Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"Human Microbiome"”.
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Mining the human microbiome for clinical insight
The human microbiome is essential for health and has been implicated in many diseases. DNA sequencing has enabled the detailed characterization of these human-associated microbial communities, leading to a rapid expansion in studies investigating the human microbiome. In this thesis, I describe …
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Towards in vivo editing of the human microbiome
The human microbiota consists of 100 trillion microbial cells that naturally inhabit the body and harbors a rich reservoir of genetic elements collectively called the microbiome. Efforts based on metagenomic sequencing of microbiomes associated with healthy and diseased individuals have revealed …
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A Transformer-Based Foundation Model for Human Microbiome Analysis
The human microbiome plays a crucial role in maintaining our health. Alterations in the microbiome have been linked to various chronic conditions like autoimmune disorders, metabolic diseases, and cancer. While various tools have been developed to study the microbiome, each tool tends to be …
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An oxygen-controlled in vitro model of the gastrointestinal human-microbiome interface
… plays a vital role in the functioning of the human body, processing food into useable energy, controlling homeostasis, and serving as the front line of the immune system. The intestines are aided in their many functions by the gut microbiome, a collection of 100 trillion anaerobic bacteria …
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Statistical Modeling for High-dimensional Compositional data with Applications to the Human Microbiome
… </p> <p>Chapter 1 introduces the compositional microbiome data, and then briefly review different statistical tests and model to be used in our framework, including distance correlation, LASSO, Ridge regression, elastic net, cumulative logit and adjacent-category logit model. </p> <p>Chapter 2 …
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Phylogenetic and functional characterization of human microbiome intra-species diversity and tracking of early-life transmission
The human gut is colonized by a vast bacterial community that is currently rather well characterized at the species level. Yet, each of these species harbor a tremendous amount of individual genetic variations. Our understanding of the human gut microbiome, its dynamics, composition and impact on …
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Large-scale metagenomic analysis of food-associated microbial communities and their links with the human microbiome
Complex microbiomes are part of the food we eat: they are naturally present on the raw material, they merge along the food system, or they can be intentionally inoculated. Whether their presence is desired, such as in case of fermentation or probiotic supplementation, or undesired, in case of …
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Exploring the impact of gastrointestinal parasitic helminths on the human microbiome using advanced biomolecular and bioinformatics technologies
Our understanding of the biology of human gastrointestinal (GI) parasitic helminths is greater than ever before. However, so far, the research has focused on gene expression profiling, immune- and protein-protein interactions in host-parasite systems. The importance of parasite microbiota …
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Enhancing Microbiome Host Disease Prediction with Variational Autoencoders
<p>Advancements in genetic sequencing methods for microbiomes in recent decades have permitted the collection of taxonomic and functional profiles of microbial communities, accelerating the discovery of the functional aspects of the microbiome and generating an increased interest among clinicians …
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Statistical Inference For High Dimensional Models In Genomics And Microbiome
Human microbiome consists of all living microorganisms that are in and on human body. Largescale microbiome studies such as the NIH Human Microbiome Project (HMP), have shown that this complex ecosystem has large impact on human health through multiple ways. The analysis of these datasets leads to …
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Statistical Methods For Assessing Structural Change In Human & Microbial Genomes
… <p>In this dissertation, we also studied the human microbiome, which has been associated with complex diseases, for example, cardiovascular disease, diabetes, obesity, and specific cancers. To our knowledge, the existing literature has rarely discussed how to process raw human microbiome data …
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MODE OF BIRTH AND VAGINAL MICROBIOTA IN REPRODUCTIVE-AGE WOMEN
… in the initial seeding, or colonization, of the human microbiome, and the transfer of microbiota from mother to baby during delivery is associated with long-term health. We recruited 88 adult women to a cross-sectional study to evaluate the relationship between their vaginal microbiota and the …
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Computational Tools and Resources for Pan-Cancer Analyses of Host-Microbe Interactions
<p>The human microbiome is a dynamic, integrated ecosystem that interacts with the host to influence cancer development and progression, as well as affect response to anti-cancer therapies, suggesting opportunities for diagnostic and therapeutic approaches. Many microbe-microbe and host-microbe …
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Benign, potentially malignant & malignant oral lesions; an analysis of oral and gut microbiota
Introduction: The human microbiome is widely known to be associated with health and disease. The oral microbiome has been linked with oral diseases and infections, though not many studies have explored the relation between oral and gut microbiome with oral cancer based on their histology. This …
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A phylogenetic framework for large-scale analysis of microbial communities
The human microbiome represents the community of archaea, bacteria, micro-eukaryotes, and viruses present in and on the human body. Metagenomics is the most recent and advanced tool that allows the study of the microbiome at high resolution by sequencing the whole genetic content of a biological …
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Molecular Analysis of Phenotypic Diversity in Human Fungal Pathogens
Fungal pathogens are a leading cause of human mortality, in part due to their ability to thwart therapeutic regimens by rapidly evolving resistance to antifungal drugs, and their ability to readily adapt to the hostile conditions experienced in a mammalian host. Candida species can colonize various …
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Shotgun metagenomics exploration of fermented food microbiomes
… of information can be extracted from these food microbiomes. This thesis explores the utility of this technology on a wide variety of these foods. In chapter 1, we review the combination of omic technologies to understand the role of the fermenting microbes on various attributes of the food …
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Aromatic Amino Acid Metabolome In The Human Gut Microbiota
… for convergent biosynthetic pathways. Several human signaling molecules are simple structures derived from aromatic amino acids (phenylalanine, tryptophan, and tyrosine). In this thesis, I employed targeted and untargeted mass spectrometry-based approaches to identify novel bacterial …
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The mucosal microbiome of inflammatory bowel diseases
The human microbiome is the diverse community of micro-organisms that live with humans. The gut microbiome contains the densest collection of microbial cells in the body and has been described as functioning as an organ. Alterations in these microbial communities are associated with disease. This …
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Novel Sequence-Based Method for Identifying Transcription Factor Binding Sites in Prokaryotic Genomes
… sequencing technology and the human microbiome project underway, current sequencing capacity is significantly greater than the speed at which organisms of interest can be experimentally probed. We have developed a method that will primarily use available sequence data in order …
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