Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 56 for “"Host defence"”.
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Midkine - a host defence protein
Every day we encounter many potentially harmful microbes in our environment. The epithelial linings constitute an anatomical barrier protecting us and they also produce antimicrobial polypeptides (AMPs) that act as a chemical barrier. These AMPs are small and positively charged, killing a broad …
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Novel pathways of human host defence against Mycobacterium tuberculosis
… tuberculosis (TB). An improved understanding of host factors that affect Mtb clearance by macrophages, the most important cell for Mtb defence, has the potential to improve treatment regimens for TB. My thesis describes how virulent double auxotroph Mtb H37Rv is distinguished by a greater …
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Targeting bacterial infections by using immunomodulatory host defence peptides and proteins
… Sepsis is caused by an uncontrolled systemic host response towards an invading pathogen. Due to the engagement of various systems including cellmediated responses, the coagulation and complement cascades, treatment of sepsis remains challenging. This is reflected in mortality rates of about 50 …
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Host-defence peptides from frog skin secretions: identification and bioactivity evaluation and optimisation
With the rapid development of antibiotic resistance, new types of antimicrobial drugs are urgently needed. A novel AMP, Brevinin-1H, was isolated from skin secretion of Amolops hainanensis (A. hainanensis) with broad spectrum antimicrobial activity, anti-proliferative activity, and strong …
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Protein FOG at the interface between G streptococci and human host defence lines
… and impetigo. In the immunocompromised host severe conditions, such as sepsis and necrotising fasciitis, may develop. In this thesis the interactions between GGS and various parts of human defence lines are investigated. A novel M protein from GGS, denoted FOG, was isolated, …
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Host Defence Peptides (HDPs): investigating the structure-to-function relationship through bio-physical techniques
… antibiotics led a great attention on cationic host defense peptides (HDP) since their discovery in 1980s. The role of these molecules in the defense of organism against pathogens attack, together with their high selectivity for bacterial cells over the eukaryotic ones, made them attractive …
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Impact of cationic host defence peptide LL-37 on human neutrophil death and inflammatory responses
Cathelicidins are cationic host defence peptides (CHDP) with essential roles in the innate defence system. These peptides have antimicrobial potential and the capacity to modulate innate immunity and inflammatory processes. Neutrophils (PMN) are the main reservoir of cathelicidins and play key …
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Investigating Pulmonary Immune Responses that Detect and Counteract Gram-negative Bacterial Infections
… the bloodstream, an immune paradox occurs where host responses counteract the invading pathogen but also contribute to devastating organ damage and death. During E. coli bacteremia, we observed in vivo pulmonary neutrophil and platelet interactions that resulted in immunothrombosis. Intravital …
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Exploration of innate immune response during infectious bovine digital dermatitis and the evaluation of topical therapeutic treatment
… progression and a novel description of bovine host defence peptides (HDPs) and their contribution to disease resolution are found herein. It was observed that active DD was characterized by necrotic tissue populated with neutrophils and elevated Cxcl-8 and Tlr4 expression. Tracheal …
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Cigarette smoke and human pulmonary immune responses to mycobacteria
… that form part of the innate immune system of host defence in the lung. The experiments on the pulmonary effects of cigarette smoke confirm that exposure has a significant effect upon innate host defences. Significant reductions in the production of key cytokines implicated in defences against …
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The bovine teat canal: Its role in pathogen recognition and defence of the mammary gland
… functionality that contributes significantly to host defence. The presence of innate immune components within the teat end tissues has been only very superficially described to date. The presence of antimicrobial activity in the protein fraction of the teat canal lining has been previously …
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Effects of temperature on wheat-pathogen interactions
… is often reported, effect of the environment on host defence is not. Many wheat resistance genes are temperature sensitive and these were used as a starting point to investigate defence temperature sensitivity in wheat starting with yellow rust resistance gene Yr36, previously shown to be …
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LL-37 and citrullinated LL-37: differential modulation of the oxylipin - chemokine axis
Inflammation plays a crucial role in the host immune system, and it involves a complex network of cellular and molecular events. In the lungs, human bronchial epithelial cells release cytokines/chemokines, and other mediators such as bioactive lipids and cationic host defence peptides (CHDPs) to …
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Investigating the variation in susceptibility between Arabidopsis thaliana ecotypes in response to Botrytis cinerea infection
… organism for studying the molecular basis of the host defence response to pathogen attack. One reason for this is the phenotypic variation in resistance found across the many Arabidopsis ecotypes, which provides researchers with a rich resource to dissect the molecular basis of resistance (or …
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Streptococcus pyogenes - a manipulator of human defences
… strategies for evading or manipulating the host defence systems to promote its own survival. A major virulence determinant of S. pyogenes is the cell surface attached M protein. It has previously been shown that M proteins of certain serotypes form complexes with fibrinogen and that these …
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NGC-HLB, a novel antimicrobial peptide from the skin secretion of Hylarana latouchii
… are considered to play a significant role in the host defence mechanisms against bacterial infection. In this study, the identification and antimicrobial activity of a novel peptide named NGC-HLB (GLLSGILGAGKKIVCGLSGLC), is described. The peptide consists of 21 amino acid residues and was …
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Identification and functional evaluation of a bioactive peptide QUB-1369 Secreted from the skin of The Common Frog (Rana Temporaria)
Antimicrobial peptides (AMPs) are host defence peptides found abundantly in amphibian skin secretions. They have broad antimicrobial spectrum of Gram-positive bacteria, Gram-negative bacteria, fungi and viruses. In this study, skin secretion of the common frog, Rana temporaria, was used to build a …
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Development of Novel Macrophage Imaging Agents
… are an important class of cell involved in host defence and homeostasis that are able to alter their phenotype in response to their surroundings and affect a wide range of biological processes. These properties make them critical to host function in normal and disease settings, leading to …
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Exploring the Pharmacological Potential of Bioactive Peptides in Amphibians and Plants: from Identification to Rational Design
… from other TCMs.<br/><br/>It is noteworthy that host-defence peptides have evolved as highly potent alternatives to antibiotics, exerting powerful physiological effects and high susceptibility of multidrug-resistant strains. However, some intrinsic weaknesses limit the direct usage of naturally …
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