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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 26 for “"Ht2"”.

  1. Predicción de actividad inhibitoria de moléculas pequeñas sobre el receptor serotoninérgico 5 HT2 A mediante modelos de machine learning

    Rojas Mena, Aramis AdrianaUniversitat Oberta de Catalunya (UOC)2020

    … pequeñas sobre el receptor serotoninérgico 5-HT2A. Este receptor se asocia a patologías psiquiátricas ya conocidas, para las cuales existe tratamiento con moléculas pequeñas que lo inhiben, pero con frecuentes efectos adversos. Se prueban algoritmos tanto de clasificación como de regresión, …

    catalunya Repository record

  2. Small Molecule Allosteric Modulation of G Protein-Coupled Receptors and Applications in the Pharmacological Targeting of 5-HT2 Receptors

    Wold, Eric A.The University of Texas Medical Branch at Galveston2021

    … modulator discovery for the serotonin 5-HT2C receptor (5-HT2CR). From the time of its characterization, the 5-HT2CR has been marked by unique, untapped potential as a drug discovery target for numerous diseases and disorders of the central nervous system. Thus, the second chapter in this …

    utmb Repository record

  3. The synthesis of 5-HT2 receptor designed multiple ligands to investigate the role of the 5-HT2AR and the 5-HT2CR in cocaine addiction

    Shashack, Matthew 1981-The University of Texas Medical Branch at Galveston2016

    Previous studies indicate that the 5-HT2AR and 5-HT2CR play a role in cocaine induced behavior modification through either stimulation or inhibition respectively. Recent research has revealed that dimerization and oligomerization of GPCRs including the 5-HTRs frequently occurs. In order to target …

    utmb Repository record

  4. Characterization of 5-Hydroxytryptamine-Evoked Isometric Contractile Responses in Aortic Vascular Smooth Muscle in Thyropathological Rats

    Edgington, Nicholas P.Drake University1992

    … in the presence or absence of ketanserin (5-HT2 antagonist) and ICS 205-930(5-UT3 antagonist). Flndings. 5-HT generated a nonsignificant trend toward increased contractile tension in TRX rats, but a significant reduction in contractile tension in rings from PTU rats. These differences were …

    drake Repository record

  5. Promoter Polymorphisms of Cysteinyl Leukotriene Receptor 1 (CysLTR1) Influence the Effect of Leukotriene Modifier on Transcriptional Regulation of the CysLTR1 Gene Induced by IL-4

    오, 정미2011

    … AIA vs. NC; p=0.022 for AIA vs. ATA), and the ht2 [T-C-G] haplotype with increased disease risk (p=0.031 for AIA vs. NC; p=0.031 for AIA vs. ATA). Moreover, 3 SNPs can modulate CysLTR1 gene expression; promoter activity was enhanced with ht2 [T-C-G] construct in comparison of ht1 [C-A-A] …

    ajou Repository record

  6. Molekulare und pharmakologische Charakterisierung von Serotonin-Rezeptoren der Honigbiene Apis mellifera

    Schlenstedt, JanaUniversität Potsdam

    … die größte Ähnlichkeit zu dem 5-HT7- und 5-HT2-Rezeptor von Drosophila melanogaster bzw. dem 5-HT1-Rezeptor von Panulirus interruptus auf. Die isolierten Serotonin-Rezeptoren der Honigbiene wurden dementsprechend Am(Apis mellifera)5-HT1, Am5-HT2 und Am5-HT7 benannt. Das Hydropathieprofil des …

    potsdam-diss Repository record

  7. Charakterisierung der Serotonin-Rezeptoren in den Speicheldrüsen von Calliphora vicina

    Röser, ClaudiaUniversität Potsdam

    … Klonierungsstrategien zwei cDNAs (Cv5-ht2α und Cv5-ht7) isoliert, die große Ähnlichkeit zu 5-HT2- und 5-HT7-Rezeptoren aus Säugetieren aufweisen. Die Hydropathieprofile der abgeleiteten Aminosäuresequenzen postulieren die für GPCRs charakteristische heptahelikale Architektur. Alle …

    potsdam-diss Repository record

  8. Regulation of dorsal raphe serotonergic neurons by histamine

    Panetta, Kara MarieUniversity of Dundee2014

    … regulatory control by α1-adrenoreceptors, 5-HT2 receptors, orexin receptors and histamine receptors. In vitro, patch-clamp studies were performed in order to extend the investigation of 5-HT2, orexin and histamine receptors further in the hope of understanding the cellular mechanisms …

    dundee Repository record

  9. Genetic Effect of MBL2 Polymorphisms in Patients with Diisocyanate-induced Occupational Asthma

    배, 수진2013

    … carrying the GG genotype at -225 G>C, and ht2 [CAG] had significantly lower PC20 methacholine levels (P=0.030, and P<0.001, respectively) than non-carriers. Serum MBL levels were significantly higher in DI-exposed subjects (including both DI-OA and AEC) carrying the GG genotype of -554 G>C …

    ajou Repository record

  10. Genetic association study of interleukin 6 receptor and liver X receptor in systemic lupus erythematosus

    전, 자영2012

    … three polymorphisms were constructed: HT1 [GTA], HT2 [ATC], HT3 [ATA], HT4 [GTC] and HT5 [GAA]. There were no significant differences between SLE and NC. However, the frequency of rash (p=0.037), leukopenia (p=0.033) and lymphopenia (p=0.027) were significantly higher in SLE patients having the …

    ajou Repository record

  11. The role of hyperpolarization-activated non-selective cation current in amygdala excitability and serotonin mediated effects.

    Herman, David Hans.Baylor University.2007

    … can reduce Ih¬, possibly through activation of 5-HT2 receptors. Overall, the results suggest that Ih may be an important new target for pharmacological treatment of psychiatric disorders involving the amygdala.

    baylor Repository record

  12. Molecular genetic mechanisms of eosinophil activation in aspirin-exacerbated respiratory disease : Genetic mechanisms of eosinophil activation

    Purevsuren, Losol2013

    … two polymorphisms were constructed: HT1 [AT], HT2 [GT] and HT3 [GG]. There was no significant difference between asthmatics and NC. In association of IL5RA polymorphisms, there were no significant differences in the genotype and allele frequencies of the three polymorphisms among the three …

    ajou Repository record

  13. Charakterisierung der Serotonin-Rezeptoren der Honigbiene Apis mellifera : von den Genen zum Verhalten

    Thamm, MarkusUniversität Potsdam

    … sich dabei um einen 5-HT1- (Am5-HT1) und zwei 5-HT2-Rezeptoren (Am5-HT2α und Am5-HT2β) handelt. Die strukturelle Analyse der abgeleiteten Aminosäuresequenz dieser Rezeptoren postuliert das Vorhandensein der charakteristischen heptahelikalen Architektur von GPCRs und zeigt starkkonservierte …

    potsdam-diss Repository record

  14. The ontogeny and functional distribution of novel, neurochemically-defined columns in mammalian visual cortex

    Dyck, Richard H.University of British Columbia1993

    … around postnatal day (PD) 30, while 5-HTic and 5-HT2 receptors exhibited peak levels in middle cortical layers at PD50 and PD120, respectively. Between PD30 and PD90, 5-HTic & 5-HT2 receptors were expressed at high levels within the same columnar compartments, but within different …

    ubc Repository record

  15. Evaluation of race population distribution, fungicide sensitivity, and fungicide control of Exserohilum turcicum, the causal agent of northern leaf blight of corn

    Weems, Japheth DrewUniversity of Illinois at Urbana-Champaign2016

    … on corn differential lines containing Ht1, Ht2, Ht3, Htm1, and Htn1 resistance genes. Isolates were collected from fields in Illinois, Indiana, Iowa, Minnesota, North Carolina, Ohio, and Wisconsin, including: 143 isolates collected between 2007 and 2014; and 13 isolates collected between …

    uiuc Repository record

  16. The association between testosterone and muscle mass, muscle strength, and physical function in Korean men aged 60 and older

    오, 소현2013

    … by muscle mass adjusted by height (ASM/ht2), muscle strength, and gait speed. However, muscle mass adjusted by body weight (ASM/wt) had significant relationship with serum testosterone.

    ajou Repository record

  17. Development of 'In vitro' intestinal models to study the pharmacology of drugs affecting the gastrointestinal tract in normal and diseased conditions. Development of a cell culture model for intestinal pharmacology.

    Batista Lobo, SamiraUniversity of Bradford2010

    … (5-HT1/2/5-7 receptor antagonist), ritanserin (5-HT2 receptor antagonist), granisetron (5-HT3 receptor antagonist) and RS 23597 (5-HT4 receptor antagonist) at 1¿M or a combination of ritanserin, granisetron, plus RS 23597 at 1¿M significantly reduced or abolished contractile responses induced by …

    bradford Repository record

  18. Significant Association of IL-18 Genetic Polymorphisms with Aspirin-Intolerant Urticaria in a Korean Population

    손, 진경2011

    … activity than those with other haplotypes, HT2 [AG] or HT3 [AC] in two different cells including HMC-1 and Beas2B. EMSA finding showed that CREB2 bound more tightly to the -607C allele sequence than to the A allele sequence by EMSA. Moreover, subjects significantly increased neutrophil …

    ajou Repository record

  19. Cerebral Microcirculatory Effects of Maturation

    Elliott, Scott R.

    … and adult sheep middle cerebral arteries, 5-HT2 serotonergic receptors mediate contractile responses to serotonin and that alpha-1 adrenergic receptors mediate contractile responses to norepinephrine. In addition, tissue sensitivity to 5-HT and NE decreases significantly with maturation, but …

    loma-linda Repository record

  20. Protein-Protein Interactions with Serotonin G Protein Coupled Receptors: Novel Targets for Neurotherapeutics Drug Discovery

    Soto, Claudia AlejandraThe University of Texas Medical Branch at Galveston2018

    … data of two PPIs within the serotonin (5-HT) 5-HT2 receptor (i.e., 5-HT2CR and 5-HT2AR) system which may be promising targets for the treatment of neuropsychiatric disorders. The 5-HT2CR has been implicated in anxiety, binge eating disorder, depression, impulsivity, movement disorders, obesity, …

    utmb Repository record

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