Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Human Rhinovirus"”.
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The regulation of human airway epithelial expression of viperin by human rhinovirus
Human rhinovirus (HRV) is a major trigger of exacerbations of asthma and chronic obstructive pulmonary disease (COPD). Cigarette smoke is the primary cause of COPD, and 25% of asthmatics smoke. Asthmatic subjects who smoke have more severe disease. Smokers also have more frequent and severe viral …
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Modulation of TGFβ1-induced Fibroblast-to-Myofibroblast Transition in response to Prostaglandin E2 Production by Human Rhinovirus-Infected Airway Epithelial Cells
… marker of myofibroblasts. Given that human rhinovirus (HRV) infections are postulated to be involved in the pathogenesis of airway remodeling in asthma, we originally hypothesized that human airway epithelial cells promoted TGFβ1-induced FMT based on α-SMA expression by secreting …
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A Drug Discovery Study: Inhibitor Design for HRV 3C Protease Based on the Scaffold of (-)-Thysanone
… scaffold. The common cold, majorly caused by the Human Rhinovirus, still remains one of the major causes of work-loss in industrialised countries and currently only symptomatic treatment is available to treat these viral infections. Thus, even though this illness is not life threatening, a direct …
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Characterization of Human Airway Epithelial to Mesenchymal Transition upon Rhinovirus Infection
Human rhinovirus (HRV)-induced wheezing illnesses in early life are a major risk factor for subsequent asthma development, and may contribute to induction and progression of airway remodeling (AR) seen in the airways of asthmatic subjects. Thickening of the lamina reticularis is a component of AR …
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The Genetic, Molecular, And Cellular Bases Of Unidentified Primary Immunodeficiencies
… immune system is inseparable from every part of human biology. From cell intrinsic mechanisms of pathogen recognition to multi-cellular interactions over vast ranges of time and space, the immune system is both essential for protection from infection and central to the pathogenesis of many …
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Erythrocytes derived microvesicles : their characterisation and potential role as delivery vectors
… was observed. HeLa cells and those infected with Human Rhinovirus type 16 derived MV (HRV16iHMV) were used as parallel samples for all experiments. This is because virus infected cell derived EV have been extensively studied and it is understood that viral-MV uses the virus mechanism of entry to …
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Investigations into novel signalling pathways in the response to viral and bacterial infections
… via a physiological activator of TLR7, human rhinovirus 16 (HRV16). TRAM’s role in TLR7 is hypothesised to be dependent on its ability to membrane localise as overexpression of a TRAM myriostoylation mutant which is incapable of membrane localisation dose dependently inhibited TLR7 …
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Regulation of hnRNP A1 Cellular Localization by Protein Kinases and its Biological Impact
Human Rhinoviruses (HRVs) utilize Internal Ribosome Entry Sites (IRES) to drive viral protein synthesis. IRESs are specialized RNA elements present within the 5’ UTR of mRNAs that recruit ribosomes independently of the 5’ m7G cap structure. hnRNP A1 (heterogeneous nuclear ribonucleoprotein A1), a …
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A Molecular Epidemiological Study of Human Parainfluenza 4 in the Western Cape, South Africa
Background Human parainfluenza 4 (HPIV 4) is a recognised cause of acute respiratory infection (ARI). However, there is no published data on the epidemiology of this virus in South Africa. This thesis describes the molecular epidemiology of HPIV 4 over a 4-year period (2014-2017). Respiratory …