Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"HuNoV"”.
-
Pathogenesis, immunity, and prevention of human norovirus infection in gnotobiotic pigs
Human noroviruses (HuNoVs) are the leading cause of viral epidemic acute gastroenteritis and responsible for the deaths of over 200,000 children each year worldwide. HuNoV research has been hampered by the long absence of a readily reproducible cell culture system and a suitable small animal model, …
-
Identification of host cellular factors that regulate human norovirus replication
The human norovirus (HuNoV) is one of the most predominant causes of gastroenteritis, yet no suitable therapeutics are available for its control. Currently, our knowledge of the precise cellular processes that control its replication is limited. In this study, we used the virus replicon system in …
-
Study of enteric virus infection and parenteral vaccines in the gnotobiotic pig model
Human rotavirus (HRV) and human norovirus (HuNoV) are the most common causative agents of acute gastroenteritis- (AGE) related morbidity and mortality around the world. Gnotobiotic (Gn) pigs are the ideal large-animal model that allows for accurate, and precise, preclinical evaluation of vaccine …
-
Norovirus Translation and Replication
Human norovirus (HuNoV) is the leading cause of gastroenteritis worldwide. Despite the significant disease and economic burden, currently there are no licensed vaccines or antivirals. The understanding of norovirus biology has been hampered by the inability to cultivate HuNoV in cell culture. To …
-
Decontamination of food and food-processing surfaces from norovirus by cold atmospheric-pressure gaseous plasma
Human Norovirus (HuNoV) is a leading cause of acute foodborne gastroenteritis outbreaks and sporadic cases. The estimated burden of HuNoV on public health is 685 million and 20 million illnesses each year in the world and the US, respectively. This results in approximately $4.3 billion and $60.3 …
-
Influence of Enteric Microbiota on Human Rotavirus and Human Norovirus Infection, and Rotavirus Immunity in Gnotobiotic Pigs
… those in developing countries. Human norovirus (HuNoV) is a leading cause of acute gastroenteritis in all age groups worldwide, and no vaccines are commercially available. Further understanding of how enteric microbiota influences these viral diseases may identify therapeutic targets. In our …
-
Characterisation of the Mechanism of Norovirus VPg-Nucleotidylylation
… Lastly, I demonstrated the ORF3 UTR region of HuNoV RNA to be able to template MNV VPg nucleotidylylation, suggesting template and positional conservation between MNV and HuNoV. In summary, this work provides new key insights into VPg nucleotidylylation - a previously poorly characterised, but …
-
Studies of pathogenesis, innate immunity and therapeutics of human enteric viruses in gnotobiotic pigs
… a reliable Gn pig model of human norovirus (HuNoV) infection and disease, we determined the median infectious dose (ID50) of a GII.4 2006b variant in pigs. We also evaluated the effects of age and administration of the cholesterol-lowering drug simvastatin on susceptibility to NoV infection. …
-
Innate sensing and regulation during enteric caliciviruses infections
Several decades after the discovery of the human norovirus, with thousands of lives and billions of dollars lost, the lack of a robust cell culture system still severely hampers development of vaccines and therapeutics. This is likely in large part as a result of our limited understanding of the …