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Showing 1 to 3 of 3 for “"Human DNA replication"”.
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Functional and structural investigations of human replisomes assembled from purified proteins
DNA replication is a fundamental biological process for the transmission of genetic information from one generation of cells to the next in each cell division. Errors or abnormalities during replication can lead to mutations and genome instability, which is a hallmark of cancer. The complex and …
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The Interaction of the Human Adenovirus E1A Protein with the Human DREF Transcription Factor
The human adenovirus (HAdV) E1A protein is the first protein produced post-HAdV infection, and serves two main functions. The first is to modulate host and viral transcription. The second is to induce host cell cycle progression to S phase, to promote an optimal environment for viral replication. …
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The genome-wide analysis of the specification and activation of human chromosomal DNA replication origin sites
Background: Human DNA replication is a critical cellular process that initiates at tens of thousands of DNA replication origins. Next-generation sequencing (NGS) enabled the elucidation of some characteristics that define human replication origins. Initiation-site sequencing (iniSeq) utilises the …