Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 13 of 13 for “"Host defense peptides"”.
-
HOST DEFENSE PEPTIDES OF THE COAGULATION SYSTEM AND THEIR THERAPEUTIC POTENTIAL
… cascades. Emerging evidence suggests that host defense peptides (HDPs) may be potential lead structures in sepsis treatment due to their ability to modulate innate immune responses as well as being directly antimicrobial. From that perspective, this thesis aimed to identify and characterize …
-
Developmental gene expression of host defense peptides in immune organs and the small intestine of turkey poults (Meleagris gallopavo)
Host defense peptides (HDPs) are a large group of small positively charged peptides that play an important role in innate immunity. Their role is more critical at early ages when other components of the immune system have not fully developed. There are three classes of avian HDPs: avian beta …
-
Temporal and Tissue Specific Changes in Expression of Nutrient Transporters and Host Defense Peptides in Young Broilers during Salmonella and Campylobacter infections
… on mRNA abundance of nutrient transporters and host defense peptides (HDPs) during a Salmonella or a Campylobacter challenge in young commercial broilers. Comparisons were made between non-challenged and challenged (106, 107, or 108 colony forming units of Salmonella or Campylobacter) broilers …
-
Host modulation of excessive innate immune responses
… successful in eliminating danger, an excessive host-response can result in severe tissue injury. Factors that contribute to the elimination of the microbe are the same factors that cause tissue injury. Therefore, innate immune response has to be carefully balanced to avoid excessive inflammation …
-
Discovery and functional evaluation of a host defense peptide from Rana amurensis
… become a global medical problem, antimicrobial peptides (AMPs) are considered as a new possibility to replace traditional antibiotics. Host-defense peptides in amphibians skins with various biological activities are a rich source for discovering new AMPs. This thesis amid to discover and …
-
Antimicrobial Peptides Activity and Efficacy Prediction by Stochastic Models and Machine Learning Methods
… scientific attention is antimicrobial peptides (AMPs), also known as host defense peptides. In this work, we aim to facilitate the design of more effective peptides using computational tools by solving the following two main challenges in the field. First, the underlying microscopic …
-
On the discovery and biological characterization of porcine β-Defensin 5 (pBD-5)
… challenges humanity faces in the XXI century. Host defense peptides (HDPs), such as porcine β-defensins (pBDs), have gained attention for their immunomodulatory, microbiome-modulating, and antimicrobial properties. This thesis describes the discovery, synthesis, and biological characterization …
-
Cellular Events During Coccidial Infection in Chickens
… of cellular events was performed. Expression of host defense peptides (HDPs), apoptosis and autophagy related genes were examined in Eimeria challenged broilers. The results showed that upon Eimeria infection, LEAP2 was consistently downregulated in the target tissues, while the avian …
-
The Role of MRGPRX2/Mrgprb2 in Regulating Mast Cell Function
… multiple" amphipathic" ligands" including" neuropeptides," US" Food" and" Drug" Administration" (FDA)E approved"peptidergic"drugs"and"host"defense"peptides"such"as"LL_37."HDPs"also" known" as" antimicrobial" peptides" (AMPs)" have" been" investigated" in" depth" as" an" …
-
MRGPRX2 Signaling on Mast Cell-Mediated Pseudoallergy and Neuroimmune Interaction
… a diverse group of cationic agonists including host defense peptides, Food and Drug Administration (FDA)-approved drugs associated with pseudoallergy and neuropeptides secreted from sensory nerve endings. Not surprisingly, MRGPRX2 has been implicated in several MC-mediated health and disease, …
-
Host Defence Peptides (HDPs): investigating the structure-to-function relationship through bio-physical techniques
… antibiotics led a great attention on cationic host defense peptides (HDP) since their discovery in 1980s. The role of these molecules in the defense of organism against pathogens attack, together with their high selectivity for bacterial cells over the eukaryotic ones, made them attractive …
-
Exploration of innate immune response during infectious bovine digital dermatitis and the evaluation of topical therapeutic treatment
… progression and a novel description of bovine host defence peptides (HDPs) and their contribution to disease resolution are found herein. It was observed that active DD was characterized by necrotic tissue populated with neutrophils and elevated Cxcl-8 and Tlr4 expression. Tracheal …