Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 58 for “"Host-Microbe"”.
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Host-microbe interactions in the inflamed gut
… to the luminal microbiota in a susceptible host. We proposed that this may be caused either 1) by an abnormal microbial composition or 2) by weakening of the protective mucus layer due to excessive mucus degradation, which may lead to an easy access of luminal antigens to the host mucosa …
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Investigating the host-microbe dialogue in aging
… on key inter-kingdom signalling molecules, host produced but bacterially modified Bile acids (BAs) and on dietary microbially derived Fatty acids (FAs) as key elements to indicate gut microbial potential impactful roles. In the context of Chapter 3, this thesis examined the levels of BAs and …
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Geographic and Host-Microbe Symbiotic Influence on Secondary Metabolism
… to the Arctic region and the importance of host-microbe interactions in natural product discovery. Bioactive metabolites have been reported from a myriad of marine and terrestrial organisms around the world including plants, insects, sponges, tunicates, bacteria, and fungi among others. Many …
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Studies of the host-microbe relationship in aquaculture-raised animals
… inhabiting the various niches of a given host comprise its microbiome and provide several key health benefits. The microbiome impacts nutrient acquisition, gut homeostasis, protection against pathogens, and immune system modulation. Therefore, much attention has been placed on studying how …
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The relevance of bacterial isoprenoid biosynthetic pathways for host-microbe interactions
… 2-C-methyl-D-erythritol 4-phosphate (MEP)) for host-microbe interactions. We determined a significant reduction in microbial diversity in the murine gut microbiota (by next generation sequencing) following oral administration of a common anti-cholesterol drug Rosuvastatin (RSV) that targets …
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The impact of host-microbe interactions on murine colonic secretomotor function
… this regard, I examined the impact of commensal host-microbe interactions on colonic secretomotor function in mouse. I first examined the influence of two different probiotic (microorganisms which, when given in adequate amounts, can confer health benefits upon the host) strains, Bifidobacterium …
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Computational Tools and Resources for Pan-Cancer Analyses of Host-Microbe Interactions
… integrated ecosystem that interacts with the host to influence cancer development and progression, as well as affect response to anti-cancer therapies, suggesting opportunities for diagnostic and therapeutic approaches. Many microbe-microbe and host-microbe interactions relevant to cancer are …
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Candida Albicans Als5p Amyloid In Host-Microbe Interactions: A Ceanorhabditis Elegans Study
… adherence[2]. We evaluated the role of Als5p in host-microbe interactions, using Caenorhabditis elegans as a host model and feeding them Saccharomyces cerevisiae expressing Als5p on the surface. Als5p-expressing yeast had increased intestinal accumulation rates when compared to non-expressing S. …
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Constraint-based modeling of host-microbe and microbe-microbe metabolic interactions in the human gut
… gut microbiota performs essential functions for host health and wellbeing. Disruption, or dysbiosis, in gut microbiota composition has been directly linked to the pathogenesis of complex diseases. Understanding the mechanisms behind these links between microbiota and host health and disease …
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Development of Novel Methods to Study Host-Microbe Interactions In The Larval Zebrafish Gastrointestinal Tract
… new tools with potential applications in host-microbe interactions and barrier dysfunction diseases.</p>
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Multi-Scale Modelling of Host-Microbe Interactions: From Cell Membranes to Multi-Cellular Gut Models
… multi-cell type approaches, to address three microbe-related applications. Different electrochemical devices are used to monitor each for applications in host-pathogen interaction, microbiome differences in irritable bowel syndrome and microbe metabolite effects. To this end, cell membrane …
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Harnessing Systems Bioengineering Approaches to Study Microbe-Microbe and Host-Microbe Interactions in Health and Disease
… of the microenvironment in driving the microbe-microbe and host-microbe interactions, respectively. Herein, the first part of the dissertation includes designing and engineering a synthetic E. coli killer-prey microecological system where we quantified the quorum-sensing mediated …
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Host-Microbe Relations: A Phylogenomics-Driven Bioinformatic Approach to the Characterization of Microbial DNA from Heterogeneous Sequence Data
… and always complex associations with microbes. Therefore, it should come as no surprise that when the genome of a eukaryote is sequenced, a medley of bacterial sequences are produced as well. These sequences can be highly informative about the interactions between the eukaryote and its …
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Assessment of an ex vivo porcine lung model to investigate host-microbe interactions in cases of ventilator associated pneumonia
… to viable tissue highlighting the hots-microbe interactions, to establish a routine method of taking a BAL sample from the porcine lungs to therefore identify the normal microbial constituents within the porcine lungs, to establish the cell structures communally present within the lung …
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Impact of Brewing Industry Byproducts Used as Feed Additives for Aquaculture-Raised Fish: Studies of the Host-Microbe Relationship
… via alternate prophylactic measures to increase host health is an essential area of research; modulation of the host intestinal bacterial community via prebiotics is one possibility. Prebiotics refer to non-digestible food ingredients that are thought to stimulate the growth of beneficial …
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Gut physiology and host-microbe interactions of the rotation-resistant variant of the western corn rootworm (Diabrotica virgifera virgifera LeConte) (Coleoptera: Chrysomelidae)
… root tissues for the larvae. Close access to the host plant is generally secured by strong adult ovipositional fidelity to cornfields. Annual crop rotation between corn and soybean (Glycine max) has been the main strategy for controlling the WCR in the eastern Corn Belt; WCR larvae emerging in …
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Saproxylic Insights: Unveiling Gut Microbial Dynamics in Forest Floor Invertebrates and Their Frass in the Tallaganda Region, NSW
Host-microbe associations have been, and continue to be, an area of great interest. Even within a well-defined and well-studied gut microbial community, little attention has been paid to how the dynamics of the host's gut environment may undergo shifts, potentially exhibiting concurrent variations …
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Bacterial Mucolysis, Inflammatory Mucogenesis and the Stability of Host-Intestinal Microbiota Interactions
… between the intestinal microbial ecology and the host. Moreover, the intestinal mucosal barrier serves as an important and necessary mediator of host-microbe interactions. Due to the exquisite sensitivity of this complex system, disruptions to the microbiota, the mucosal barrier or the …
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Signatures of gut microbes in human diseases
… community of microorganisms. Through evolution, host-microbe interactions have been shaped toward mutually beneficial relationships that support host health. Consequently, perturbations of the microbial compartment are increasingly recognized as contributing factors in a wide range of human …
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The influence of mucins on bacterial communities
… epithelia in the body. By supporting commensal microbes and preventing pathogenic invasion, mucus maintains host-microbe homeostasis. Mucin polymers, the primary gel-forming component of mucus, are an important mediator of mucus-microbe interactions. In this thesis, I demonstrate that mucins …
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