Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 112 for “"Human Liver"”.
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Modelling human liver bud development in vitro
Understanding human development, specifically the initiation of human organogenesis, remains a major challenge not only in the field of developmental biology but also to understanding regenerative processes and developmental disorders. However, studying the initial stages of human organ development …
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MAdCAM-1 expression and function in human liver
… Recent studies have reported its expression in liver diseases such as primary sclerosing cholangitis (PSC) and autoimmune hepatitis (AIH) that complicate IBD, therefore understanding the factors that drive hepatic expression of MAdCAM-1 might elucidate the pathogenesis of these diseases. In …
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Purification, identification and characterization of "atypical" human liver alcohol dehydrogenase isoenzymes
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Human Liver Organoids as models for investigating drug-induced liver injury
The liver is the primary organ involved in drug detoxification, hence being highly exposed to the risk of drug induced liver injury (DILI). DILI is the main cause for acute liver failure in western countries and post-marketing withdrawal of drugs. This is highly due to the poor identification of …
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Probabilistic Analysis of the Material and Shape Properties for Human Liver
Realistic assessments of liver injury risk for the entire occupant population require incorporating inter-subject variations into numerical human models. The main objective of this study was to quantify the variations in shape and material properties of the human liver. Statistical shape analysis …
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Differential gene expression analysis of metolachlor treated human liver cells by microarray
1 PDF file (viii, 159 pages)
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Molecular responses of iron regulatory proteins to iron overload in human liver
… key iron-related molecules were investigated in liver specimens from patients with HFE-related HH. Protein levels of iron regulatory protein 1 (IRP1), a known regulator of iron uptake and storage in cells, were found to be consistently down-regulated in the liver of patients with HFE-related HH …
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The role of relaxin in the regulation of human liver and kidney fibrosis
Liver fibrosis has a range of aetiologies and is a global cause of mortality. A<br/>critical effect of liver fibrosis which also increases mortality is portal<br/>hypertension. The hepatic stellate cell is accepted as a major progenitor of liver<br/>myofibroblasts, which have been shown to be a …
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Regulation of Senescence Phenotypes by TIS21 gene in Huh7 Human Liver Cancer Cells
… 유전자는 mouse에서는 TIS21(TPA inducible sequences 21), human에서는 BTG2(B-cell translocation gene-2), rat에서는 PC3(pheocromocytoma clone-3)로 존재하는 동등 유전자이다. TIS21는 세포내의 전사 보조 인자, 신경세포 분화인자 및 성장억제인자로서 thymocyte 의 stage-specific expansion 을 매개하는 중요인자이고 조혈모세포 증식억제인자로 보고된 바 있다. 이 외에도TIS21은 암 억제, 세포사멸(Apoptosis), …
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Recruitment and positioning of regulatory T cells and Th17/Tc17 in inflamed human liver
The liver is a unique tolerogenic organ with dual blood supply. Both regulatory lymphocytes and effector lymphocytes are present in the normal and inflamed liver along with innate immune cells. The balance between these two subsets of lymphocyte is crucial in maintaining immune homeostasis by …
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EFFECTS OF THE LIVER MICROENVIRONMENT ON HUMAN LIVER SINUSOIDAL ENDOTHELIAL CELLS DURING IN VITRO CULTURE
Liver Sinusoidal Endothelial Cells (LSECs) are specialized endothelial cells that play an important role in the metabolic and xenobiotic clearance functions of the liver. LSECs are distinguished by their hallmark characteristics of lacking a distinct basement membrane and containing open pores …
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Subcellular Fractionation Methods for the Quantification of Endogenous Protein in Human Liver Using Targeted Proteomics
… for pharmacokinetics. Recently, interest into human endogenous protein quantification using targeted quantitative proteomics has increased. These quantification measurements are useful in many aspects of drug discovery and development, including protein biomarker monitoring, the development of …
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Mapping Human Liver Development using Single-Cell Transcriptomics to Reveal Pathways Directing Stem Cell Fates
The liver is an organ with a diversity of essential functions including xenobiotic removal, bile acid production, storage of iron and vitamins, and metabolism of glucose and fatty acids. Hepatocytes, comprising the liver parenchyma, fulfil these functions and form an extensive network with …
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Characterization of a human liver esterase distinct from butyrylcholinesterase catalyzing the hydorlysis of cocaine to ecgonine methyl ester
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Design Synthesis and Evaluation Of Diterpenones As Potent Chemopreventive Agents For Aflatoxin B1 Induced Carcinogenesis In Human Liver Cells
… AGENTS FOR AFB1 INDUCED CARCINOGENISIS IN HUMAN LIVER CELLS By Miguel A. Zuniga, Ph.D. A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University. Major Director: Qibing Zhou, Ph.D Assistant Professor …
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Propoxyphene, Norpropoxyphene, and Proadifen (SKF-525A) Are Mechanism Based Inhibitors of CYP3A4, CYP3A5, and CYP3A in Human Liver Microsomes
… studies with CYP3A4(+b5), CYP3A5(+b5) and pooled human liver microsomes. Time-dependent and concentration-dependent loss of activity of CYP3A was measured by formation of testosterone product. Propoxyphene and norpropoxyphene exhibited the greatest inhibition with CYP3A in human liver microsomes, …
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