Global ETD Search
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Showing 1 to 4 of 4 for “"HoxA13"”.
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Investigating the role of HOTTIP, HOXA13 and PSIP1 in cancer.
… locus and regulates nearby HOXA genes including HOXA13 in cis. It has previously been shown that HOTTIP and HOXA genes are regulated by the oncogenic PSIP1 protein. Using both siRNA mediated knockdown and CRISPR-Cas9 mediated genetic knockout approaches, the role of HOTTIP, HOXA13 and PSIP1 were …
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The Effects of Mutations in Hoxa13a, Hoxa13b, and hHoxd13a on the Zebrafish Fins
… spiny rays during acanthomorph fin development. Hoxa13 -/-, Hoxd13 -/- mice completely lack the autopod in their developing limbs. The function of the fish orthologs hoxa13a, hoxa13b, and hoxd13a are not as well defined in fin ray development, although clear structural changes to the fin rays …
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Skeletal element elongation and interdigital tissue regression in developing bat limbs: a gene expression analysis
… interdigits, and did not correspond with Hoxa13 expression, which was reduced in the forelimb. Autopod expression was independent of retinoic acid (RA) signalling, with genes involved in RA synthesis ( Rdh10 , Aldha2 ) , degradation ( Cyp26b1 ) and signalling (Rar β) expressed in bat …
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Studying the Patterning Mechanisms and Cell Fates during Limb Regeneration in Ambystoma mexicanum
We studied patterning mechanisms and cell fates during limb regeneration in the axolotl. 1) It is crucial to understand the earliest events of patterning. Since it is technically challenging to study early events, we established single cell PCR. This new tool will allow us to obtain novel insight …