Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"Host directed therapy"”.
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Investigation of the potential of Spleen Tyrosine Kinase (SYK) as a target for host-directed therapy during mycobacterial infection in macrophages
… therapeutics are therefore urgently needed. Host directed therapies (HDT) are currently a promising way forward for limiting tissue pathology caused by Mtb. Spleen tyrosine kinase (SYK) plays an important role in innate immune signalling. It is expressed on innate immune cells such as …
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Novel pathways of human host defence against Mycobacterium tuberculosis
… tuberculosis (TB). An improved understanding of host factors that affect Mtb clearance by macrophages, the most important cell for Mtb defence, has the potential to improve treatment regimens for TB. My thesis describes how virulent double auxotroph Mtb H37Rv is distinguished by a greater …
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The role and host-directed targeting of long non-coding RNAs in macrophage polarization during Mycobacterium tuberculosis infection
… Mycobacterium tuberculosis (Mtb), evades host immune responses by skewing macrophage polarization towards a less microbicidal alternative state to avoid classical effector killing functions. However, the molecular details underlying these evasion mechanisms remain incomplete and current …
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Mechanisms of Innate Immune Dysfunction During Mycobacterium tuberculosis and HIV Co-infection
… activation within macrophages, the cellular host of both Mtb and HIV, leads to a caspase-1 dependent increase in IL-1β secretion and cell death in vitro. To target the inflammasome pathway for host-directed therapy, the selective caspase-1 inhibitor, VX-765, was used. VX-765 treatment …
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Deciphering the molecular basis of the global emergence of non-tuberculous Mycobacteria as important human respiratory pathogens
… It is known that the bacteria manipulate the host immune response to their advantage; however, the intracellular trafficking and survival strategies are poorly understood.<br/><br/>To address this, we have developed an image-based, single cell assay using a fluorescence dilution (FD) system to …
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Functional miRNA-based Phenotypic Screening as a tool to delineate HIV-host interactions and facilitate Novel Drug Discovery
… 15 proteins HIV-1 is highly dependent upon its host's cellular machinery in order to complete its life cycle. Host-directed therapy thus represents a potentially lucrative strategy for the development of novel anti-HIV therapies. microRNAs (miRNAs) are short noncoding RNA molecules that function …
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Understanding host factors controlling intracellular killing of Mycobacterium tuberculosis
… of innate immunity is essential for a successful host response to infection with Mycobacterium tuberculosis (MTB) which causes human tuberculosis (TB). Better understanding of host factors controlling the survival of MTB within the macrophage (the primary site of MTB infection) may present …
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Investigation of minor groove binders (MGB), non-ionic surfactant vesicles (NIV) delivery systems and IL-4i1 as novel pathogen- and host-directed drug therapy for tuberculosis
… period of 6 months. The lack of efficient TB therapy and the emergence of MDR and XDR TB, there is an urgent need to find new drug targets for TB therapy through understanding the complex host-pathogen interactions. This may then lead to pathogen, host-directed therapies (HDT) or adjunct …
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The characterisation of dendritic cell, microglial, macrophage and T cell responses during mycobacterial infection of the central nervous system
… for the development of tuberculosis vaccines and host-directed therapy. This study provided new knowledge on immune mechanisms and pathogenesis experienced during TBM, thus adding to the current gap of advancing basic and translational TBM research that will inform clinical interventions. These …