Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"Ht3"”.
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5-HT3 Receptor Ligands and Their Effect on Psychomotor Stimulants
… produced by increasing dopamine levels. 5-HT3 serotonin receptors have been shown to indirectly affect dopamine levels. Therefore, the effect of the 5-HT3 receptor partial agonist, MD-354, on the actions of psychomotor stimulants was analyzed in mouse locomotor activity assays to determine …
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Die Kinetik des heteromeren 5-HT3-Rezeptors: Untersuchungen mit Patch-Clamp-Technik und Computersimulationen
Der 5-HT3-Rezeptor gewinnt zunehmend pharmakologische Bedeutung, z.B. hinsichtlich der Wirkmechanismen von Antidepressiva. Diese wirken u.a. als 5-HT3-Rezeptor-Antagonisten oder hemmen die präsynaptische Serotonin-Wiederaufnahme. Darüber hinaus werden 5-HT3-Antagonisten in der Therapie des …
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Dual Mechanism Analgesia-Enhancing Agents
… effects. Recent studies have shown that both 5-HT3 receptors and α2B- adrenoceptors play a role in antinociception. MD-354, N-(3-chlorophenyl)guanidine, has a high-affinity both for 5-HT3 and α2B- adrenoceptors and could be viewed as the first example of a rather selective 5-HT3/α2B- …
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Pharmacological Characterization of Prejunctional Serotonin Receptors in Mammalian Anterior Uvea
… bodies.|Agonists selective for 5-HT6/7, 5-HT3, 5-HTia, 5-HTib/id, 5-HT2 and non- selective agonists all caused concentration-related enhancement in evoked [3H]-5-HT release from bovine tissues with the following rank order of potency (as measured by equipotent concentration ratio): 5-CT > …
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The heteromeric 5-HT3A/B receptor:the effect of 5-HT3B subunits on receptor structure and ligand recognition
The 5-HT3 receptors are members of the cys-loop family of ligand-gated ion channels. Two functional subtypes are known, the homomeric 5HT3A and the heteromeric 5HT3A/B receptors, which exhibit distinct biophysical characteristics but are difficult to differentiate pharmacologically. Atomic force …
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Molecular pharmacology of an insect GABA receptor
… their potent insecticidal properties. The 5-HT3 receptor is a member of the Cys-loop receptor family and shows homology to RDL receptors. To explore different techniques for studying Cys-loop receptor function I assessed the functionality of two brain derived transcripts of the 5-HT3B subunit …
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The Physiological Role of Serotonergic Transmission in Adult Rat Taste Buds
… taste buds express only the 5-HT1A and 5-HT3 subtypes. The 5-HT1A subtype was found to be expressed in TRCs, while the 5-HT3 subtype is presumed to be expressed in postsynaptic neural elements. Further, 5-HT and the 5-HT1A receptor have been shown to localize in non-overlapping …
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Molecular genetic mechanisms of eosinophil activation in aspirin-exacerbated respiratory disease : Genetic mechanisms of eosinophil activation
… were constructed: HT1 [AT], HT2 [GT] and HT3 [GG]. There was no significant difference between asthmatics and NC. In association of IL5RA polymorphisms, there were no significant differences in the genotype and allele frequencies of the three polymorphisms among the three groups. The five …
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Studies into Amphetamine-Induced Unconditioned Behaviour in the Rat.
… and sulpiride) and a putative antipsychotic (a 5-HT3 antagonist, ondansetron) on open-field locomotor routes taken by rats following treatment with 3.5mg/kg amphetamine. Measures of stereotyped locomotion derived from image analysis were supported by a novel form of behavioural analysis based on …
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Prophylactic Ondansetron Administration to Attentuate Spinal Anesthesia-Induced Hypotension in Cesarean Section
… shown that 5-hydroxytryptamine subtype 3 (5- HT3) receptor antagonists can effectively reduce BJR activation. Ondansetron is a 5-HT3 receptor antagonist linked to a reduction in the frequency and severity of SAIH. Methods: A presentation of an educational session to improve anesthesia …
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Genetic association study of interleukin 6 receptor and liver X receptor in systemic lupus erythematosus
… were constructed: HT1 [GTA], HT2 [ATC], HT3 [ATA], HT4 [GTC] and HT5 [GAA]. There were no significant differences between SLE and NC. However, the frequency of rash (p=0.037), leukopenia (p=0.033) and lymphopenia (p=0.027) were significantly higher in SLE patients having the haplotype HT2 …
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Development of 'In vitro' intestinal models to study the pharmacology of drugs affecting the gastrointestinal tract in normal and diseased conditions. Development of a cell culture model for intestinal pharmacology.
… (5-HT2 receptor antagonist), granisetron (5-HT3 receptor antagonist) and RS 23597 (5-HT4 receptor antagonist) at 1¿M or a combination of ritanserin, granisetron, plus RS 23597 at 1¿M significantly reduced or abolished contractile responses induced by 5-HT. SB 269970A (5-HT7 receptor …
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Charakterisierung des 5-HT<sub>3B</sub>-Promotors der Ratte vor dem Hintergrund eines mit Chemotherapie-induziertem Erbrechen assoziierten Polymorphismus
5-HT3B ist eine Untereinheit des Serotoninrezeptors Typ 3 (5-HT3), einem Ionenkanal aus der Cys-loop-Rezeptorfamilie. Das Gen HTR3B kodiert für 5-HT3B. Der -100_-102delAAG-Polymorphismus im HTR3B-Promotor kann die HTR3B-Promotoraktivität beeinflussen und wurde mit Häufigkeit und Schweregrad von …
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Genetic Effect of ALOX15 Polymorphisms on Aspirin-Exacerbated Respiratory Disease
… was significantly higher compared to that of ht3 [AG] construct in A549 and U937 cells (P<0.001, respectively). Moreover, -427 G specific binding protein was observed by EMSA. The AERD patients with the -427G allele had higher 15-LO activity and the metabolites of 15-LO in RBC lysates. …
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Evaluation of race population distribution, fungicide sensitivity, and fungicide control of Exserohilum turcicum, the causal agent of northern leaf blight of corn
… on corn differential lines containing Ht1, Ht2, Ht3, Htm1, and Htn1 resistance genes. Isolates were collected from fields in Illinois, Indiana, Iowa, Minnesota, North Carolina, Ohio, and Wisconsin, including: 143 isolates collected between 2007 and 2014; and 13 isolates collected between 1979 and …
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Significant Association of IL-18 Genetic Polymorphisms with Aspirin-Intolerant Urticaria in a Korean Population
… than those with other haplotypes, HT2 [AG] or HT3 [AC] in two different cells including HMC-1 and Beas2B. EMSA finding showed that CREB2 bound more tightly to the -607C allele sequence than to the A allele sequence by EMSA. Moreover, subjects significantly increased neutrophil chemotaxis …
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Neuronal plasticity in the enteric nervous system motor pathways
… at muscarinic receptors, 5-HT or ATP acting at 5-HT3 or P2X receptors (respectively), but may have depended upon an increased excitability of enteric neurons. Thus, neuronal plasticity of the enteric nervous system is highly adaptable and able to compensate for inhibition of multiple receptors in …
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Mechanisms of pain processing: spinal protein translation in the rat
… activating or blocking serotonergic spinal 5-HT3 receptors. These pathways have already been proven to be pivotal in the maintenance of persistent pain-like states. The results suggest that mTOR has a continuous role in maintaining persistent pain-like states via rapid local protein …
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