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Showing 1 to 20 of 64 for “"Hot-melt extrusion"”.
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Hot-melt extrusion: A versatile pharmaceutical technology
Hot-melt extrusion (HME) is a promising technology for the production of new chemical entities in the developmental pipeline and for improving products already on the market. The first objective of this research work was to describe a continuous process for the production of solid lipid …
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Novel Applications of Hot-Melt Extrusion Technology
Hot-melt extrusion, an adaptable technology, has established its position in a wide spectrum of manufacturing operations like amorphous solid dispersions, immediate and controlled oral formulations, implants, and taste masked products. In recent years the industrial focus has shifted towards …
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Patient Friendly Formulations Utilizing Hot Melt Extrusion Technology
This research work exhibited the new outlook of hot melt extrusion technology for orally disintegrating tablet, fast disintegration films and fixed dose combinations. Previous research demonstrated these applications by conventional formulation techniques which has inherent shortcoming of use of …
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Versatility of hot-melt extrusion for dosage form design
Recently, Hot Melt Extrusion (HME) has attracted the attention of pharmaceutical companies and scientists as a technique for manufacturing a variety of dosage forms. In this research, HME was applied in different ways to achieve different goals, such as solubility enhancement, taste masking, solid …
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Physicochemical characterization of solid dispersions prepared using hot-melt extrusion technology
… the physicochemical properties of the prepared melt extrudates by different analytical techniques. Hot melt extruded solid dispersions of BL were prepared using polyethylene oxide (PEO) or polyvinylpyrrolidone (PVP) as hydrophilic carriers, whereas PVP or Eudragit 4155F was used to prepare the …
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The kinetics of drug dissolution in polymers during hot-melt extrusion
Extrusion has been a most important and widely used continuous process in polymer processing for over one hundred and fifty years. However, it has only been recently applied and adopted by the pharmaceutical industry to prepare solid oral dosage formulations with increased bioavailability for the …
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Dispersion and dissolution kinetics of API particles in pharmaceutical hot melt extrusion
Pharmaceutical Hot Melt Extrusion (HME) is essentially a special case of polymer compounding. The elementary steps involved in traditional plastics melt processing are handling of particulates, melting, dispersive and distributive mixing, devolatilization and stripping, and finally pressurization …
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Development and Characterization of Sustained-Release Formulations via Novel Hot Melt Extrusion Techniques
Hot melt extrusion (HME) is a leading technology that can be applied to many pharmaceutical preparations as solid dispersions. Part of this research project focus on injecting pressurized carbon dioxide (P-CO2) gas during the HME process. These combined techniques have an additional advantage of …
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Characterization of different hydrophilic polymers and their applicability in hot melt extrusion technology
… necessary to utilize a novel technology such as hot melt extrusion (HME) in combination with hydrophilic polymers to obtain tailored drug release. Over recent years HME technology has found widespread application as a viable drug delivery option in the drug development process. Some of the HME …
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Crystalline Salt Formation of an Acidic Drug Indomethacin Using Hot Melt Extrusion Technology
… water-soluble drug) can be increased by using hot melt extrusion of a 1:1 (mol/mol) indomethacin:tromethamine mixture to form a highly crystalline salt, the physicochemical properties of which are investigated in detail. Specifically, pH–solubility studies demonstrated that this salt exhibited …
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Preparation And Evaluation Of Valacyclovir Hydrochloride Ocular Inserts By Hot Melt Extrusion Technique
… study was to investigate the processability of Hot Melt Extrusion to formulate Ocular Inserts of Valacyclovir Hydrochloride and Evaluate its drug release in vitro and in vivo. Valacyclovir is the prodrug of Acyclovir, which is used in treatment of ocular keratitis and HSV infections. The …
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Assessment of a marine polysaccharide for use as excipient in pharmaceutical hot-melt extrusion
Pharmaceutical Hot Melt Extrusion (HME) is currently investigated by both industry and academia as a method for manufacturing solid oral dosages with improved bioavailability of poorly-water soluble active pharmaceutical ingredients (APIs) and control drug release of water-soluble APIs. Although …
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Influence of hot melt extrusion processing parameters on the properties of a pharmaceutical formulation
Hot melt extrusion (HME) is an old technology that has been recently adapted to be used in the pharmaceutical industry. HME is a continuous process that is widely used to produce a solid dispersion matrix. The aim of this dissertation is to evaluate different factors that will affect the …
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Hot melt extrusion (HME) processing for the development of lipid oral solid dosage forms
This research study explores the use of lipids in hot melt extrusion (HME) for the preparation of sustained release solid lipid matrices. The use of lipids instead of polymers is a novel approach with distinct advantageous. Sustained release solid lipid matrices of diclofenac sodium …
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Continuous manufacture of enabling formulations for a poorly soluble compound using hot melt extrusion technology
Over the past few decades, hot melt extrusion has emerged as a tremendously useful and versatile technology within pharmaceutical research and development. As a well-established technique in the production of oral solid dosage formulations, its operating capacity has the capability to address …
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Influence of novel techniques on solubility, mechanical properties and permeability via hot melt extrusion technology
Hot melt extrusion (HME) was evaluated as a continuous processing technology for the manufacture of solid dispersions. The aim of the current research project was to study the effect of pressurized carbon dioxide (P-CO2) on the physico-mechanical properties of three different grades of cellulose …
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Solubility Enhancement and Precipitation Inhibition of Poorly Water Soluble Compounds Utilizing Hot Melt Extrusion Technology
… felodipine (FEL) or ketoconazole (KTZ) using hot-melt extrusion technology. The melting point depression approach was utilized to determine the miscibility and solubility of the model compounds within Soluplus® , of which felodipine demonstrated higher solubility when compared to ketoconazole …
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Hot-melt extrusion as processing technique for multiparticulate dosage forms containing lipophilic and hydrophilic polymers
… and continuous procesesing technique (i.e. hot-melt extrusion) a multiparticulate dosage form with zero-order sustained-release properties. This study demonstrated that the in vitro and in vivo drug release kinetics could be varied by selecting a formulation with an appropriate ratio of …
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Design and development of drug delivery systems for immediate and sustained release utilizing hot melt extrusion
… profile during formulation development for HME (Hot melt extrusion). Many commercially available, pharmaceutical-grade polymers can be used in HME formulations. The suitable polymer choice facilitates processing in the extruder. When choosing a polymer to use in a formulation, processing …
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Development of cocrystals of water insoluble active substances with inactive excipients by using hot melt extrusion
… reported herein was to develop and optimise hot melt extrusion (HME) as a robust technique for the cocrystallisation of poorly water soluble drugs and their coformers. Two pairs of cocrystals of a poorly water soluble drug, carbamazepine, with saccharin and trans-cinnamic acid, were produced …
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