Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"Human Lung cancer"”.
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Investigation of the Biological Effects of Rosemary (Rosmarinus Officinalis L.) Extract in Human Lung Cancer Cells
Cancer cells display enhanced growth rates and a resistance to apoptosis. Lung cancer accounts for the most cancer related deaths and non-small cell lung cancer (NSCLC) represents an aggressive form of lung cancer, accounting for almost 80% of all lung cancer cases. The phytochemical rosemary …
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Expression of Prxiredoxin I, III and Thioredoxin in human lung cancer and the normal lung tissues
… may co-exist in many solid tumors, such as lung cancer. The relatively new family of novel antioxidant proteins, peroxiredoxins (Prxs), have been implicated in regulating many cellular processes including cell proliferations, differentiation, and apoptosis. They are also reported to function …
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Nrf2-Dependent Overexpression of Sulfiredoxin and Peroxiredoxin III in Human Lung Cancer, Especially Squamous Cell Carcinoma
… in A549 cells 12 B. Oxidation of Prx III in mink lung epithelial cells 12 C. Srx dependent regulation of Prx III oxidation in A549 cells 15 D. Srx is translocated into the mitochondria under oxidative stress 15 E. Overexpression of Prx I and III isoforms in human lung cancer 19 F. Nrf2 dependent …
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Role of Substrate Stiffness on Migratory Properties and Epithelial to Mesenchymal Transition in Human Lung Cancer Cells
<p>Cancer affects a large percentage of the population in the United States, and innumerable research efforts are dedicated to studying the attributes of cancer to develop effective therapies. The mortality rate increases significant when the primary tumor begins to metastasize to different parts …
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Development of a Human Lung Cancer Cytochrome C-GFP Reporter Cell Line to Study Anti-cancer Drug Responses in Apoptosis Pathways
… radiotherapy are the most popular methods for cancer treatments after surgery, but lack of specificity and are thus toxic to the healthy human cells. Studies have shown that targeted therapies have been linked to activation of apoptosis signal pathways (cascade of caspases) in cancer cells …
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Analysis of the effects of BrdU on DLKP human lung cancer cells by two-dimensional difference gel electrophoresis and mass spectrometry
… reported that treatment with lOyM BrdU in the human lung carcinoma cell line (DLKP) resulted in increased expression of the cytoskeletal proteins Keratin 8 and 18 and the cell adhesion proteins a2 and b1 integrin. This study investigated protein expression changes in differentiating DLKP cells …
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Analysis of a novel antimicrobial peptide QUB-1746 from the skin secretion of the frog, Kassina senegalensis
… horse red blood cells. MTT assay tested two human lung cancer cell lines, H23 and H157, for effects. The results of antimicrobial experiments showed that QUB-1746 was active only against the Gram-positive bacterium, S.aureus with an MIC value of 32 μM. The results of MTT assays showed that …
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Identification and functional study of a novel bioactive peptide QUB-1761 from the venom of the Brazilian yellow scorpion, Tityus serrulatus
… (MIC=128 µM for Candida albicans). In MTT anticancer cell proliferation and trypan blue exclusion assays, QUB-1761 beyond the concentration of 40 µM can completely kill the human lung cancer cells (NCI-H838). In terms of the haemolytic assays, QUB-1761 showed about 30% haemolysis activity at 64 …
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Identification and activity assessment of a bioactive peptide QUB-1368 from the skin secretion of the American bullfrog (Rana catesbeiana)
… µM, QUB-1368 has no inhibitory effect on the human lung cancer cell line (H838). In the haemolysis assay, QUB-1368 showed haemolytic activity at a concentration of 256 µM, when QUB-1368 showed antibacterial activity, the concentration did not reach to produce hemolysis. In summary, QUB-1368 …
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Assessing bioactivity of peptide QUB3203 from the skin secretion of the Edible frog Pelophylax kl. esculentus
… assays including antimicrobial assays, anticancer assays and haemolytic assays.<br/><br/>In this research, QUB3203 shown significant effective antimicrobial bioactivity against the Gram-positive bacterium, S. aureus, the Gram-negative bacterium, E. coli and the yeast, C. albicans, at minimum …
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Microrna-200 Regulates Ecm-Dependent Β1-Integrin/Fak Signaling and Cancer Cell Invasion
… cell-intrinsic changes are insufficient to drive cancer cell invasion, leading us to focus on specific cell-matrix interactions required to activate tumor cell invasion and metastases. We have shown through 3D studies that the Integrin β1-collagen I contact is critical in mediating the invasive …
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A novel bioactive peptide QUB-2022 from the skin secretion of Phyllomedusa bicolor
… series assays, such as antimicrobial assay, anticancer assay and haemolysis assay were performed. The results showed that peptide QUB-2022 has a significant effect against Gram-positive bacteria but a little effect against Gram-negative bacteria. It exhibited lower potency against fungus. In …
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Assessment of antimicrobial and antiproliferative activities of a bioactive peptide from the skin secretion of white-lined leaf frog
… possessed an antiproliferative activity against human lung cancer cell line H838 at 10 µM. However, significant haemolysis activity was observed above peptide concentrations of 16 µM. Taken together, this dermaseptin peptide with potent bacterial effects on both Gram-positive and Gram-negative …
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Novel Lipid Polymer Design for Nucleic Acids Delivery
… sgRNA- Cas9 complexes to triple-negative breast cancer (TNBC) cells (MDA-MB-231) and siRNA against Respiratory Syncytial Virus (RSV) viral proteins in human lung cancer A549 cells. We hypothesize that incorporating hydrophobically modified polyethyleneimines (PEIs) into optimized LNP formulations …
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Molecular pathways controlling DNA damage response
P53 is inactivated in around 50 % of human neoplasms and more than 26,000 somatic mutations of the p53 have reported in human cancers. P53 network is activated after cells are exposed to the DNA damage and depending on diverse conditions and type of DNA damage, p53 upregulation could lead to …
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Role of Monocarboxylate transporter in lung development and lung cancer
Some studies suggest that lung tumour cell ontogeny is determined by consequences of gene expression that recapitulate important events in embryonic lung development. Hypoxia plays a crucial role either in physiological or pathological conditions such in tumour growth, and in embryonic and fetal …
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Surface Modification of Spherical Particles with Bioactive Glycopolymers
… only in the cytoplasm but also in the nucleus of human lung cancer cells. This cell line expresses a galactose-binding protein which indicates that carbohydrate-lectin interactions are responsible for the uptake of the functionalized particles. In general, these studies show the capability of …
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Nanoparticle based chemotherapy for pulmonary drug delivery in treating lung cancer
In the UK, there are approximately 46,403 new lung cancer cases and 35,600 deaths in 2016 due to lung cancer, with a survival rate estimated to be less than 10 years in 95% of cases. Cisplatin treatment is being considered in all stage non-small cell lung cancer patients with overall benefits of …
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Tumor cell-intrinsic signals promoting tolerance and adaptation to oncogenic kinase inhibition
… longer survival and superior quality of life for cancer patients with particular malignancies compared to the preceding standard of care. However, many patients still fail to show a clinically meaningful response to kinase inhibitors prescribed on the basis of tumor genotype, and nearly all …
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Characterisation of the effect of electroporation and electrochemotherapy on cancer cells and immune cells in the tumour microenvironment
Lung cancer is the leading cause of cancer-related death worldwide, with the lung cancer incidence rate expected to rise further. Despite recently developed novel therapy options, 5-year survival rates for lung cancer patients remains below 20% generally and below 5% for late-stage diagnosis, thus …
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