Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Host-pathogen interface"”.
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Evolution of targets at the host-pathogen interface
… and therapeutic options for both the bacterial pathogen Mycobacterium tuberculosis (Mtb) and betacoronaviruses – the Severe Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) in particular – is presented. Chapter 2: Protein-coding potential of the Mtb genome <br>Using comparative genomics, I …
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Chemical Reporters for Investigating Lipidated Proteins at the Host-Pathogen Interface
… such, defects in protein lipidation can render host cells more susceptible to microbial infection and are also associated with a variety of human diseases ranging from cancer to neurological disorders. Moreover, viral and bacterial pathogens can exploit and modulate the host lipidation machinery …
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Identification and characterization of rickettsial proteins at the host-pathogen interface
Bacterial pathogens subvert host cell processes during infection by secreting protein effectors that manipulate host machinery. Cataloging such effectors has enabled a deeper exploration of the molecular basis of disease for numerous pathogens. Members of the Rickettsia genus are obligate …
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Evolution of vesicular transport in kinetoplastids: dynamics and novel gene products
… from their site of uptake or synthesis. For many pathogens the trafficking system has a special relevance as it is responsible for maintaining the host-pathogen interface, i.e., the cell surface. Both the surface and the underlying trafficking apparatus are intimately connected with immune evasion …
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Immunocytochemical studies of fungal cell surface molecules and the vicia faba-Botrytis interaction
… and infection hyphae and pervaded the degraded host cell walls. Double-labelling methods using BC- KH4 and specific markers for plant wall components allowed the host-pathogen interface to be investigated further. Interactions between fibrillar matrices and host walls and/or cytoplasm were …
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Surface Coat Replacement Dynamics and Antigen Glycosylation in T. Brucei Influence Evasion of the Host Antibody Response
… of human and animal trypanosomiasis, evades host immunity through antigenic variation of its variant surface glycoprotein (VSG) coat. During infection, the VSG coat elicits a robust antibody response, but the parasite escapes antibody-mediated clearance by repeatedly accessing its large …
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Investigation of the interactions between Trypanosoma congolense invariant surface glycoproteins and components of the mammalian immune system
African trypanosomes are single-celled eukaryotic pathogens of humans and animals. As they are extracellular in vertebrate hosts, their cell surface forms the primary host-pathogen interface. Invariant surface glycoproteins (ISGs) are a large family of cell surface proteins with recent expansion …
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Interferon-Inducible GTPases as Positive and Negative Regulators of Inflammasomes
… system is able to detect and respond to invading pathogens. PRRs bind conserved microbial components and subsequently initiate pro-inflammatory defense programs. While effective at eliminating pathogens, these inflammatory responses can have deleterious effects; excessive inflammation can result …