Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 4 of 4 for “"Hot-melt mixing"”.
-
Hot-melt mixing of partially miscible active pharmaceutical ingredient-polymer mixtures
… producing pharmaceutical oral dosages such as hot-met extrusion (HME) have received increasing attention by industry and academe because they can enhance drugs' solubility and even bioavailability to a great extent by converting drugs from crystalline to amorphous form. HME can be carried out …
-
Foaming of amorphous drug delivery systems prepared by hot melt mixing and extrusion
… Ingredient (API) and Polymer excipient. The Hot Melt Extrusion (HME) process is used to compound the following API / polymer binary systems: Indomethacin (INM) with Soluplus (PVCap-PVAc-PEG); Carbamazepine (CBZ) with PVCap-PVAc-PEG; and INM with Eudragit EPO. Comprehensive characterization of …
-
The effect of nanoclays on the properties of aspirin modified enteric polymer prepared by hot-melt mixing
Melt mixing in batch equipment or continuous extruders is a technique that recently gained the attention of the pharmaceutical industry. This dissertation investigates two controlled-release drug delivery systems. The first system, namely the enteric matrix, contains an active pharmaceutical …
-
Study of controlled release of active pharmaceutical ingredients from functionalized nanoclays and polymer matrices
… or immiscible systems prepared by different mixing methods. The selected APIs have low solubility at the low pH of the aqueous medium and different solubility parameters by comparison with the polymer. The Eudragit E100/ DIK-Na+ mixture produced by batch melt mixing showed an API solid …