Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 308 for “"Homologues"”.
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Characterisation of the leukaemia-associated ETO homologues
… this thesis was to characterise ETO and its two homologues, myeloid translocation gene 16 (MTG16) and myeloid translocation gene related protein 1 (MTGR1), to elucidate their role in normal and disregulated hematopoiesis. We studied the interaction patterns of the ETO homologues as well as their …
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Characterisation of PP71 homologues encoded by mammalian cytomegaloviruses
… a comparison of pp71 with the non-human UL82 homologues from simian CMV, baboon CMV, rhesus CMV and chimpanzee CMV, named S82, B82, RH82 and Ch82, respectively. Plasmids expressing all of the UL82 homologues as enhanced yellow fluorescent protein (EYFP) or myc-tagged proteins were constructed …
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The characterization of adaptor protein homologues in Plasmodium falciparum
… and secretory pathways in mammalian cells. Homologues of several adaptor protein subunits are encoded by the parasite genome. The presence of these genes suggests that the parasite experiences clathrin-mediated transport processes. This study reports the cloning and characterization of …
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Transcriptional Control during Quorum Sensing by LuxR and LuxR Homologues
… transcription initiation was also examined. LuxR homologues EsaR of Pantoea stewarti ssp. stewartii, a repressor of known function, and ExpR of Erwinia carotovora subsp. carotovora were also analyzed for their ability to activate the lux operon, as well as to repress transcription from an …
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The synthesis of biologically active oxa-polyamine analogues, homologues and conjugates.
… normal cell function and replication. Analogues, homologues, and derivatives of natural polyamines have been synthesised in order to evaluate the precise role of natural polyamines. In addition many synthesised polyamines have been shown to possess anti-cancer (bis-ethylspermine), anti-parasitic …
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Synthesis of Higher Homologues of Cucurbituril Derivatives and Evaluation of their Supramolecular Properties
… the fact that they are restricted to the smaller homologues, where n = 5 6 and, in some cases, only n = 5. In this thesis, we describe the synthesis of a new family of cyclopentanoQ[n] (n = 5 7) which opens the way to obtaining significant proportions of the substituted higher homologues. In …
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Role of SMU Homologues in Pre-mRNA Splicing During Maize and Arabidopsis Development
… interacts with SMU-2 protein. In addition, human homologues of SMU-1 and SMU-2 proteins wereidentified from human spliceosome. Thus, animal SMU-1 and SMU-2 homologuesappear to play a role in pre-mRNA splicing. Plant SMU-1 and SMU-2 homologueshave not been characterized. This study demonstrated …
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Targeted Disruption of Lynx2 Reveals Distinct Functions for Lynx Homologues in Learning and Behavior
… Ly6SF molecules, I characterize three lynx1 homologues: lynx2, lynx3 and Ly6H. These have different and specific expression patterns in the central and peripheral nervous systems. Importantly, like lynx1, lynx2 and lynx3 are able to bind specific nAChR combinations and modulate their …
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Use of an Inducible Promoter to Characterize Type IV Pili Homologues in Clostridium perfringens
… to express GFP-tagged versions of the TFP ATPase homologues and view them in cells growing on surfaces. We saw that PilB1 and PilB2 co-localized nearly all of the time, while a portion of PilT was independent of the PilB proteins. PilT appeared necessary for the localization of PilB, and it …
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Characterization of the DMCI and Rad51 homologues and the process of meiosis in trichomonas vaginalis
… we induced the expression ofDMCl and Rad51 homologues-key players in Homologous Recombination-using a system of tetracycline induction. We localized DMCl to both the cytoplasm and the nucleus, while Rad51 is localized to the nucleus. We performed a DNA strand exchange that suggests DMCl may …
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Human subjective homologues of established basic emotion correlations in lower mammals: a neuro-psychoanalytic study
Early separation experiences predispose people to depression and depressive episodes are triggered by experiences of social loss. The normal separation response entails a 'protest' phase followed by a 'despair' phase. The affective neuroscience paradigm of Jaak Panksepp identifies two basic emotion …
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Purification de séquences homologues à l'ADN complémentaire de la métallothionéine-I de souris à partir d'une banque génomique de lapin
… de restriction. Par hybridation, les régions homologues à la MT-I de souris et les régions d'ADN répétitif ont été localisées sur les clones. Un clone est plus homologue à la MT-II qu'à la MT-I de souris alors que l'autre est aussi homologue à la MT-I qu'à la MT-II de souris. Des sous-clones …
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Peptide Antisera Generation against Three <em>Chlamydia trachomatis</em> Hsp60 Homologues to Examine Expression of each Hsp60 during Iron Restrictive Growth.
<p>A <em>Chlamydia trachomatis</em> heat shock protein 60kDa (chsp60) exhibits increased expression in response to iron limitation. Genome sequencing revealed three genes encoding chsp60s. The objective of this study was to generate peptide antisera that would selectively recognize each chsp60. The …
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The role of the leukemia-associated ETO homologue repressors in hematopoiesis
… Gene on chromosome 16) were found to be homologues to ETO, all these proteins being transcriptional co-repressors present in complexes together with other co-repressors such as SIN3, N-CoR and SMRT, and histone deacetylases. The objective of this thesis was to investigate the role of the …
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IDENTIFYING HIGHLY CONSERVED PATHOGENICITY GENES IN CHESTNUT BLIGHT AND POWDERY MILDEW FUNGI AS TARGETS FOR NOVEL FORMS OF HOST RESISTANCE
… yielded six suspected pathogenicity genes with homologues in both species. Deletion of these genes by homologous gene replacement was attempted in Cp, with one success, TG4. The TG4-knockout strain showed changes in phenotype and reduced fungal virulence against chestnut. TG4 appears to be a …
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Molecular cloning of three genes encoding SNF1/AMPK protein kinases from Drosophila melanogaster.
… in response to glucose starvation. SNF1 homologues have been found in a number of different organisms and recent molecular and biochemical evidence has revealed that the mammalian AMP-activated protein kinases (AMPKs), known to regulate fatty acid and sterol metabolism in response to …
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Investigation of Non-Linear Chromatographic Retention Behavior for Two Homologous Series of Bis Analytes
… for the bis 3,5-DNB amides is found for the homologues with 5-6 methylene groups in all solvents investigated. In contrast, maximum retention for the bis naproxen amide homologues with 3-8 methylene groups is correlated with the polarity of the mobile phase. Mono analytes of these two series …
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