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Showing 1 to 11 of 11 for “"Host genetic factors"”.

  1. The influence of host genetic factors on the susceptibility to HIV and HCV infections among intravenous drug users

    Huik, Kristi2014

    tartu

  2. Pharmacogenomics and pharmacokinetics of antiretroviral drugs and their associations with metabolic complications in HIV-infected Black South Africans

    Sinxadi, Phumla ZDivision of Clinical Pharmacology2016

    … variability, which in part, may be explained by host genetic factors. Mitochondrial DNA (mtDNA) variation influences ART related metabolic complications. However, the associations between genetic polymorphisms and pharmacokinetics of antiretroviral drugs, and their associations with metabolic …

    cape-town Repository record

  3. Studies on multiply exposed but persistently HIV-1 seronegative sex workers from KwaZulu/Natal, South Africa

    Malaza, Abraham LuckyDivision of Medical Microbiology2002

    … aim of this study was to determine whether host genetic factors are associated with resistance to HIV-1 infection in a group of highly exposed persistently seronegative sex workers from KwaZulu/Natal, South Africa. A cohort of 17 African highly exposed but persistently seronegative (HEPS) …

    cape-town Repository record

  4. A genetic screen to identify novel Helicobacter pylori virulence factors using Saccharomyces cerevisiae as a model eukaryotic cell

    Bothwell, Amelia M.

    … severe gastric disease due to environmental factors, host genetic factors, and more significantly, genetic differences in the infecting H pylori strains. Type I strains of H pylori contain a 40-kb cytotoxin-associated pathogenicity island (cag PAl) that encodes and secretes the CagA protein …

    eastern-wash Repository record

  5. Association of Interleukin-12 gene polymorphism with Hepatitis B virus persistnece and Hepatocelluar carcinoma

    박, 진선2011

    … Natural course of HBV infection may result from host immune factors including single nucleotide polymorphisms(SNPs), and cytokines play a crucial role in host immune defense. This study was undertaken to investigate the association between HBV persistence and development of hepatocelluar …

    ajou Repository record

  6. The impact of EPHA2 polymorphism on KSHV infectivity and KS prevalence among HIV/AIDS patients in South Africa

    Blumenthal, Melissa Jayne WalcottDivision of Medical Biochemistry and Structural Biology2017

    … all AIDS patients develop KS, suggesting that host genetic factors contribute to susceptibility. The infection mechanism of KSHV in endothelial cells has recently been elucidated and highlights Eph Receptor A2 (EPHA2) as a specific host receptor for virus entry. Furthermore, EPHA2 has been …

    cape-town Repository record

  7. Genetic Control of Survival and Weight Loss during Pneumonic Burkholderia pseudomallei (Bp) Infection

    Emery, Felicia D.2016

    … disease. Furthermore, according the CDC, other factors including aerosol infectivity, the severity of infection, and the global distribution of this pathogen makes it a potential bioterrorism agent that poses a threat to national security, if intentionally released into populated areas.</p> …

    tenn-hsc Repository record

  8. Airway Epithelium Organotypic Culture Models as a Platform for Adverse Outcome Pathway Assessment of Engineered Nanomaterials

    Nicholas, Tyler2019

    … concern to public health. Interactions between host genetic and acquired factors, or gene à environment interactions (Gà E), may play a defining role in identifying sensitive populations to AgNP exposures in occupational settings. Host genetic factors, such as sex, genotype, or polymorphism, …

    washington Repository record

  9. Pharmacokinetic-Pharmacogenetic-and-Pharmacodynamic Adherence Relationships in Cohort South African HIV Infected Children on Lopinavir-and Nevirapine-Based Regimens

    Moholisa, Retsilisitsoe RDepartment of Medicine2019

    … part of this variability may be explained by host genetic factors. Associations between human genetic variants and exposure to lopinavir and nevirapine are incompletely understood, and have not been studied in a South African paediatric population. Data in this thesis were from a clinical …

    cape-town Repository record

  10. Frequency of CCR2V64I and CCR5Δ32 host genes and their association with HIV infection among pregnant women from Harare, Zimbabwe

    Soko, WhiteUniversity of the Western Cape2010

    Aim: To determine and compare the prevalence of CCR5-Δ32 and CCRV64I genes in HIV positive and HIV negative population of pregnant women from Harare, in Zimbabwe. Results: The proportion of pregnant women with the homozygous CCR2V64I gene was 24.38% and this gene was two times more associated with …

    western-cape Repository record

  11. Genetic Predictors of Clinical Outcomes In Non-Small Cell Lung Cancer Patients

    Pu, Xia2013

    … in the US. Emerging evidence has shown that host genetic factors can interact with environmental exposures to influence patient susceptibility to the diseases as well as clinical outcomes, such as survival and recurrence. We aimed to identify genetic prognostic markers for non-small cell lung …

    uthsc Repository record