Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Hsp70 chaperones"”.
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Assessing the role of Hsp70 in prion propagation in Saccharomyces cerevisiae
… of yeast prions require the function of protein chaperones and co-chaperones. The heat shock proteins (HSP) such as Hsp40, Hsp70 and Hsp104, are essential for prion propagation in yeast. Hsp70 is a highly conserved protein composed of an N-terminal ATPase domain, a peptide-binding domain (PBD) …
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On chaperone co-operation in temporal and spatial protein quality control
… PQC networks across all kingdoms of life are the Hsp70 molecular chaperones. In my thesis I present work into the adaptability of the chaperone network during different types of stress, and the functional variability between highly homologous yeast Hsp70 chaperones. During heat stress, Hsp70s …
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Functional dissection of the S. cerevisiae helicase activating factor Cdc45
… Cdc45 mutants were found to be associated with Hsp70 chaperones, and subsequently failed to fully restore in vitro replication in a Cdc45-dependent biochemical assay. Co-immunoprecipitation studies revealed an interaction of Cdc45 with Sd3 and S1d7 and mapped a Cdc45 region that interferes with …