Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 186 for “"Human Breast Cancer"”.
-
Antitumor activity of antimalarials in human breast cancer cells
… These data demonstrate that quinidine is a breast tumor cell differentiating agent that causes the loss of HDAC-1 via a proteasomal sensitive mechanism. Moreover, to determine whether effects of quinidine on cell differentiation and apoptosis is generalizable to quinoline antimalarials, we …
-
Cytochrome P450 mRNA profile in human breast cancer cell lines.
Cytochrome P450 enzymes (P450s) are involved in cancer development and treatment due to their roles in the oxidative metabolism of various compounds, both endogenous (e.g. oestrogen) and exogenous (e.g. tamoxifen). Intermediate P450 metabolites derived from oestrogen metabolism are associated with …
-
Effect of Estradiol on xc- in Human Breast Cancer Cells
<p></p><p>Breast cancer is the most common cancer among women worldwide with hundreds of thousands of new cases diagnosed each year in the United States alone. The discovery of receptors has improved the specificity of diagnoses, enabling development of receptor specific treatments. The discovery …
-
Estrogen Receptor Dependent Gene Regulation in Human Breast Cancer Cells
… cellular functions including proliferation of breast cancer cells. These studies should assist in the development of novel targeted therapies for breast cancer prevention and treatment.
-
Pharmacological regulation of c-myc gene expression in human breast cancer cells
… arrest and inhibition of proliferation in MCF-7 human breast cancer cell line (Woodfork, K. et al., 1995). The goal of studies reported here was to understand the molecular mechanisms of c-myc gene regulation by quinidine. C-myc is one of the most common oncogene aberrations in breast cancers …
-
The Role of UNC-45 in Heart Development and Human Breast Cancer
… chaperone of body-wall muscle myosins. In human and other vertebrates, two UNC-45 genes code two UNC-45 protein isoforms: UNC-45A/a and UNC-45B/b. UNC-45A/a is expressed in all cell types, whereas UNC-45B/b only exists in heart and skeletal muscles. This thesis investigated the distinct …
-
Effect of cmvIL-10 on Exosome Production by Human Breast Cancer Cells
<p>Human cytomegalovirus (HCMV) is a ubiquitous virus that infects 70-90% of the general population, primarily the immunocompromised, but has been implicated in several forms of cancer, including breast cancer. Breast cancer is the second leading cause of cancer related deaths in women in North …
-
Heat shock protein 27 inhibition of apoptosis in human breast cancer cells
Cancer occurs when normal cells fail to die in response to various cell death signals. Normal eukaryotic cells exhibit two major forms of cell death--Necrosis and Apoptosis. Apoptosis can be triggered in cells by various agents. Studies have shown that an elevated amount of Hsp 27 protects cells …
-
The proteomic analysis of resistance to anticancer therapy in human breast cancer
Resistance to anticancer therapy represents a major barrier in the successful management of human breast cancer. The identification of novel biomarkers that correlate with treatment response would increase our understanding of the resistance mechanisms and may allow therapy to be tailored on an …
-
The Effect of Mebendazole and RAN Mediated Pathways on Human Breast Cancer Cells
Breast cancer is a prevalent form of cancer that affects millions of people worldwide, accounting for 25% of all female cancers and the second leading cause of cancer-related deaths in women, following lung cancer. Breast cancer metastasis to other body parts is expected, with bones, liver, lungs, …
-
Expression and Immunological Characterization of Herv-K Transmembrane Envelope Protein In Human Breast Cancer
<p>The human endogenous retrovirus K (HERV-K) <em>env</em> gene encodes envelope protein comprising surface (SU) and transmembrane (TM) domains. Having shown the exclusive expression of SU in human breast cancer and the stimulation of SU-specific immune responses in patients with breast cancer, our …
-
Heat shock protein 27 inhibition of the caspase cascade in human breast cancer cells
… of the caspase cascade is described in human breast cancer cells that were engineered to constitutively express HSP 27. HSP 27 directly bound to cytochrome c and inhibited the activation of caspase 9 and caspase 3. In the presence of an excess amount of cytochrome c, the caspase cascade …
-
The impact of hypoxia on nanomedicine uptake and efflux in human breast cancer cells
In women, breast cancer is the most frequently diagnosed neoplasm, with a recognised high mortality burden. Breast cancer cells adapt to the hypoxictumoral environment by undergoing changes in metabolism, cell signalling, endo-lysosomal receptor uptake and recycling. The resulting hypoxic …
-
Hormonal modulation of sex steroid hormone receptors and oncogenes in human breast cancer cells
Since sex steroids modulate breast tumor growth, and high levels of the HER-2/neu protooncogene protein may contribute to breast cancer metastasis, the effects of estrogen, progestin and hormone antagonists on the levels of estrogen receptor (ER), progesterone receptor (PR) and HER-2/neu mRNA and …
-
THE ROLE OF DMP1 IN HUMAN BREAST CANCER PROGNOSIS AND CYCLIN D1-INDUCED BREAST CANCER
… cyclin D1 that is frequently overexpressed in breast cancer. Cyclin D1 can either increase or decrease the transcriptional activity of Dmp1 depending the molecular contexts of the targeted genes. Although loss of Dmp1 significantly accelerated oncogenic neu induced mammary carcinogenesis in …
-
Exploiting Clausius-Mossotti Factor to Isolate Stages of Human Breast Cancer Cells: Theory and Experiment
… dielectrophoresis (cDEP) for isolation of breast cancer cell stages. The ability to selectively concentrate breast tumor cells from a non-transformed or normal cell population is the key to successfully detecting tumors at an early stage of growth and treating transformed cells before they …
-
The Effects of 1,25-Dihydroxyvitamin D3, Docosahexaenoic Acid and 5-Fluorouracil on Human Breast Cancer Cells
… have antiproliferative effects on a variety of human cancers, including breast cancer. Studies have shown that a combination approach to cancer treatment is more effective than any one treatment administered alone. In this study, human mammary epithelial cells from the MCF-7 cell line were …
-
Transcriptional regulation of glycosyltransferase genes in MCF-7 human breast cancer cell line following drug treatment
… patterns of glycosyltransferase (GT) genes in breast cancer cell line following the treatment with a large set of Food and Drug Administration (FDA) approved drugs. This is based on the understanding that aberrant glycosylation in breast cancer tumours stem from altered GT gene expression. A …
Page 1 of 10