Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"Human Monocytes"”.
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The Interaction of Neisseria Gonorrhoeae with Human Monocytes
The ability of human monocytes to phagocytize and kill nonpiliated opaque (T3) and transparent (T4) gonococci was investigated in a tumbling tube suspension assay. A serum-sensitive strain, F62, and a serum-resistant strain, FA19, were studied. Viable colony-forming units remaining after incubation …
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INTERDEPENDENT REGULATION OF METABOLISM AND INFLAMMATION IN HUMAN MONOCYTES
Sepsis is serious medical condition which kills millions of people worldwide each year. In the United States, severe sepsis has a mortality rate of 20-30%, with an annual cost of over $25 billion. Modern advances in supportive care have brought the mortality rate down to its current level, however …
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A Systems-Based Approach to Examine the Molecular Basis of Interactions between Human Monocytes and Human Micro-Vascular Endothelium
Human monocytes comprise three distinct subsets, defined by their relative expression of CD14 and CD16. These subsets appear to have different functional roles, which are only recently becoming delineated. Functional differences include the manner in which different monocytes interact with blood …
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The regulation of CXCR4 and CCR5 expression on human monocytes by Th1 and Th2 cytokines: Functional implications on cell migration and HIV infection.
… the regulation of CXCR4 and CCR5 expression by monocytes, and the functional implications of Th1 and Th2 cytokine induced alterations in chemokine receptor expression on chemotaxis and HIV infection, are poorly understood and constituted the major aim of this investigation. To understand the …
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Novel cytokines in innate immunity: IL-27 and IL-30 enhance responsiveness to gram-negative bacterial components in human myeloid cells
… IL-11, and IL-27 in CD4+ T cells. In primary monocytes, IL-27 promotes proinflammatory cytokine production and TLR4 expression in monocytes for a potent inflammatory response to bacterial endotoxin, LPS. Barring these studies, functions of IL-27 and IL-30 in human myeloid cells have not been …
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Experimental Models of Mycobacterial Replication and Killing in Macrophages
<p>This thesis investigates how human mononuclear phagocytes regulate the growth of mycobacteria. Previous studies carried out in our laboratory suggested that cell turnover [apoptosis and necrosis] within a granuloma may contribute to the control of mycobacterial infection. The experiments …
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Effects of Vitamin D on Expression of Toll-like Receptors of Monocytes from Patients with Behcet's Disease
… D3 through down-regulation of TLR expression in human monocytes. To understand the role of vitamin D affecting innate immunity in BD, we focused on the association between the serum vitamin D concentration and the TLR expression in BD. MATERIALS AND METHODS: Serum 25-hydroxyvitamin D levels were …
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The Influence of Biofilm on the Antifungal Activity of Amine Oxide
… is also found in the oral cavity of 65% of the human population—most of which is free from oral disease. A truth puzzling to investigators, the discovery of a self-produced, protective matrix present around colonies of communal bacteria and fungi (or biofilm) began to shed light on that …
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Regulation of Platelet-Activating Factor Acetylhydrolase by Oxidized Phospholipids and Proinflammatory Cytokines
… present. We have shown that PAFAH induction in monocytes is increased in response to oxidized phospholipids. The PAFAH 5' flanking region has at least 10 putative Stat elements, and IL-6 has been shown to be downstream from the prostaglandin receptor, EP2, which has been shown to bind oxidized …
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Απομόνωση και δομή προθυμοσίνης α αιγός και συμβολή στη διερεύνηση της βιολογικής δραστικότητας της προθυμοσίνης α
… only the C-terminal portion of the molecule. Human monocytes incubated in complete culture medium with prothymosin a produce increased quantities of thymosin a, (the N-terminal peptide fragment of prothymosin a) in the culture supernatants.
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Estudo da modulação da migração de células hospedeiras induzida por Leishmania e seu impacto na disseminação do parasito no hospedeiro
… spp. infect several vertebrate hosts, including humans. The diseases caused by this protozoan, leishmaniasis, can present different clinical manifestations, from localized skin lesions that heal spontaneously, to disseminated skin lesions, mucocutaneous form of the disease, and visceral …
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Tumor-Derived Retinoic Acid Regulates Intratumoral Monocyte Differentiation To Promote Immune Suppression
… to immunotherapy. Within solid tumors, why monocytes preferentially differentiate into immunosuppressive tumor associated macrophages (TAMs) but not immunostimulatory dendritic cells (DCs) remains unclear. Using multiple murine sarcoma models, we found that the TME induced tumor cells to …
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Modification of Low Density Lipoprotein and the Effects of Modified Low Density Lipoproteins on the Endocytic and Secretory Repertoire of the Macrophage
… oxidation of LDL showed that LDL isolated from human plasma anticoagulated with EDTA (EDTA-LDL) was 4-fold more resistant to oxidation by reagent H<sub>2</sub>O<sub>2</sub>, as measured by the thiobarbituric acid (TBA) assay, than LDL prepared from plasma anticoagulated with citrate (CDP-LDL). …
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The role of Poly (ADP-ribose) polymerase in the regulation of innate recognition of immunological receptors expressed on human macrophages.
… (MARCO). These receptors are expressed on most human monocytes and macrophages. CD14 recognizes and bind lipopolysaccharide (LPS), the main causative agents of sepsis and endotoxic shock. Signaling from CD14-LPS and TLR4/MD-2 complex activate the nuclear factor kappa B (NF-κB) family of …
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Nanoparticle effects on cell migration
… The first system that was examined in the human monocytes THP-1 cells. As a type of monocyte, THP-1 is known to migrate in response peptide formyl peptides. Another cell/chemoattractant pair that was examined was human dermal fibroblasts (HDF) and platelet-derived growth factor (PDGF). …
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Retinoid X Receptor activation reverses age-related deficiencies in myelin debris phagocytosis and CNS remyelination
… with ageing in both myelin-phagocytosing human monocytes and mouse macrophages. Disruption of RXR and PPAR using synthetic antagonists in young macrophages mimics ageing by reducing myelin debris uptake. Macrophage-specific RXRα knockout mice revealed that loss of RXR function in young …
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Regulation of Human Monocyte Function by Cross-Linking of Immunoglobulin E
… receptor on other innate immune cells, including monocytes, suggests that it may impact the function of these cells in allergic environments. Exacerbations of allergic disease have been associated with allergen exposure as well as viral and bacterial infection, but the mechanisms of these …
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The Eosinophil Granular Leukocyte; Source and Target of High Mobility Group Protein B1
… phosphorylation of p38 MAPK and NF-κB p65 in human monocytes and led proinflammatory mediator release. In addition, sHMGB1 exerted significant chemotactic properties toward neutrophils and eosinophils. Eosinophils also responded in autocrine fashion by degranulation. Moreover, sHMGB1 caused …
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Immunomodulatory activity of Lacticaseibacillus rhamnosus R0011: analysis of secretome-mediated impacts on innate immune outcomes in intestinal epithelial cells and antigen presenting cells
… rhamnosus R0011 secretome (LrS) in human IEC, indicating a potential for modulation of pro-inflammatory immune activity with minimal IEC impact in the absence of a pro-inflammatory challenge. This modulation may be mediated through induction of negative regulators of innate immunity …
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DESIGNING BIOMIMETIC NANOPARTICLES TO TACKLE INTRACELLULAR PATHOGENS
… (NGs), derived from the plasma membranes of human monocytes (THP-1 cells and primary CD14+ monocytes). These NGs were designed to retain key membrane features while excluding nuclear and cytoplasmic content, with the goal of targeting intracellular Mab more effectively. We adopted a stepwise …
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