Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 119 for “"Host immune response"”.
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Substance P And The Host Immune Response
… examined the mechanism by which SP regulates host immunity, specifically, its control of growth factors and TLR expression in the P. aeruginosa-infected cornea. The role of mTOR and VIP in corneal infection and inflammation also was tested.</p> <p>SP has a dual role in bacterial infection, …
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Structural Investigation of Bacterial Pathogenesis and Host Immune Response
… utilize various mechanisms to invade the host and cause a variety of diseases in human, animals, and plants. Ongoing research is focused on revealing how several essential proteins manipulate the host immunity to cause disease. It’s necessary to understand the host-bacterial interactions …
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Mycobacterial strain diversity : impact on the host immune response
Bibliography: p. 169-207.
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Dissecting the impact of macrophage migration inhibitory factor (MIF) on host immune response
… implicated in mediating both innate and adaptive immune responses in inflammatory and infectious diseases. The sequence and structure of MIF is highly conserved across the avian phylogeny, which underlies high sequence homology and functional similarities between turkey and chicken MIFs. Turkey …
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The role of TNFRp55 and TNFRp75 in the host immune response to Mycobacterium tuberculosis
… necrosis factor alpha (TNFα) is critical for host protective immunity against Mycobacterium tuberculosis infection. TNFRp55 and TNFRp75 can both bind TNFα and conduct signaling, however the respective roles, in particular that of TNFRp75 in an M. tuberculosis aerosol inhalation infection was …
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Using the host immune response to hemorrhagic fever Viruses to understand pathogenesis and improve diagnostics
… severe infections characterized by a hyperactive immune response that often leads to multiorgan failure and death. Current diagnostic tests are based on detecting viral proteins and nucleic acids in the blood. These are late-stage events during infection, which makes it impossible to perform a …
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Early Events Following Oral Transmission of Simian Immunodeficiency Virus: From Viral Entry to Host Immune Response
… indicates a major obstacle for a vaccine recall immune response to eliminate infected cells prior to dissemination. Analyses of immunologic events through the assessment of mucosal innate immune gene expression, as well as the initiation of the adaptive immune response, were undertaken in a …
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The role of mosquito saliva on host immune response and pathogenesis of West Nile virus\r\n
… infected when an infectious mosquito pierces the host epidermis to take a blood meal, depositing virus principally in the extravascular tissue. Accumulating evidence has demonstrated that the mosquito saliva, which carries WNV into the vertebrate, is not simply a transport medium, but can have a …
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Porcine circovirus associated disease: Modulation of the host immune response to PCV2 and PRRSV by regulatory T cells
… clinical disease are not fully understood, but immune modulation by the co-infecting viruses is thought to play a critical role. The ability of dendritic cells (DC) infected with PRRSV, PCV2 or both to induce regulatory T cells (Tregs) was evaluated in vitro. DCs infected with PCV2 significantly …
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Potential Roles of Peroxidases In Caenorhabditis Elegans Innate Immunity
… production of ROS (reactive oxygen species) in response to pathogen detection is a rapid, nonspecific response that is evolutionarily conserved from nematodes to humans. ROS serve as direct and indirect effectors of innate and adaptive immunity. In <em>Caenorhabditis elegans</em>, a ROS burst is …
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Antibody Response to Lipopolysaccharide of Salmonella Typhimurium
… such as acetylation has a profound effect on the host immune response.
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Human Cytomegalovirus Us17 Locus Fine-Tunes Innate And Intrinsic Immune Responses
… strategies to combat, subvert, or co-opt host immunity. One evolutionary strategy for this involves "capture" of a host gene and then its successive duplication and divergence, forming a gene family, many of which have immunomodulatory activities. The HCMV US12 family consists of ten …
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Characterisation of the lipooligosaccharide biosynthesis gene cluster in campylobacter species
… to determine the role of LOS in mediating the host immune response. Analysis of the LOS locus gene content in 50 C. jejuni clinical isolates and 703 publicly available C. jejuni genome sequences revealed that the class B (Group 1) was the most abundant LOS locus class in C. jejuni. Two novel C. …
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Solution Structure and Characterization of Lipid Binding of the NOXO1β PX Domain
… monocytes. The PHOX enzyme plays a role in the host immune response through production of ROS. Deficiencies in components of the phagocytic NADPH oxidase lead to weakened host defense, as seen in chronic granulomatous disease. There are also non-phagocytic homologues of the phagocytic NADPH …
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Rodent inflammasome activation by Toxoplasma gondii
… for the transmission of the parasite between hosts. As the host immune response drives cyst formation, the establishment of this chronic infection relies on the parasite's ability to find a balance between activation of a host immune response and evasion of parasiticidal mechanisms. This …
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Cytokine and Chemokine Profiles in a Rat Model of Hemorrhagic Shock after Immuno-Modulation by Androstenetriol
… agent, Androstenetriol (AET), up regulates host immune response by modulating the continued expression of mediators, including cytokines. In a double-blinded experiment, rats were hemorrhaged, driven by volume or pressure conditions, then resuscitated with fluids and packed red blood cells …
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Glycan Shielding of the Influenza Virus Hemagglutinin Elicits Evasion of the Adaptive Immune Response and T-Cell-Driven Pathology
… glycosylation sites to assess the impact on the host immune response. These studies show that mice infected with a glycosylated virus remain susceptible to challenge with a non-glycosylated virus, glycosylated viruses elicit an inferior immune response, and in this context T-cell pathology and …
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Importanza prognostica delle citochine e loro ruolo nell'immunomodulazione: risultati di studi sperimentali in vivo e in vitro
… produced by several cell types and secreted in response to various stimuli. These molecules are able to modify the behaviour of other cells inducing activities like growth, differentiation and apoptosis. In the last years, veterinary scientists have investigated the role played by these factors; …
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Characterisation and therapeutic modulation of toll-like receptor signalling in response to the intracellular pathogen F. tularensis
The induction of an innate immune response upon infection is dependent on the detection of the invading organism and the generation of a signalling cascade leading to the production of inflammatory mediators. Toll-like receptors are expressed on multiple cell types and induce the activation of a …
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Structure and Function of Bordetella Transcription Factor BpsR
… populations encapsulated in a self-produced or host-derived opaque matrix composed of polysaccharides, proteins, and extracellular DNA. They help bacteria persist, resist and evade host immune response. In Bordetella, the Bordetella polysaccharide (Bps) is a crucial polysaccharide component of a …
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