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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"Hsp60"”.
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Peptide Antisera Generation against Three <em>Chlamydia trachomatis</em> Hsp60 Homologues to Examine Expression of each Hsp60 during Iron Restrictive Growth.
… trachomatis</em> heat shock protein 60kDa (chsp60) exhibits increased expression in response to iron limitation. Genome sequencing revealed three genes encoding chsp60s. The objective of this study was to generate peptide antisera that would selectively recognize each chsp60. The DNA sequence …
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Studies on the Function of Human Anti-HSP60 Monoclonal Antibody Fab
… 기법을 이용하여 인간 재조합 항-열충격 단백질-60에 대한 단클론 항체 Fab (HSP60-45)를 제작하였다. 본 연구에서는 HSP60-45 항체가 HSP60에 의하여 자극을 받은 대식세포에 의하여 방출되는 종양 괴사 인자-a, 인터루킨-6, NO의 방출 양상에 미치는 영향 분석을 통하여, 이 항체의 염증 반응 조절에서의 잠재적 기능을 연구하고자 하였다. 재료 및 방법 : 항-열충격단백질-60 Fab 클론, HSP60-45를 박테리아에서 발현시킨 후, Ni-NTA agarose 친화성 크로마토그래피를 이용하여 용해성 …
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The role of Hsp60 in Amyloid beta toxicity: Relevance to Alzheimer’s disease
… Here, we focused on the mitochondrial chaperone Hsp60, which is known to protect mitochondria from misfolded proteins. Evidence suggests that Hsp60 directly interacts with APP/Ab in vitro, and this interaction could contribute to protecting mitochondria from Ab-induced damage. However, weather …
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The role of Hsp60 in Amyloid beta toxicity: Relevance to Alzheimer’s disease
… Here, we focused on the mitochondrial chaperone Hsp60, which is known to protect mitochondria from misfolded proteins. Evidence suggests that Hsp60 directly interacts with APP/Ab in vitro, and this interaction could contribute to protecting mitochondria from Ab-induced damage. However, weather …
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Biophysical Characterization of the Interaction between the Universal Stress G4LZI3 protein and Schistosoma mansoni Hsp60 Substrate Binding Domain
… the S.mansoni G4LZI3 protein and the S.mansoni Hsp60, this requires understanding the structure of the two proteins and their preferred orientation upon interaction. Employment of various bioinformatics tools in this study helped in bringing insight on the structure of both proteins, their …
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Recent Developments of Chlamydia trachomatis and Mycoplasma Infections in Women
… We also investigated the correlation between c-hsp60 antibodies and h-hsp60. C.trachomatis DNA could not be detected in any of the tubal tissue specimens from our patients with EP although highly sensitive diagnostic methods were used. Prior EP /PID was associated with ct-hsp60 antibodies but …
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Expression différentielle des protéines de choc thermique en réponse à diverses conditions chez le doryphor de la pomme de terre Leptinotarsa decemlineata
… des protéines de choc thermique, telles que HSP60, HSP70, HSP90, dans la réponse à divers stress chez L. decemlineata. L'approche par ARNi ciblant HSP60 a également révélé une hausse substantielle de la létalité chez les insectes dont les niveaux endogènes de cette cible étaient réduits. En …
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Identifikation von Interaktionsproteinen des humanen MxA-Proteins und Untersuchung der inhibitorischen Wirkung von Mx-Proteinen auf die Replikation des Influenza-A-Virus
… Proteinen konnten das Hitzeschock-Protein Hsp60 und b-Tubulin mittels MALDI-TOF-MS Peptid-Fingerprint-Analyse als potentielle Interaktoren von FLAG-MxA identifiziert werden. Während Hsp60 als Chaperon wahrscheinlich am Faltungs-prozess von neu synthesiertem MxA beteiligt ist, könnte Tubulin …
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Evaluation of five bifidobacterium isolates as potential probiotics and genetic analysis of their ability to withstand oxidative stress
… rRNA gene spacer region, the heat shock protein (hsp60) and Elongation factor Tu (tuf).
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Effects of Vitamin D on Expression of Toll-like Receptors of Monocytes from Patients with Behcet's Disease
… manner. TNF-α synthesis upon LPS, LTA and HSP60 stimulation was also decreased in 1,25(OH)2D3 treated monocytes in concordance with TLR2, TLR4 down-regulation. And the marked increase of TNF-α response to TLR2, TLR4 ligands was found in active BD monocytes when compared to normal, which was …
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Proteomic analysis of cellular models of neurodegeneration and mitochondrial dysfunction
… in the levels of 60 kDa heat shock protein (Hsp60), heat shock cognate 71 kDa protein (Hsc70), glutamate oxaloacetate 2 (GOT2) and voltage-dependent anion channel 1 (VDAC1) were validated as potential markers of MPTP-induced toxicity using western blot analysis. In parallel, a study of the …
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The exercise-induced expression of heat shock proteins in human skeletal muscle : the role of evaluated muscle and core temperature and the influence of training status
… variable increases in HSP70, HSC70 and HSP60 content with peak increases typically occurring at 48 h post-exercise. In contrast, exercise did not induce significant increases in either HSP27, aB-crystallin, manganese superoxide dismutase (MnSOD) protein content or the activity of …
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Molecular Characterization of the Heat Shock-Regulatedgroesl Operon in Lactobacillus Zeae Strain 102S
… highly conserved shock response genes groESL (HSP60/10). A rapid RNA isolation procedure was developed, and specific heat induction conditions for the groESL operon were determined by Northern and slot blot analyses. Changes in the level of the molecular chaperone GroEL (HSP 60) were analyzed …
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Interaction of Detergents and Disinfectants upon Surface Adhered Populations of Escherichia coli and Listeria monocytogenes
… expression of the stress response proteins, HSP60 and HSP70, at differing levels of expression after the same contact time and against different states of adherent populations, i.e. 1-hour attached or 24-hour biofilm populations.
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The heat-shock response in <i>Serpula s</i>pecies at the cellular and molecular level
… related to the heat-shock response, namely hsp60, hsp70 which have been shown in other eukaryotic systems to play key roles in this response. Secondly, immunological studies were also used to detect changes in the pattern of protein ubiquitination, which resulted from heat stress. Thirdly, …
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Antibody Response to Trypanosoma Cruzi During the Course of Infection in Mice Held at Elevated Environmental Temperature
… shock proteins (Hsp), typically Hsp90, Hsp70 and Hsp60, that are highly immunogenic. It was of interest, therefore, to determine whether different parasite antigens are produced by T. cruzi at different temperatures, and if so, whether these antigens would be recognized by antisera from mice held …
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Mitochondrial Unfolded Protein Response Regulator Atf5 In Mitochondrial Targeted Therapies In Aml
… specific chaperones and proteases such as HSP60, LonP1 and ClpP, aiding in the restoration of mitochondrial protein pool homeostasis. However, the cell-protective roles of UPR<sup>mt</sup> in the context of mitochondrial stress-induced cell death in AML has not been well explored. We …
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Charakterisierung des Chaperons Mdg1 unter Berücksichtigung der subzellulären Lokalisation und Identifizierung der Interaktionspartner mit Hilfe des Yeast-Two-Hybrid-Systems
… in Klassen der Hsp100-, Hsp90-, Hsp70-, Hsp60-, Hsp40- und die der kleinen Hitzeschockproteine (sHsp) eingeteilt. <br>Ein neues Mitglied der Hsp40-Chaperone wurde 1996 bei der Untersuchung der molekularen Mechanismen der Angiogenese entdeckt und mikrovaskuläres Differenzierungsgen 1, …
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Gpi-Anchored Proteins In Ciliated Protozoa: From Ca++ Signaling To Mitochondrial Extrusion
… imaging in conjunction with antibodies against HSP60 and ATP synthase, extruded mitochondria were shown to co-localize with plasma membrane blebs. Mitochondrial extrusion appears to be Ca++ dependent and can be induced in response to heat shock. Cells survive the response and regain their normal …
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