Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 17 of 17 for “"Hormonal Therapy"”.
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The Kras/Mapk Pathway and Ligand Independent Activation of Erα: Implications For The Treatment of Endometrial Cancer
<p>Hormonal therapy remains a first line option for the treatment of recurrent endometrial cancer (EC), however, many tumors demonstrate de novo or acquired resistance. Member kinases of the PI3K/AKT and Ras/MAPK pathways activate estrogen receptor α (ERα) independent of estrogen, however, few …
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Cytoplasmic Cyclin E Mediates Resistance to Aromatase Inhibitors In Breast Cancer
… tumors that express hormone receptors and need hormonal therapy. Aromatase inhibitors (AIs) block estrogen biosynthesis and are considered as the first line hormonal therapy for ER<sup>+ </sup>post-menopausal patients. However, resistance to these drugs remains a major challenge in clinic and …
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Menopause and cardiovascular, metabolic and bone parameters
… thesis investigates the effects of exercise, hormonal therapy (HT) and rosiglitazone on cardiovascular risk variables, glucose and insulin levels and bone turnover markers. It was hypothesised that these interventions would independentiy improve parameters measured, whilst combined treatment …
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Women's experiences of breast cancer and spiritual healing: a unitary appreciative inquiry.
… of women with breast cancer receiving long-term hormonal therapy. Background Spiritual Healing is widely available and used by many but is a neglected area of research. Whilst the exact mechanisms are not understood and healers make no claim to cure, evidence suggested that Spiritual Healing as a …
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The supramolecular derivatisation of pharmaceutically relevant compounds via co-crystallization and cyclodextrin inclusion complexation
… compounds, namely -estradiol (used for hormonal therapy and treatment of breast and prostate cancer), and progesterone (used for hormonal therapy), and (c) the potent antioxidant pterostilbene (displaying anti-cancer activity inter alia). Six new solid forms of the …
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Investigation of the anti-cancer effects of rosemary (Rosmarinus Officinalis L.) extract in human breast and prostate cancer cells
… is characterized by resistance to chemo and radiotherapy thus, finding new approaches to inhibit it are urgently needed. Similarly, prostate cancer is typically characterized by the expression of androgen receptor (AR) and prostate-specific antigen (PSA). Prostate cancer that is AR positive can be …
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Vitamin B6 Decreases Proliferation and DNA Synthesis in Human Mammary Carcinoma Cell Lines In Vitro
… by the action of the hormone estrogen. Hormonal therapy used to treat these estrogen-dependent breast cancers acts by interfering with the action of estrogen. Current treatments, such as tamoxifen, are not consistently useful due to development of resistance to these drugs. Tamoxifen …
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Biomarker-And Pathway-Informed Polygenic Risk Scores for Alzheimer's Disease and Related Disorders
… pathways have worse cognition following chemotherapy±hormonal therapy rather than hormonal-only therapy. In conclusion, PRSs based on biomarker- or pathway- specific genetic information may provide mechanistic insights beyond disease susceptibility, supporting development of precision medicine …
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Finding the Best Gene Candidate(s) as a Potential Therapeutic Target for N-MYC Overexpressing Neuroendocrine Prostate Cancer (NEPC)
… prostate cancer (NEPC). NEPC is resistant to hormonal therapy as cancer cells lack androgen receptors (AR) at this level, which results in rapid death (Huang et al., 2019). Due to the molecular structure of the N-MYC protein, N-MYC cannot be directly targeted as it lacks a binding pocket. …
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The Use of Catalytically Dead Cas9 to Identify Key Transcription Regulators in Triple Negative Breast Cancer
… receptor 2 make TNBC patients ineligible to hormonal therapy. For these reasons the identification of novel clinical targets still remains a priority. With the advances of multiomics, many of the genes transcriptionally upregulated in TNBC have been identified, but how they are disregulated …
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Meaning Making and Dispositional Mindfulness among Women with Breast Cancer
… who were receiving active treatment with chemotherapy and/or biologic therapy participated in the study and completed a Demographic questionnaire, the Intrusions subscale of the Impact of Event Scale-Revised (IES-R), the Religious Coping (RC) and Positive Reinterpretation (PR) subscales of the …
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The anti-cancer activity of a novel palladacycle, BTC2, in oestrogen receptor positive and triple negative breast cancers
… breast cancers are known to respond to hormonal therapy, drug resistance is a common occurrence. Furthermore, triple negative breast cancers lack a specific therapeutic target, which has led to poor treatment outcomes. Hence, there is a critical need for new therapeutic approaches. Our …
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Proteomic Investigation of Endocrine Therapy Resistance in Breast Cancer Investigating the Molecular Mechanisms for SERM Resistant Cell Lines Using SILAC-Based Proteomic Approach
… cause of cancer mortality in women worldwide. Hormonal therapy is considered one of the most effective therapies and is used against luminal-type malignancies. However, 40-50% of tumour cells can develop resistance, thereby limiting the success in breast cancer treatment. In this study, …
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The Encapsulation and Release of Flutamide Using Poly (ε-Caprolactone) Microspheres
… for prostate cancer include surgery, hormone therapy, radiation therapy and chemotherapy. These treatment methods are either very invasive or have harsh side effects including diarrhoea, nausea, alter liver function, anaemia and fatigue. A wide range of anti-cancer drugs in use today have very …
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Axillary web syndrome after treatment for breast cancer: An exploration of imaging evidence of fascial changes and its relationship to clinical variables
… conjunction with adjuvant therapies such as chemotherapy, radiotherapy and hormonal therapy, may alter patient healing patterns giving rise to complications such as axillary web syndrome (AWS). AWS presents as a puckering web of axillary skin overlying a cord of tissue that tightens with shoulder …
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Associations of sex, anthropometric and reproductive factors with clinicopathological and molecular characteristics of colorectal cancer
… this sex difference is not fully understood, but hormonal factors are suggested to play an important role. CRC is a largely heterogenous disease, and colorectal carcinogenesis can be regarded as a complex process involving multiple genetic and epigenetic alterations engendering tumours with …
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Predicting Adherence to Aromatase Inhibitor Therapy in Patients with Breast Cancer Using Protection Motivation Theory
… taking aromatase inhibitors as adjuvant therapy, were identified using a cancer registry managed by a University-based medical center. A survey instrument measuring patient’s medication taking behavior was developed using the Protection Motivation Theory, which was mailed to the patients. …