity of TGF-β, little is known regarding cues for T<sub>RM</sub> differentiation. Oxygen tension is an environmental cue that …
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Molecular Characterization of Human Tissue Samples by Raman Spectroscopy with Different Laser Modes and Excitation Wavelengths
… and pathological diagnosis of cancerous tissues. This technique has the merit of being highly sensitive to the biochemical alterations in tissue compositions. Nevertheless, the use of Raman spectroscopy in cancer detection has been impeded by high background intensity which can mask the …
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Beyond differential expression : methods and tools for mining the transcriptomic landscape of human tissue and disease
… phenotypes in the context of a myriad of tissues and diseases. We introduce scalable methods that associate expression patterns to phenotypes in order to assign phenotype labels to new expression samples and to select phenotypically meaningful gene signatures. By using a nonparametric …
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An analysis of consent with specific regard to stem cell therapy and research
… applications tantamount to research involving human subjects. This thesis therefore examines consent as regulatory instrument in context of stem cell related interventions and endeavours to introduce a sufficient consent model for such interventions. To this end, a clinical overview and …
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Pathological role of double-stranded DNA antibodies in multiple sclerosis.
… of anti-dsDNA antibodies was also performed in tissue taken from Biozzi (AH) mice (relapsing/remitting EAE model) and from a multiple sclerosis patient. Inflammatory deposits specifically at sites of perivascular cuffing were found to increase with increasing clinical sign severity. At the time …
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Static and Dynamic Stress/Strain Properties for Human and Porcine Eyes
… globe rupture pressures for healthy postmortem human and porcine (pig) eyes. Maximum rupture stress for the quasi-static tests was found to be 11.17MPa for human tissue and 12.08MPa for porcine tissue, whereas stress for the dynamic tests was found to be 30.18MPa for human tissue and 26.01MPa …
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Modeling, Optimization, and Control of Electromagnetic Oncological Hyperthermia
… of electromagnetic and thermal fields inside of human tissue are presented and validated. Various schemes for optimizing the effectiveness of hyperthermia treatments that exploit these numerical models are then presented. Lastly, the use of noninvasive temperature measurements, such as those …
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Double-Strand Break Repair Mechanisms in Human Embryonic Stem Cells
… of diseases as well as for providing normal human tissue to conduct scientific research. A major obstacle for their application is that genomic instability arises in stem cells after prolonged cell culture. The most detrimental form of DNA damage is the DNA double-strand break (DSB), which is …
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Low power CMOS IC, biosensor and wireless power transfer techniques for wireless sensor network application
… and meet the regulation on RF power exposed to human tissue (specific absorption ratio). Also, miniature sensor integration is another challenge since most of the commercial sensors have rigid form or have a bulky size. The objective of this thesis is to provide solutions to the aforementioned …
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Studies on the Molecular Biology of Naegleru Fowleri and Identification of N. Fowleri in the Environment
… of primary amebic meningoencephalitis. Healthy humans sporadically become infected with N. fowleri and develop fatal PAM after recreational or work exposure to freshwater; accordingly, there is a need for monitoring the presence of pathogenic amebeflagellates in public freshwater. The present …
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Development and validation of an in vitro human model of drug-induced vascular injury
… preclinically, driving a need to study this in human tissue. The aim of this thesis was to develop and characterise an in vitro human model that would allow the study of DIVI in human tissue during drug development. The first stage was to effectively reproduce DIVI in an animal model. To reduce …
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On Improving the Acquisition and Reconstruction Of Spatio-Temporal Magnetic Resonance Imaging
… flexibility in acquiring multiple forms of soft-tissue contrast. Recently, there has been a lot of interest in mapping the inherent magnetization properties of the underlying human tissue and in temporally resolving the acquired data. Broadly classified as spatio-temporal MRI, these methods yield …
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Modeling Alzheimer's Disease Using CRISPR/CAS9 Gene Editing and Induced Pluripotent Stem Cells Reveals Conserved Cellular Mechanisms
… the field for many years. Recently, advances in human induced pluripotent stem cell (iPSC) technology has enabled the study of uniquely human diseases, such as AD, in human tissue. However, the inability to precisely and efficiently genetically engineer human iPSCs has limited their use in …
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Accurate noninvasive monitoring of fetal tissue oxygenation level
… achieves <3% estimation error in a two-layer tissue phantom. Additionally, we perform in-vivo experiments to show that our system is able to detect reduced tissue oxygenation index (TOI) levels in a human arm, through a human tissue phantom, and can perform transabdominal fetal monitoring in …
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