Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 40 for “"Host microbe interactions"”.
-
Host-microbe interactions in the inflamed gut
… to the luminal microbiota in a susceptible host. We proposed that this may be caused either 1) by an abnormal microbial composition or 2) by weakening of the protective mucus layer due to excessive mucus degradation, which may lead to an easy access of luminal antigens to the host mucosa …
-
The relevance of bacterial isoprenoid biosynthetic pathways for host-microbe interactions
… 2-C-methyl-D-erythritol 4-phosphate (MEP)) for host-microbe interactions. We determined a significant reduction in microbial diversity in the murine gut microbiota (by next generation sequencing) following oral administration of a common anti-cholesterol drug Rosuvastatin (RSV) that targets …
-
The impact of host-microbe interactions on murine colonic secretomotor function
… this regard, I examined the impact of commensal host-microbe interactions on colonic secretomotor function in mouse. I first examined the influence of two different probiotic (microorganisms which, when given in adequate amounts, can confer health benefits upon the host) strains, Bifidobacterium …
-
Computational Tools and Resources for Pan-Cancer Analyses of Host-Microbe Interactions
… integrated ecosystem that interacts with the host to influence cancer development and progression, as well as affect response to anti-cancer therapies, suggesting opportunities for diagnostic and therapeutic approaches. Many microbe-microbe and host-microbe interactions relevant to cancer are …
-
Candida Albicans Als5p Amyloid In Host-Microbe Interactions: A Ceanorhabditis Elegans Study
… substrates, and is upregulated during commensal interactions, but is downregulated during active C. albicans infections[1]. An amyloid forming core sequence at residues 325-331 has been shown to be important for Als5p function, because a single amino acid substitution at position 326 (V326N) …
-
Development of Novel Methods to Study Host-Microbe Interactions In The Larval Zebrafish Gastrointestinal Tract
… new tools with potential applications in host-microbe interactions and barrier dysfunction diseases.</p>
-
Multi-Scale Modelling of Host-Microbe Interactions: From Cell Membranes to Multi-Cellular Gut Models
… and disease including microbiome-gut-immune interactions. Recently, there has been much progress in the development of in vitro intestinal models with studies incorporating mechanical and biophysical cues, immune cells and supporting longer-term co-culture of microbiota, amongst others. …
-
Harnessing Systems Bioengineering Approaches to Study Microbe-Microbe and Host-Microbe Interactions in Health and Disease
… of the microenvironment in driving the microbe-microbe and host-microbe interactions, respectively. Herein, the first part of the dissertation includes designing and engineering a synthetic E. coli killer-prey microecological system where we quantified the quorum-sensing mediated …
-
Assessment of an ex vivo porcine lung model to investigate host-microbe interactions in cases of ventilator associated pneumonia
… to viable tissue highlighting the hots-microbe interactions, to establish a routine method of taking a BAL sample from the porcine lungs to therefore identify the normal microbial constituents within the porcine lungs, to establish the cell structures communally present within the lung …
-
Gut physiology and host-microbe interactions of the rotation-resistant variant of the western corn rootworm (Diabrotica virgifera virgifera LeConte) (Coleoptera: Chrysomelidae)
… root tissues for the larvae. Close access to the host plant is generally secured by strong adult ovipositional fidelity to cornfields. Annual crop rotation between corn and soybean (Glycine max) has been the main strategy for controlling the WCR in the eastern Corn Belt; WCR larvae emerging in …
-
Bacterial Mucolysis, Inflammatory Mucogenesis and the Stability of Host-Intestinal Microbiota Interactions
… between the intestinal microbial ecology and the host. Moreover, the intestinal mucosal barrier serves as an important and necessary mediator of host-microbe interactions. Due to the exquisite sensitivity of this complex system, disruptions to the microbiota, the mucosal barrier or the …
-
Signatures of gut microbes in human diseases
… community of microorganisms. Through evolution, host-microbe interactions have been shaped toward mutually beneficial relationships that support host health. Consequently, perturbations of the microbial compartment are increasingly recognized as contributing factors in a wide range of human …
-
Molecular Phylogenetic Analysis of Novel Spiroplasma Isolates
… bacteria that have evolved to occupy broad host ranges including plants, insects and crustaceans. Spiroplasmas are the causative agent of several economically important agricultural diseases, but most host-microbe interactions appear to be commensal. Given the ubiquitous nature of these …
-
Function and Environmental Regulation ofkpsF, the First Gene of the Region One Operon of Escherichia Coli K1
… that may be of general importance in diverse host-microbe interactions.
-
Proinflammatory cytokines as mediators of phenotypic change in bacteria implicated in ventilator-associated pneumonia
… We hypothesise that greater understanding of host-microbe interactions (HMI) in the pathogenesis of VAP should dictate appropriate treatment. This thesis begins to address this by investigating the role of host immunity on bacterial physiology.We measured the effects of proinflammatory …
-
Exploiting Ruminococcus gnavus and Limosilactobacillus reuteri to strengthen host immunity and treat infections
… millions of years of coevolution between the host and intestinal microbiota have fostered a predominantly symbiotic relationship, the intestinal epithelium is tasked with balancing immune tolerance and anti-pathogen immunity. One way in which the mucosal epithelium maintains healthy …
-
Beneficial Fungal Secretome and Synthetic Consortia to Improve Soybean Growth During Drought Stress
… and root exudate analyses to define host–microbe interactions and improve FunSynCom composition in longer, nutrient-limited assays to refine community design.
-
THE EVOLUTIONARY ECOLOGY OF HOST-MICROBIOME SYMBIOSIS IN ONTHOPHAGUS DUNG BEETLES
The effect of host-microbe interactions on diverse aspects of host biology are increasingly appreciated across biological disciplines, yet the roles played by these interactions in shaping host evolution remain poorly understood. My dissertation research seeks to address these and related issues …
-
The impact of microgravity conditions on human gut microbiome
… on intestinal physiology and microbial interactions remain largely unexplored. This PhD thesis investigates the impact of microgravity on the human gut microbiome through in vitro experiments, focusing on the intestinal epithelial barrier as a key interface between host and microbes. A …
-
Genetic analysis of p38 mitogen-activated protein kinase signaling in innate immunity and stress physiology of Caenorhabditis elegans
Host-microbe interactions play an important role in the physiology and evolution of animals. Interactions with microbes can generally be considered beneficial or pathogenic to the host. The ability of an organism to mount an immune response to infection by pathogenic microbes is critical to its …
Page 1 of 2