Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Human Pancreatic Islets"”.
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Therapeutic Gene Delivery to Human Pancreatic Islets for Treatment of Diabetes and the Effect of TFO on Liver Fibrosis Induced by Bile Duct Ligation
… diabetes. Earlier we have shown co‑expression of human vascular endothelial growth factor (hVEGF) and human interleukin‑1 receptor antagonist (hI‑1Ra) after transfection of plasmid DNA encoding these two genes. Due to poor transfection efficiency of plasmid DNA and the better known islet …
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NEW-ONSET HYPERGLYCEMIA AFTER SARS-COV-2 INFECTION
… direct and indirect effect of SARS-CoV-2 on human pancreatic islets could possibly occur. The serum of these patients showed toxicity on human pancreatic islets despite the lack of peripheral anti-islet autoimmunity, which could be reversed by the administration of anti-interleukin-1 beta …
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Mechanisms of defective insulin secretion in type 2 diabetes
Defective insulin secretion from the pancreatic B-cells is a central feature in type 2 diabetes (T2D). There is a strong hereditary component in type T2D, but the underlying pathophysiology remains largely unknown. This thesis uses a combination of gene network analysis and cell-physiological …
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Genetic and epigenetic influence on oxidative phosphorylation, islet function and type 2 diabetes in humans
… characterised by impaired insulin secretion from pancreatic β-cells and insulin resistance in peripheral tissues. Mitochondrial ATP production by oxidative phosphorylation (OXPHOS) is known to play a critical regulatory role in glucose stimulated insulin secretion (GSIS). The overall aim of this …
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Studies in beta cells and adipocytes in the context of obesity and T2D - focusing on PDE3B, OPN and SCFAs
… tissues and reduced insulin exocytosis from pancreatic β-cells. Obesity, which dramatically increases worldwide, is associated with insulin resistance and T2D. In this thesis, we elucidate the effects of hormones and nutrients on biological responses and regulatory mechanisms in pancreatic …
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A multi-ancestry genetic analysis of type 2 diabetes
… ~90% of diabetes cases, is characterised by pancreatic islet beta cell dysfunction and reduced insulin response in insulin-sensitive tissues, and is associated with a myriad of risk factors, including diet, obesity, activity measures, and genetics. Over the past century, there have been …
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The Path to an Orally Administered Protein Therapeutic for the Treatment of Diabetes Mellitus
… Various in vitro bioassays utilizing human embryonic kidney cells and human pancreatic islets were conducted and indicated B<sub>12</sub> has a minimally negative effect on GLP-1 biological activity. Finally we modified the structure of B<sub>12</sub> for future conjugation work. The …
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Mechanisms by which variants in the TCF7L2 gene increase the risk of developing Type 2 diabetes
… displayed higher TCF7L2 mRNA expression in islets of Langerhans, reduced insulin content and perturbed glucose stimulated insulin secretion. We have identified a large number of target genes (study I) and target networks (study II) of TCF7L2 that regulate β cell survival, proinsulin …
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The Human Pancreatic Islet Methylome and Its Role in Type 2 Diabetes
… to determine whether epigenetic dysregulation of pancreatic islets contributes to islet dysfunction in subjects with T2D. We also assessed the relationship between genetic variation and DNA methylation. We further examined the potential use of DNA methylation in blood DNA to predict future T2D. At …