Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Host-targeted"”.
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Viral- and host-targeted interventions to improve influenza disease outcomes
… disease from two perspective; the virus and the host. The influenza virus, a sort of obligate intracellular parasite, must coopt a myriad of host cell proteins and processes in order to complete its lifecycle, and produce infectious progeny virions in hopes of spreading to and infecting new cells …
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Broad-spectrum antivirals against coronavirus using natural products and drug repurposing strategies
… toolkit: natural product-based discovery and host-targeted drug repurposing. Chapter three investigates natural product-based antiviral discovery, with a focus on Nigella sativa (black seed) oils. While direct contact assays revealed limited antiviral efficacy, vapour-phase diffusion of the …
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Systems analysis and characterization of mucosal immunity
During acute and chronic infectious diseases hosts develop complex immune responses to cope with bacterial persistence. Depending on a variety of host and microbe factors, outcomes range from peaceful co-existence to detrimental disease. Mechanisms underlying immunity to bacterial stimuli span …
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Protein Folding, Host Cell Proteostasis, and Viral Evolution
… virtually all RNA viruses rely on their host’s proteostasis network components for viral protein folding. It follows that the host’s proteostasis network could play a prominent role in defining the sequence space accessible to an evolving viral protein. In this thesis, I address how host …
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Deciphering the molecular basis of the global emergence of non-tuberculous Mycobacteria as important human respiratory pathogens
… It is known that the bacteria manipulate the host immune response to their advantage; however, the intracellular trafficking and survival strategies are poorly understood.<br/><br/>To address this, we have developed an image-based, single cell assay using a fluorescence dilution (FD) system to …
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Characterization of the antiviral activity of cyclosporine A against dengue virus
… cyclophilin A or B, which are not required host factors for DENV-2 in Huh7 and A549 cells. In Huh7 and A549 cells, CsA induces interferon regulatory factor-1 (IRF1)-dependent antiviral gene expression. While CsA does not increase IRF1 levels in Huh7 cells, it enhances IRF1 protein levels in …