Global ETD Search
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Showing 1 to 8 of 8 for “"Human Endogenous Retroviruses (HERVs)"”.
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Characterization of The Role(S) of Env Protein of Human Endogenous Retrovirus-K In Multiple Human Cancers
<p>Human endogenous retroviruses (HERVs) are remnants from ancient retroviral infections, and most of them are inactive in normal tissues. One family of HERV, HERV-K, is found to be associated with multiple human cancers including breast cancer, pancreatic cancer and melanoma, but the causal …
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The detection and role of human endogenous retroviruses in multiple sclerosis and other neurological diseases
Human endogenous retroviruses (HERVs) are estimated to form approximately 5% of the human genome. While the majority of sequences are defective, containing premature stop mutations and frameshift mutations, a number encode fully functional proteins. HERVs have been proposed as aetiological agents …
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Investigation of Endogenous Retroviruses in the Pathogenesis of Sporadic Amyotrophic Lateral Sclerosis (ALS) by
Human Endogenous Retroviruses (HERVs) are remnants of ancient retroviral infections that have become incorporated into the human genome over the course of our evolution as a species. These fossil viruses have been co-opted by our genome as regulators of cellular gene expression amongst various …
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Characterization of Human Endogenous Retrovirus sequences identifed in the human genome using the RetroTector software
Human Endogenous Retroviruses (HERVs) represent the inheritance of ancient germ-line cell infections by exogenous retroviruses and the subsequent transmission of the proviral integrated elements to the descendants. Actually, no replication-competent HERV sequence is recognizable in the human …
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Endogenous retroviral proteins as potential drug targets for merlin-deficient tumours
… is an urgent need for new therapeutic options. Human endogenous retroviruses (HERVs) are retroviruses that have been incorporated into the human genome during evolution, now comprising 5% of it. The majority of HERVs are defective except for a few groups, including type K (HERV-K) which kept …
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Avian leukosis virus as a risk factor for ovarian adenocarcinoma in layer hens
… and epidemiological characteristics. Recently, human endogenous retroviruses (HERVs) have been shown to be associated with ovarian cancer in women. Hens also have endogenous retroviruses, notably Avian Leukosis Virus E (ALV-E). The link between ALV-E and OAC in hens has not been adequately …
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Characterization of the human endogenous retrovirus HERV-‐K(HML-‐6) and HERV-‐K(HML-‐10) sequences and analysis of their expression
It has been estimated that 8% of human genome is composed of sequences originating from exogenous retroviruses that infected the germ line cells over millions of years and are termed human endogenous retroviruses (HERVs). After germ line infection, the retroviral DNA was integrated into the genome …
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Contributions of viral and cellular gene products to the pathogenesis and prognosis of aggressive lymphomas
High grade aggressive lymphomas have high mortality. By their nature, more than 40% of patients die from these diseases even with the improved treatment strategies currently available for oncology patients. The characteristic feature is that they are functionally heterogeneous and therefore have …