Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Host Defence Peptides"”.
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Targeting bacterial infections by using immunomodulatory host defence peptides and proteins
… Sepsis is caused by an uncontrolled systemic host response towards an invading pathogen. Due to the engagement of various systems including cellmediated responses, the coagulation and complement cascades, treatment of sepsis remains challenging. This is reflected in mortality rates of about 50 …
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Host-defence peptides from frog skin secretions: identification and bioactivity evaluation and optimisation
… activity and haemolytic activity of peptides. The kink structure is important in antimicrobial activity against Gram-negative bacteria. A novel AMP, brevinin-1W peptide, was identified from skin secretion of Amolops wuyiensis (A. wuyiensis) with antimicrobial activity against …
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Host Defence Peptides (HDPs): investigating the structure-to-function relationship through bio-physical techniques
… antibiotics led a great attention on cationic host defense peptides (HDP) since their discovery in 1980s. The role of these molecules in the defense of organism against pathogens attack, together with their high selectivity for bacterial cells over the eukaryotic ones, made them attractive …
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Exploration of innate immune response during infectious bovine digital dermatitis and the evaluation of topical therapeutic treatment
… progression and a novel description of bovine host defence peptides (HDPs) and their contribution to disease resolution are found herein. It was observed that active DD was characterized by necrotic tissue populated with neutrophils and elevated Cxcl-8 and Tlr4 expression. Tracheal …
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Identification and functional evaluation of a bioactive peptide QUB-1369 Secreted from the skin of The Common Frog (Rana Temporaria)
Antimicrobial peptides (AMPs) are host defence peptides found abundantly in amphibian skin secretions. They have broad antimicrobial spectrum of Gram-positive bacteria, Gram-negative bacteria, fungi and viruses. In this study, skin secretion of the common frog, Rana temporaria, was used to build a …
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Exploring the Pharmacological Potential of Bioactive Peptides in Amphibians and Plants: from Identification to Rational Design
Bioactive peptides, which can be seen as a part of the innate immune response in most living things, are derived from bacteria, fungi, amphibians, insects, mammals, plants and many other sources. Here, Dermaseptin-PC (DM-PC) and PLX-PC, two novel AMPs (antimicrobial peptides), were discovered from …
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Epidermicin NI01 and human β-defensin 2 as modulators of macrophage subset responses
Antimicrobial peptides (AMPs) and host defence peptides (HDPs) have been extensively investigated for their antimicrobial activity and evidence suggests that they can also modulate the host immune system. However, little is known about their effects on macrophages, a key cell population in …
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Impact of cationic host defence peptide LL-37 on human neutrophil death and inflammatory responses
Cathelicidins are cationic host defence peptides (CHDP) with essential roles in the innate defence system. These peptides have antimicrobial potential and the capacity to modulate innate immunity and inflammatory processes. Neutrophils (PMN) are the main reservoir of cathelicidins and play key …
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LL-37 and citrullinated LL-37: differential modulation of the oxylipin - chemokine axis
Inflammation plays a crucial role in the host immune system, and it involves a complex network of cellular and molecular events. In the lungs, human bronchial epithelial cells release cytokines/chemokines, and other mediators such as bioactive lipids and cationic host defence peptides (CHDPs) to …