Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"Homomeric channel"”.
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The identification of novel cys-loop receptor genes in Dirofilaria immitis
… is emerging. Cys-loop ligand-gated ion channels are an untapped source for drug targets essential for nematode neurotransmission. This thesis presents the isolation and preliminary pharmacological characterization of three inhibitory D. immitis ion channels: GLC-2, GLC-4, and LGC-49. …
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Isolation and partial characterization of three members of the GGR-1 family in the parasitic nematode Haemonchus contortus
… anti-parasitic drugs. Cys-loop ligand gated ion channels have been recognized as important invertebrate specific drug targets. However, specific targets must be identified and characterized prior to drug development. This thesis describes the identification and partial characterization of three …
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Molecular characterization of GABA receptor subunits from the parasitic nematode Haemonchus contortus
… by several nematocides which target ion channels. We have identified two H. contortus ion channel genes, Hcounc- 49B and C that encode two GABA-gated chloride channel subunits. Electrophysiological analysis shows that the Hco-UNC-49B subunit forms a functional homomeric channel in Xenopus …
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Identification and characterization novel of cystine-loop ligand- gated chloride channels from Dirofilaria immitis: pharmacological analysis and novel compound screening
… an alarming rate. Cystine-loop ligand-gated ion channels are important receptors in nematode neurobiology, and as such are promising drug targets. The UNC-49 (GABA-gated chloride channel) and ACC (acetylcholine-gated chloride channel) family of receptors have been characterized as potential drug …
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Functional and Biochemical Characterization of KCNQ1/KCNE1 Subunit Interactions in the Cardiac IKs Potassium Channel
The IKs potassium channel, critical to control of heart electrical activity, requires assembly of pore-forming alpha subunits (KCNQ1) and accessory beta (KCNE1) subunits. IKs is the slowly activating component of delayed rectifier K+ current in the heart and is a major contributor to the timing of …