Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Human Cortical Organoids"”.
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Traumatic Injury-Induced Cell Responses in Human Cortical Organoids
… Although animal models and reductionist human cell culture systems provided important mechanistic insights, there is no available therapy to prevent pathological progression, which warrants the need for more sophisticated human models. Here, I developed a 3D human stem cell-derived …
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DISSECTING THE MOLECULAR MECHANISMS RELATED TO THE ONSET OF NEUROLOGICAL COMPLICATIONS IN THREE CELLULAR MODELS OF SARS-COV 2 INFECTION: IPSC-DERIVED MOTO R NEURONS, IPSC-DERIVED DOPAMINERGIC NEURONS, IPSC DERIVED-HUMAN CORTICAL ORGANOIDS.
… of success [29–37]. Further, considering that human brain tissue is difficult to access, particularly from patients with a contagious pathogen due to safety concerns [38], 2D and 3D in vitro models can provide a viable and safe alternative and represent a suitable model system to test the …
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Elucidating Astrocytic Diversity in Human Cerebral Organoids
… in part due to the difficulty of modelling the human brain and astrocyte specification in a dish and the significant differences found between mouse and human astrocytes. To overcome these difficulties, cortical organoid slice cultures derived from human embryonic stem cells (hESCs) were …