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Showing 1 to 2 of 2 for “"Hsc70Cb"”.
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Deciphering The Role of Hsp110 Chaperones In Diseases of Protein Misfolding
… has shown that loss of the sole Hsp110 gene (Hsc70Cb) accelerates the aggregation of polyglutamine-expanded human huntingtin (HTT), the causative agent of Huntington’s disease; while its overexpression protects against polyQ-mediated neuronal cell death. I hypothesize that in addition to its …
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Analysis of The Biochemical and Cellular Activities of Substrate Binding By The Molecular Chaperone Hsp110/Sse1
… by the <em>Drosophila melanogaster</em> Hsp110, Hsc70cb. As a major partner of Hsp70, determining cellular Hsp110 activities is a prerequisite to a full understanding of chaperone-mediated protein homeostasis. By studying chaperone functions and activities in yeast and animal models, we can …