Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Host-microbial interactions"”.
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Host-Microbial Interactions that Modulate Luminal IgA
… role at a critical intersection between the host immune system and the microbiota. In the work detailed here, I sought to investigate IgA delivery and stability using in vitro and in vivo methods. First, I developed a primary intestinal epithelial monolayer system, and utilized this system to …
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Bioinstrumentation and Statistical Methods for Investigating Host-Microbial Interactions
Metabolic interactions between hosts and their associated microbiota, the latter referred to as the microbiome, contribute to the host phenotype and nutrient cycling within the ecosystem. There is broad diversity in the type and complexity of interactions for a given host and environment. …
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Investigation of mechanisms underpinning host-microbial interactions in the gastrointestinal tract
… have identified different members of a host’s microbiota, particularly bacteria, as having critical roles in shaping the development and function of both intestinal and extra-intestinal immunity as reviewed in the introductory chapter (Chapter I) to this thesis. However in comparison to …
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Sources of Variation in the Microbiome of Pre-Weaned Dairy Calves
This study investigated the microbial colonization and maternal influences on the neonatal calf gut microbiome. Microbiome samples were collected from dams (n = 6) and calves (n = 6) using sterile flocked swabs. The vaginal, oral, and fecal bacterial communities were examined from the dam and the …
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The Role of Fusobacterium nucleatum in the Tumor Microenvironment
… colonize tumors, how they survive inside host cells, how they modulate host cell phenotypes, and if their elimination should complement cancer therapy. This is, in part, due to the lack of representative animal models, challenges in co-culture of host epithelial cells and bacteria, and …
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Poxvirus A51R Proteins Directly Bind to Microtubules to Antagonize Microtubule Dynamics, Intracellular Transport, and a Cell-intrinsic Antiviral Response
… network to facilitate their replication inside host cells. Poxvirus A51R proteins have been shown to colocalize with, and bundle, MTs, but the mechanisms of their MT interactions remained unclear. Additionally, vaccinia virus (VV), a model poxvirus, utilizes kinesin motor proteins on MTs to …
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Effects of diet and loss of ovarian hormone production on adiposity, inflammation, cecal integrity, and gut microbial communities of rodent models
… The objective of aim 3 was to examine the cecal microbial communities and barrier function in OVX or SHM mice fed a HFD or LFD for 12 wk. OVX/HFD mice had greater (p<0.05) serum lipopolysaccharide-binding protein than OVX/LFD mice. Cecal expression of inflammatory genes was not elevated due to …