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Showing 1 to 20 of 35 for “"Human African Trypanosomiasis"”.
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Discovery and development of diagnostic biomarkers for human African trypanosomiasis
<p>Human African Trypanosomiasis (HAT) or African Sleeping Sickness is a disease prevalent in many parts of Sub-Saharan Africa. HAT is a parasitic infection caused by two species, <em>Trypanosoma brucei gambiense</em> and <em>T. b. rhodesiense</em>. Clinical diagnosis is not sufficient as symptoms …
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Examination and management of human African Trypanosomiasis propagation using geospatial techniques
Human African Trypanosomiasis (HAT) is a vector-borne disease transmitted by the bite of the tsetse fly that results in high human morbidity and mortality. The propagation of the disease has been linked to environmental factors, and understanding the vector’s habitat is vital to its control. There …
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Factors influencing the spread and selection of drug resistance in Human African Trypanosomiasis
A growing problem with drug resistance in Human African Trypanosomiasis has necessitated the implementation of screening programmes to monitor for its spread. This thesis describes the study of several factors that can influence the selection and propagation of drug resistance in T. brucei. Human …
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Economic and social consequences of human african trypanosomiasis in Muchinga, Lusaka and Eastern provinces of Zambia
Human African Trypanosomiasis (HAT) causes severe economic production losses in humans due to loss of man power and death. In Zambia most of the studies that have been done have focused on analysing the parasite while none have been conducted to establish the economic consequences of the burden of …
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Prevalence of human African trypanosomiasis and its associated risk factors in Itezhi-tezhi district of Zambia.
Human African Trypanosomiasis (HAT) is a debilitating zoonotic disease caused by trypanosomes which are transmitted by tsetse flies of the genus Glossina. This study aimed to determine the prevalence and risk factors of HAT in Itezhi-Tezhi (ITT) District of Zambia through active surveillance. Human …
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Economic and social consequences of human african trypanosomiasis in Muchinga, Lusaka and Eastern provinces of Zambia
Human African Trypanosomiasis (HAT) causes severe economic production losses in humans due to loss of man power and death. In Zambia most of the studies that have been done have focused on analysing the parasite while none have been conducted to establish the economic consequences of the burden of …
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Epidemiological role of indigenous dogs in the transmission of animal and human African trypanosomiasis in Zambia: a case study of dogs from Mambwe District
In Zambia, African trypanosomiasis (AT) is endemic in tsetse-infested Mambwe district. Although cases are common in livestock, they are rarely reported in dogs. However, recent studies have detected trypanosomes in Zambian dogs. As a follow-up, the current research was designed to investigate what …
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A comparative study on the capacity of Health Workers and Health Centers to diagnise Human African Trypanosomiasis in Tsetse infected Chama and Mambwe Districts of Eastern Zambia
… and compare the levels of knowledge on Human African Trypanosomiasis (HAT), disease awareness among health personnel and factors affecting the diagnostic capacity of HAT in tsetse infested Chama and Mambwe districts of Eastern Zambia. Structured questionnaires were used to collect …
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An evolutionary genomics approach towards analysis of genes implicated in transmission of trypanosomes between tsetse fly and mammalian host
Human African trypanosomiasis is the world’s third most important parasitic disease affecting human health after malaria and schistosomiaisis. The world health organization estimates approximately 60 million people at risk in sub-Saharan Africa and up to 50,000 deaths per year caused by …
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Structure- based inhibitor design for key enzymes of <em>Tryposoma brucei</em>
<p>Human African trypanosomiasis (HAT) also known as sleeping sickness is caused by a subspecies of <em>Trypanosoma brucei</em>. These parasites are transmitted by tsetse flies and endanger over 60 million people in Sub-Saharan Africa. Untreated, sleeping sickness is fatal, causing at least 48.000 …
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Investigation of Nigerian Ethno-medicinal Plants as Potential Sources of Cytotoxic and Anti-plasmodial Compounds. Biological activity of Vitellaria paradoxa, Cyperus articulatus, Securidaca longepedunculata and semi-synthetic halogenated analogues of cryptolepine isolated from Cryptolepis sanguinolenta
… of diseases such as cancer, malaria, and human African trypanosomiasis. However, health burdens of such diseases still remain high, with drug resistance leading to failure of current medication. Therefore, there is a need for new treatments, and this project considers the potential of …
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Probing Orthologue and Isoform Specific Inhibition of Kinases using In Silico Strategies: Perspectives for Improved Drug Design
… between kinase orthologues for treatment in Human African Trypanosomiasis and structural morphology differences between two kinase isoforms that can potentially be exploited for cancer therapeutic design.
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Total Synthesis of the Actinoallolides and a Designed Photoaffinity Probe for Target Identification
… the genus Trypanosoma, the causative agents of human African trypanosomiasis (sleeping sickness) and Chagas disease, while exhibiting no observable cytotoxicity against the MRC-5 human cell line. The side effects associated with most current antitrypanosomal drugs mean that there is an urgent …
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A comparative genomics approach towards classifying immunity-related proteins in the tsetse fly
Tsetse flies (Glossina spp) are vectors of African trypanosome (Trypanosoma spp) parasites, causative agents of Human African trypanosomiasis (sleeping sickness) and Nagana in livestock. Research suggests that tsetse fly immunity factors are key determinants in the success and failure of infection …
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Small molecules with anti-trypanosomal and anti-leishmanial activity
Parasitic diseases such as Human African Trypanosomiasis (HAT), Chagas disease and Leishmaniasis cause thousands of fatalities each year. Current chemotherapy is based on drugs discovered over 60 years ago that are expensive and difficult to administer. The drug-pipeline is virtually dry and the …
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The Role of S-Adenosylmethionine Decarboxylase on Regulation of Polyamine and Trypanothione Metabolism in Trypanosoma Brucei
Trypanosoma brucei is the causative agent of Human African Trypanosomiasis (HAT), a fatal and neglected disease affecting Sub-Saharan Africa. Current therapeutics are limited for several reasons, underscoring the need for new and improved drugs. The polyamine/trypanothione pathway is essential for …
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Synthetic strategies for potential trypanocides
Human African trypanosomiasis (sleeping sickness) is a devastating disease which is endemic in parts of sub-Saharan Africa. It is caused by the protozoan parasite T. brucei, which are transmitted by the bite of infected tsetse flies. Although the disease is fatal if left untreated, there is a lack …
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Identification and Characterization of Drug Targets in the Pyrimidine and Purine Pathways of Trypanosoma brucei
… extracellular parasite Trypanosoma brucei causes Human African Trypanosomiasis (HAT), which is fatal if untreated. Current therapies result in severe side effects and require complex treatment regimens. In an effort to spur the development of effective, safe, and simple to administer drugs, my …
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Essentiality and Regulation of Deoxyhypusination in Trypanosoma brucei
Human African trypanosomiasis is caused by protozoan parasite Trypanosoma brucei. T. brucei and other trypanosomatids require spermidine for the formation of trypanothione, a unique thiol-redox factor. In other eukaryotes, spermidine is essential for the (deoxy)hypusination of eukaryotic initiation …
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Amino acid transporters & amino acid metabolism in Trypanosoma brucei brucei
The development of new drugs against Human African Trypanosomiasis is much needed due to toxicity, efficacy and availability problems with current drug treatments for this resurgent parasitic disease. Delivery of drugs into cells is an important determinant of therapeutic efficacy of drugs. An …
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