Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"Human Leukocyte Antigen (HLA)"”.
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Human Leukocyte Antigen (HLA) Associations and Gulf War Illness (GWI)
… of the immune system. Many studies show Human Leukocyte Antigen (HLA) associations with autoimmune, infectious, and inflammatory diseases. Researchers have hypothesized that the multi-symptom nature of GWI may share an autoimmune component. In order to test for a potential immunological …
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Gyper: A graph-based HLA genotyper using aligned DNA sequences
… þúsunda lífvera. Í manninum er hann kallaður human leukocyte antigen (HLA) og er staðsettur á styttri armi litnings 6. Vitneskja um hvaða genasamsætu einstaklingur hefur er mikilvægt fyrir svið læknisfræðinnar. Ýmsar leiðir eru til staðar sem geta til um tegund HLA genasamsætu einstaklings með …
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Cross-Presentation Is A Source of Tumor Antigens For Multiple Myeloma Immunotherapy
… and adaptive arms of the immune system where antigen presenting cells (APCs) prime cytotoxic T cell responses. We have recently identified cross-presentation as a mechanism by which solid tumors present exogenous antigens. We therefore hypothesized that multiple myeloma would be capable of …
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An Investigation into the Potential of Cell Therapies for Acute Myeloid Leukemia (AML) Treatment
… including treatment-related toxicities and human-leukocyte antigen (HLA) matching. Natural killer (NK) cells and gamma delta (γδ) T cells offer alternative effector cell options for cell therapies that do not require HLA-matching and have shown low toxicity in previous studies. In this …
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Conserved Non-Pocket Interactions Drive The Diversity of Peptide Presentation By Mhc Class I Molecules
… through recognition of peptides presented on human leukocyte antigen (HLA) molecules. A thorough understanding of peptide-HLA interactions is needed for improvement of CTL-based immunotherapies. We observed that aspartic acid (D) and glutamic acid (E) at peptide position 4 are highly prevalent …
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Killer Cell Immunoglobulin-Like Receptors Delineate Distinct Phenotypes and Functions in Human γδ T Cells
Human circulating γδ T cells are broadly classified into three subsets: Vδ1, Vδ2, and Vδ1/2neg populations, with the Vδ2 subset being the most abundant. In this research, I focus on the contribution and interplay of Natural Killer (NK) receptors to the γδ T cell phenotype and function, with …
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Immune system involvement in metal hip implant failure
… Ultima implant. This study investigated; The Human leukocyte antigen (HLA) allelic variation and implant failure association. Determined the composition and frequency of immune cells and inflammatory markers in Norfolk cohort. And tested the metal particle impact on immune cells. These …
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The role of soluble factors affecting the major histocompatibility complex class I molecules In an IN VITRO model of the fetomaternal interface
Human main histocompatibility complex is encoded in the short arm of chromosome 6 and can be divided into three main regions based on the proteins that it encodes. We have class I, class III and class II. Class I encodes for proteins that are expressed on the cell surface of almost all somatic …
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The Role of Immunological Receptors CD74 and CD44 in Association with the Macrophage Migration Inhibitory Factor (MIF) on Human Breast Cancer Derived Cells
… In normal cells CD74 functions as a chaperone of human leukocyte antigen (HLA)-DR biosynthesis and is expressed in antigen presenting cells in the absence of tumours. Notably, CD44 is also a transmembrane receptor and member of a family of cell adhesion molecules responsible for adhesion between …
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The immunopathogenic mechanism of severe cutaneous adverse reactions to first line anti-tuberculosis drugs
… We hypothesize that polymorphisms in Human Leukocyte Antigen (HLA), Endoplasmic Reticulum Aminopeptidase (ERAP) and Killer Immunoglobulin Receptor (KIR) genes along with HIV-related immune dysregulation during drug exposure might confer susceptibility. In this thesis, we aimed to …
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Computational Evaluation and Structure-based Design for Potentiation of Nicotine Vaccines
… necessary before they can achieve approval for human use. In this report, three separate approaches towards NV potentiation are explored. The first approach applied physiologically-based pharmacokinetic (PBPK) modeling to better assess NV potential. Rat and human physiological and …
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Characterizing The Source of Neutrophil Elastase and Proteinase 3 Cross-Presentation In B-Cell Acute Lymphoblastic Leukemia
<p>Discovery of tumor-associated antigens is an important step in designing effective antigen-targeting immunotherapies. PR1 is a nonameric human leukocyte antigen (HLA)-A2 restricted leukemia-associated antigen derived from serine proteases neutrophil elastase (NE) and proteinase 3 (P3). NE and P3 …
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Evaluating the predictive performance of cytotoxic T lymphocyte epitope prediction tools using Elispot assay data
… been previously devised to predict potential human leukocyte antigen (HLA) binding peptides from protein sequences. These tools are complements of Enzyme-linked immunosorbent spot (ELISpot) assays - a very commonly applied immunological technique that is used both to identify regions of …
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Investigating the role of HLA class I derived peptide in alloreactivity.
The peptide complexed with human leukocyte antigen (HLA) can be said to have a significant role in the generation of alloresponses, both in terms of cellular and humoral alloresponses. Previous researchers have identified minor histocompatibility antigen (mHAG) derived peptides such as HA-1, and …
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Early life phenotypes of type 1 diabetes genetic risk
… the contribution of the T1D susceptibility human leukocyte antigen (HLA) alleles, which explain half of disease heritability, to perinatal growth but findings are inconsistent. In the Cambridge Baby Growth Study (CBGS), a birth cohort which follows children over the first 2 years of life, I …
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Adult Human Microglia: Phenotypic Diversity and Functional Complexity
… regulators of brain physiology. The adult human brain is prone to immune dysregulation in neurodegeneration and normal ageing. Understanding the roles and mechanisms of microglia in the adult human brain will aid the understanding of normal and degenerative brain processes. Despite …
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Molecular basis of TAPBPR-mediated peptide editing on MHC class I molecules
… class I molecules, by screening a wide panel of human leukocyte antigen (HLA) class I allotypes for their relative propensities to undergo peptide editing by TAPBPR. TAPBPR displayed a clear functional preference for HLA-A molecules, particularly for members of the A2 and A24 supertypes, over …
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Characterising the immunopeptidome in hepatitis B
… major histocompatibility class I (MHC-class I, human leukocyte antigen (HLA) class I in humans) molecules on the cell surface is crucial to mount antiviral immune cell mediated responses. Immunogenic peptides are generated and selected via the HLA class I antigen presentation pathway (APP). …
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Investigation of novel therapeutic strategies in B cell and antibody mediated disease
… cells activate alloreactive T cells and secrete human leukocyte antigen (HLA) and non-HLA antibodies that negatively affect graft function and survival, but may also play a protective role by regulating alloimmune responses promoting transplant tolerance. B-Lymphocyte Stimulator (BLyS) is a …
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Separation and Further Characterization of Hematopoietic Cell Populations Based on Phenotypic and Biophysical Properties
… (GvHD). In case of recipient-donor tissue antigen disparity, such as human leukocyte antigen (HLA)-mismatch or ABO-incompatibility, depletion of allo-reactive or incompatible blood constituents by HSCT graft processing may be required. The aim of this work was to investigate the development …
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