Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"Host Genetics"”.
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Effect of viral and host genetics on pcv2 replication in lymphoblasts and clearance by monocytes
… wasting syndrome (PMWS). PMWS severity varies by host breed; notably, Landrace and Large White pigs exhibit more severe clinical manifestations than Piétrain pigs. Pathologic features of PMWS in wasted pigs include elevated viral loads, progressive lymphocyte depletion, and monocyte infiltration …
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The Influence Of Host Genetics And Different <i>Mycobacterium tuberculosis</i> Strains On Macrophage Functions And Clinical Outcome Of Tuberculosis Disease
… and clinical outcomes. Many studies have shown host and bacterial genetics are important factors in TB susceptibility and progression. I hypothesized that an impairment of macrophage phagocytic function, under the influence of genetic factors, may help explain the pathogenesis of the transition …
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Role of antiretroviral therapy exposure host genetics on cytomegalovirus infection status and association with gut microbiome profiles among pregnant black African women
… to CMV are not well studied. CMV has a wide host cell tropism that includes gut epithelial cells. CMV infection in the gut epithelial cells results in a leaky gut and potential gut microbial dysbiosis. In this study, we set out to determine the prevalence of CMV infection as well as factors …
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Long-term dynamics and theoretical considerations in coral holobiont adaptation
… two ways: through the nuclear evolution of the host and/or through acquiring new, more suitable symbiotic partners. Given the rapid rate of climate change, considerable attention has focused on the latter, as new symbiotic partnerships could, in theory, be formed within one coral generation. …
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COMBINATORIAL EFFECTS OF DIET-MICROBIOTA INTERACTIONS ON HOST METABOLISM
… influenced by complex interactions between diet, host genetics, the gut microbiota, and interorgan communication. Here, we describe findings from three studies that collectively elucidate novel mechanisms by which diet-microbiota interactions shape host metabolism, diet-host genetics shape …
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Investigating the role of host genetic polymorphisms in periodontitis susceptibility in a Western Cape population
… biofilm is key to the disease onset, the host’s immune-inflammatory response primarily drives tissue destruction. Periodontitis results from complex interactions between the oral microbiome, the host immune system, and environmental factors in susceptible individuals. The disease …
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The impact of variation in the Toll-like receptor 3 gene on epizootic hemorrhagic disease in Illinois white-tailed deer (Odocoileus virginianus)
… may provide additional insights into the role of host genetics on outbreaks of EHD in deer, which may allow wildlife agencies to better predict the severity of outbreaks.
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Statistical physics of T cell receptor development and antigen specificity
… model is also used to discuss one way in which host genetics can influence the selection of T cells and concomitantly the control of HIV infection. A model of the T cell selection process as diffusion in a random field of immobile traps that intermittently turn "on" and "off" is developed to …
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Identification of Host and Parasite Factors Mediating the Pathogenesis of Severe and Cerebral Malaria
… and outcome of severe malaria is determined by host-pathogen interactions, a complex interface of genetics and immune responses. Hypothetically, a spectrum of genetic susceptibility and resistance to severe disease exists within the host population, and malaria infection results in diverse host …
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HONEY BEES, BIODIVERSITY AND CLIMATE CHANGE
… The third study explores the influence of host genetics on gut microbiota composition. Although time of sampling was the predominant factor shaping microbiota structure (β-diversity), differences in microbial richness (α-diversity) among genetic lines were significant. One particular line …
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Effects Of Diet And Parasites On The Gut Microbiota Of Diverse Sub-Saharan Africans
… with subsistence strategy, sex, geography, and host genetics. I demonstrated that the degree of industrialization in these populations correlated with enrichment of functional pathways involved in the metabolism of xenobiotics and industrial pollutants. Moreover, I found that the gut microbiome …
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Detection and characterisation of enteroviruses and the gut virome in islet autoimmunity and type 1 diabetes using novel molecular methods
… T1D results from a complex interplay between host genetics and environmental factors, with virus infections, especially enteroviruses (EV) identified as a prominent candidate factor. Advances in molecular techniques including next generation sequencing (NGS) have enabled sensitive and …
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Elucidating the role of peptidoglycan from Borrelia burgdorferi in Lyme disease pathogenesis
… types of mice, suggesting the involvement of host genetics. Serum collected weekly throughout this experiment showed over a log fold change in the abundance of ALT and AST levels, which indicates liver dysfunction. Proteomic analysis of the livers of mice post pBb PG injection showed altered …
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Genetic diversity and population structure within Botswana: association with HIV-1 infection
… is attributable to, among other factors, host genetic variation. Characterisation of human genetic variations can contribute towards understanding the genetic aetiology of HIV-1 and foster development of novel preventive and treatment strategies against HIV-1. Despite the high burden of …
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Deciphering the relationship among nutrition, host and microbe
… These organisms have a profound impact on host physiology, particularly the immune system. Upon birth, the gut microbiota begins to take shape with input from various influences including genetics and environmental factors such as dietary habits, antibiotic use, and stress. While the gut …
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Gut microbiota-mediated bile acid metabolism: implications for oral drug absorption
… it has been elucidated that, in addition to host genetics, the gut microbiome must be considered as a source of pharmacokinetic variability. As newly emerging drug candidates trend toward low solubility and/or permeability, biopharmaceutical properties that prolong gastrointestinal residence …
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Pharmacogenomics and pharmacokinetics of dolutegravir and tenofovir in Southern Africans living with HIV
… or the interindividual differences in host response may, in part, be explained by host genetics. We characterized associations between genetic polymorphisms and dolutegravir exposure, tenofovir clearance and magnitude of weight gain in Southern Africans initiating ART. Methods We …
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Impact of Brewing Industry Byproducts Used as Feed Additives for Aquaculture-Raised Fish: Studies of the Host-Microbe Relationship
… via alternate prophylactic measures to increase host health is an essential area of research; modulation of the host intestinal bacterial community via prebiotics is one possibility. Prebiotics refer to non-digestible food ingredients that are thought to stimulate the growth of beneficial …
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Soil microbial community dynamics associated with agricultural crops
… interactions are polymodal and dependent on host genotype, soil chemical and physical properties and management practices. My final objective in this dissertation was to formally describe a fungal species, Penicillium acequia sp. nov. This fungal species was prevalent in agricultural soils …
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