Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Human Cell Atlas"”.
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Towards a complete human cell atlas: a single-nucleus RNA sequencing study of the paediatric and adult human brain
Postnatal human brain maturation from birth to early adulthood represents a period of susceptibility for neuropsychiatric risk. While temporal gene expression dynamics over this period have been studied extensively, there are no studies exploring the paediatric brain at single cell resolution. To …
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Understanding Development of Human Immunity One Cell at a Time
The emergence of single-cell and spatial multi-omic technologies has revolutionized our understanding of the immune cells. The international Human Cell Atlas consortium has spearheaded and coordinated a global effort to construct atlases of human tissues across multiple developmental stages. This …
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Interpreting Raman spectra using machine learning: towards a non-invasive method of characterizing single cells
… measure the biomolecular changes in single cells in a label-free manner. However, the extent to which Raman spectra can effectively infer biologically-relevant information is not well understood. In this thesis, we use machine learning methods to explore the ability of Raman microscopy data …
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Transcriptional Characterisation of Human Musculoskeletal Development in vivo and in vitro
… For example, it was absent from the original Human Cell Atlas (HCA) white paper; a global project which aims to compile a reference map of all human cell types to better understand health and disease. Applying the technologies used by the HCA to study the development of the musculoskeletal …
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Studying lung development in vitro: expanding the genetic toolbox and analysis of SOX2 and SOX9 function
Respiratory disease is a growing threat to human health worldwide. Induced pluripotent stem cell (iPSC) based stem cell therapy is promising for end-stage respiratory disease patients. Generation of mature/functional lung cells from iPSCs heavily relies on understanding of human lung development. …
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Multiomic Atlasing of Human Mesenchyme Development
Development of human connective tissue, termed ‘mesenchyme’, is a dispersed process in utero involving a diversity of cell lineages across organ systems. Diseases of these cell lineages, including fibroblasts and cartilage, affect numerous organ systems throughout human lifespan, manifesting as …
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Development Of Single-Cell Transcriptomic & Epigenomic Sequencing Technologies To Assess Cell-Type-Specific Gene Regulatory Programs In Mammalian Brains
Recent efforts to develop single-cell technologies have played a pivotal role in our ability to gain a high-resolution understanding of how tissue heterogeneity impacts human health, development, and disease. These technologies have become so powerful and popular in such a short period of time, and …
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Single-cell atlasing of the human tissues across the lifespan
Single-cell and spatial sequencing have revolutionised our understanding of human tissue biology in recent years. The Human Cell Atlas (HCA) initiative aims to recover and position all of the cell types in the human body. Being part of HCA, I have worked on building atlases which allow comparison …
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Single-cell Protein-Transcriptome Atlas of Haematopoiesis across the Human Lifespan
… the continuous production of stem and progenitor cells, which divide and mature to produce a wide variety of specialised circulating blood cells. Proper regulation of lineage decisions is key to ensure the right balance between the generation of differentiated cells and the maintenance of the …