Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 13 of 13 for “"HtrA"”.
-
Allosteric activation of periplasmic HtrA proteases
… a signaling cascade initiated when DegS, an HtrA-family periplasmic protease, cleaves RseA, a transmembrane anti-sigma factor, causing downstream release of the [sgima]E sigma factor and transcription of stress-response genes. Each subunit of the DegS trimer contains a trypsin-like protease …
-
Roles of Group B Streptococcal membrane proteins in virulence and protection
… two GBS membrane proteins: the serine protease HtrA and the alpha-like surface proteins. Many bacterial pathogens encode homologs of high temperature response A (HtrA) serine proteases, which regulate virulence and stress responses. While the function of GBS HtrA was previously unknown, here I …
-
Antimicrobial Effectors Act Cooperatively to Stress Salmonella in the Macrophage Phagosome
… antimicrobial peptides (CAMPs) during infection, htrA-lacZ (Cpx-dependent) and rpoE-lacZ (RpoE-dependent) expression was compared in wild type and pmrA mutant backgrounds. The PmrA regulon is required to protect against CAMPs. The htrA fusion was specifically induced in the pmrA mutant during …
-
Characterization Of A Novel Interactor/substrate For The Pro-apoptotic Serine Protease Omi/htra2
OmiHtrA2 is a highly conserved mammalian serine protease that belongs to the HtrA family of proteins. Omi shares homology with the bacterially expressed heat shock protease HtrA, which functions as a protease at higher temperatures and a chaperone at lower temperatures. Additionally, Omi shares …
-
Rendimiento de diferentes métodos de PCR en el diagnóstico molecular de las rickettsiosis humanas transmitidas por garrapatas
… de PCR que amplifican los genes ADNr 16S, htrA, gltA, ompA y ompB para el diagnóstico molecular de rickettsiosis. Para ello estudiamos 72 muestras (sangre con EDTA, biopsias de piel y garrapatas) de 52 pacientes con rickettsiosis en fase aguda y confimada por PCR. Se realizaron PCRs …
-
Sex as a Biological Variable in Preclinical Animal Studies with an Infectious Disease Exemplar.
… C. difficile, High temperature requirement-A (HtrA). This body of work investigates the contribution of sex-associated biological factors to preclinical safety assessments, evaluating whether therapeutic responses differ between males and females across biological systems. Across multiple …
-
Generation of Baculovirus-Brucella Abortus Heat Shock Protein Recombinants; Mice Immune Responses Against the Recombinants, and B. Abortus Superoxide Dismutase and L7/L12 Recombinant Proteins
… release was induced by immunization with the HtrA-Ribi combination, no mice were protected against challenge. Priming with vaccinia virus-GroEl recombinant and boosting with purified baculovirus-GroEL protein-Ribi combination did not induce protection. Androstenediol did not enhance in vivo …
-
Extracytoplasmic stress response systems in S. Typhimurium
… further. The structural components of HtrA, an important ESR protein in S. Typhimurium, were analysed and finally work within this thesis was involved in the investigation of potential overlaps between both the RpoE and CpxAR systems. This led to the establishment of preliminary studies …
-
Novel Protein-protein Interactions Regulate The Proteolytic Activity Of The Pro- Apoptotic Serine Protease, Omi/htra2
Omi/HtrA2 is a mitochondrial serine protease with high homology to the bacterial HtrA proteins. Omi promotes caspase-dependent apoptosis by binding and degrading IAPs-inhibitor of apoptosis proteins. Omi can also induce caspase-independent apoptosis but the actual mechanism is still unknown. IAP's …
-
Mechanisms of Virulence Regulation in Porphyromonas gingivalis W83
… that the periplasmic serine protease, HtrA, and the newly identified RegT, may play a role in regulating the gingipains and/or growth of <em>P. gingivalis</em> under stressful environmental conditions. Immunoblot analysis of <em>P. gingivalis</em> challenged mice and/or periodontitis …
-
Biochemical and Genetic Characterization of Reduced Phosphorus Metabolism in Pseudomonas Stutzeri WM88
… analysis of the htx operon suggests that htrA encodes a novel member of the 2-oxoglutarate dependent dioxygenase enzyme family, htxBCDE encode a binding protein dependent hypophosphite transporter and that htxF-htxN encode the components of a Carbon-Phosphorus lyase for the degradation of …
-
Identifizierung und Charakterisierung von Proteasen der Photosynthesemembran
… stellt ein Mitglied der ubiquitär verbreiteten HtrA-Familie von Serinproteasen dar, deren Zahl sich in Arabidopsis auf mittlerweile vierzehn beläuft. Es besitzt die typische katalytische Triade der Familie, läßt jedoch die zumindest für die meisten charakterisierten Homologe typische sogenannte …
-
An exploratory study of Helicobacter suis control strategies
… H. pylori high-temperature requirement A gene (htrA). Sequences coding for outer membrane proteins involved in adhesion to gastric cells, such as H. pylori adhesin A (HpaA), HorB and some Hof members were present in H. suis as well. On the other hand, H. suis lacks homologs of several other H. …