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Showing 1 to 20 of 274 for “"Homologous recombination"”.

  1. 5-hydroxymethylcytosine and endonuclease G as regulators of homologous recombination

    Vander Zanden, Crystal M., author, Ho, P. Shing, advisor, Peersen, Olve, committee member, Di Pietro, Santiago, committee member, Fisk, Nick, committee memberColorado State University. Libraries2017

    Homologous recombination (HR) is a necessary biological process for all living organisms, and it is especially important for repairing damaged DNA. Improper HR results in DNA damage-related diseases, notably increased likelihood of cancer when HR regulators, such as the human BRCA1 gene, are …

    colostate Repository record

  2. Telomere Specific Homologous Recombination in the Alternative Lengthening of Telomeres

    Whitington, Aric J.2013

    … suggests that ALT cells maintain telomeres by homologous recombination (Reddel 2003 for Review). Groundbreaking work by Oliver Bechter demonstrated that ALT cells and telomerase-positive cells show no difference in the rate of general HR. This study fundamentally shaped our current concept of …

    utswmed Repository record

  3. EXAMINING THE ROLE OF THE XAB2 PROTEIN IN HOMOLOGOUS RECOMBINATION

    Neherin, Kashfia2015

    … or ionizing radiation. For my thesis, I studied homologous recombination (HR), which has two sub-pathways: Homology Directed Repair (HDR) and Single Strand Annealing (SSA). HDR involves strand invasion of a homologous template to prime DNA synthesis; SSA involves annealing of homologous segments …

    csusb Repository record

  4. Diverse outcomes of homologous recombination in the human Y chromosome

    Lange, Julian H. (Julian Hendrik)Massachusetts Institute of Technology2008

    … evolving Y chromosome sequentially suppressed recombination with the X chromosome. While pseudoautosomal regions in the human Y chromosome still participate regularly in allelic homologous recombination, the male-specific region of the Y (MSY) - the only haploid portion of the nuclear genome - …

    mit Repository record

  5. INVESTIGATING THE LINK BETWEEN HOMOLOGOUS RECOMBINATION PROTEIN BRCA2 AND DNA METHYLATION

    PAPAGUDI VENKATRAM, RAJAGOPALUniversità degli Studi di Milano2025

    … normal cells. One such repair mechanism involves homologous recombination (HR) proteins BRCA2 which protects DNA replication intermediates from nuclease-mediated degradation. Emerging evidence demonstrates that HR proteins like BRCA2 co-evolved with the cytosine methylation machinery, suggesting a …

    milano Repository record

  6. Clinical Significance of Homologous Recombination Deficiency Score Testing In Endometrial Cancer

    Hansen, Jean M2017

    <p><strong>Objectives: </strong>Homologous recombination deficiency (HRD) score is related to chemotherapy response in breast and ovarian cancers. The role of HRD is unknown in endometrial cancer. We examined the relationship between HRD score and survival in a cohort of endometrial cancer patients …

    uthsc Repository record

  7. Harnessing mutagenic homologous recombination for in vivo targeted mutagenesis by TaGTEAM

    Finney-Manchester, Shawn P. (Shawn Peter)Massachusetts Institute of Technology2013

    … point mutations occur through error-prone homologous recombination (HR) and depend on resectioning and the error prone polymerase Pol(?). We show that HR is error-prone in this context because of DNA damage checkpoint activation and base pair lesions and use this knowledge to shift the …

    mit Repository record

  8. Homologous Recombination Outcomes of Double-Strand Break- initiated Events in Saccharomyces cerevisiae

    Gamble, Dionna Monique2020

    <p>Homologous recombination (HR) is responsible for repairing otherwise lethal DNA double-strand breaks (DSBs) using a homologous donor template. The work in this dissertation, using the budding yeast Saccharomyces cerevisiae as a model system, focuses on the effect of the initiating DSB and …

    duke Repository record

  9. Homologous recombination and directed differentiation in medaka ES cells: Development of vector systems

    LU WENQING2006

    … fast assay of relative cellular activities for homologous recombination versus random integration. In this system, a cell that has undergone a homologous recombination has red cytoplasm, while cell with a nonhomologous recombination possesses a green nucleus. The roles of important DNA-repairing …

    nus Repository record

  10. Characterisation of factors that regulate homologous recombination and antigenic variation in Trypanosoma brucei

    Hartley, Claire LouiseUniversity of Glasgow2008

    … and occur primarily by the recombination of VSG genes, selected from an enormous silent archive, into specialised expression sites. It has been previously shown that such VSG switching is a form of homologous recombination, as mutation of RAD51 and a related gene, RAD51-3, …

    glasgow Repository record

  11. Functional Analysis of the Human SMC5/6 Complex in Homologous Recombination and Telomere Maintenance

    Potts, Patrick Ryan2010

    … the repair of DNA double-strand breaks (DSBs) by homologous recombination (HR). The SMC1/3 cohesin complex promotes HR by localizing to DSBs where it holds sister chromatids in close proximity to allow HR-induced strand invasion and exchange. The SMC5/6 complex is also required for DNA repair, but …

    utswmed Repository record

  12. Homologous Recombination deficiency classification and PARP inhibitor response of reference-free colorectal cancer samples

    Medico, Enzo, Bardelli, Alberto, Corti, GiorgioUniversità degli Studi di Torino2024

    unito Repository record

  13. Regulation of Rad51D In Homologous Recombination Dna Repair by Alternative Splicing and Ubiquitin Modification

    Yard, Brian David

    … One of the most critical DNA repair pathways is homologous recombination (HR), which is responsible for error-free repair of DNA double-stranded breaks and interstrand crosslinks. Understanding the processes that regulate HR will provide new insights into carcinogenesis and potentially identify …

    south-carolina Repository record

  14. Mitotic homologous recombination at engineered repeats in S. cerevisiae and in novel transgenic mice

    Hendricks, Carrie A. (Carrie Anne), 1975-Massachusetts Institute of Technology2003

    Although homologous recombination provides an efficient means for repairing and tolerating DNA damage, mitotic recombination between misaligned sequences can lead to loss of genetic information (e.g. deletions, translocations and loss of heterozygosity). Given that such genetic changes may promote …

    mit Repository record

  15. BRCA1 and CtIP Are Both Required to Recruit Dna2 at Double-Strand Breaks in Homologous Recombination

    Nguyen, Ngoc HoaKyoto University2016

    kyoto Repository record

  16. The role of TvTrxR in drug resistance and characterization of TvRad51 in homologous recombination in Trichomonas vaginalis

    Hopper, Melissa2018

    … Resistance and Characterization of TvRad51 in Homologous Recombination in Trichomonas vaginalis Abstract By Melissa Hopper University of the Pacific 2016 In recent years, prevalence of metronidazole-resistant cases of Trichomonas vaginalis has been on the rise. With nearly 10% of strains …

    u-pacific Repository record

  17. The impact of age, exposure and genetics on homologous recombination at the engineered repeat sequence in mice

    Wiktor-Brown, Dominika MMassachusetts Institute of Technology2007

    Mitotic homologous recombination is a critical pathway for the repair of DNA double-strand breaks and broken replication forks. Although homologous recombination is generally error-free, recombination between misaligned sequences can lead to deleterious sequence rearrangements, and conditions that …

    mit Repository record

  18. Fluorescent detection of homologous recombination reveals the impact of genetic, physiological, and environmental factors on genomic stability

    Sukup Jackson, Michelle RMassachusetts Institute of Technology2013

    … cellular toxicity. DSBs are repaired via mitotic homologous recombination (HR), non-homologous end-joining (NHEJ) or microhomology-mediated end-joining (MMEJ). Here we use the Fluorescent Yellow Direct Repeat (FYDR) mouse to examine these pathways. Specifically, we crossed FYDR mice with mice …

    mit Repository record

  19. Functional analyses of hTel2 and TRF2 deltaB: Insights Into the Role of a New DNA Damage Pathway and Homologous Recombination in Mammalian Telomere Function

    Wang, Richard Chih-Chien

    … and phenotypes. TRF2 protects telomeres from non-homologous end joining (NHEJ), possibly through the formation of a t-loop structure. A mutant allele of TRF2, TRF2AB, retained the ability to suppress NHEJ but induced dramatic deletions of telomeric DNA. This catastrophic telomere shortening was …

    rockefeller Repository record

  20. Chemosensitization of Hepatocellular Carcinoma to Gemcitabine By Non-Invasive Radiofrequency Field-Induced Hyperthermia

    Raoof, Mustafa2012

    … solid tumors. In this study, we evaluated homologous recombination repair of gemcitabine-stalled replication forks as a potential mechanism contributing to resistance. We also studied the effect of hyperthermia on homologous recombination pathway to explain the previously reported synergy …

    uthsc Repository record

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