Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"Homologous Proteins"”.
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Statistical Analysis of Biological Interactions from Homologous Proteins
… in two different crystal forms by divergent proteins is very likely to be biologically important. The interface data not only provide new interaction templates for computational modeling, but also provide more accurate data for training sets and testing sets in data-mining research to predict …
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Computational approaches to modeling the conserved structural core among distantly homologous proteins
… produced sequence data for huge quantities of proteins, and 3-D structural information for a much smaller number of proteins. We introduce several algorithms that make use of the limited available structural information to classify and annotate proteins with structures that are unknown, but …
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Calculating the structure-based phylogenetic relationship of distantly related homologous proteins utilizing maximum likelihood structural alignment combinatorics and a novel structural molecular clock hypothesis
… relationships and homology of species, proteins, or genes. Homology modeling, ligand binding, and pharmaceutical testing all depend upon the homology ascertained by dendrograms. Regardless of the specific algorithm, all dendrograms that ascertain protein evolutionary homology are …
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BIOINFORMATIC ANALYSIS OF A MAMMALIAN BIP GENE FOR INSERTION INTO GREEN ALGAE AND COMPARISON OF ITS POSSIBLE EFFECTS ON THE SYNTHESIS OF A MAMMALIAN ANTIBODY
… 78 (grp 78), also known as BiP. The selected homologous proteins originate from organisms of infinitely diverse genera. Comparisons of protein sequence yielded the first clues of a common ancestry among these proteins. Furthermore, protein molecular weights, isoelectric points, N-terminal …
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Aquaporin 3 Water Channel Protein Gene Expression in Squalis Acanthias Dogfish Shark
Aquaporins are a family of membrane proteins that provide channels for the rapid movement of water molecules and some small solutes across the cellular membrane. Since the discovery of the first water channel protein, hundreds of homologous proteins have been found in all forms of life and much has …
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A mutational analysis of the roles of cytoplasmic domains of the gonadotropin-releasing hormone receptor in coupling and internalization
… receptor (GPCR) family is the largest group of homologous proteins in the human genome. GPCRs are of prime physiological and medical importance as the actions of a wide range of hormones and drugs are mediated by these receptors. The gonadotropin-releasing hormone (GnRH) receptor is a member of …
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Studies on Combining Sequence and Structure for Protein Classification
… is to develop a better understanding of how proteins evolve different structures and functions. A large scale protein clustering can provide a useful platform to identify such principles of protein evolution. Manual classification schemes accurately group homologous proteins, but they are …
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Improving Profile Similarity Search and Alignment of Protein Sequences
… predict protein function is to detect homologs. Homologous proteins tend to possess conserved sequence motifs, the same structure folds, and similar functional sites. Current sequence-based homology search methods are still unable to detect many similarities evident from protein spatial …
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Cloning, Expression, and Characterization of Ara h 3, a Major Peanut Allergen
… States, there are three immunodominant allergic proteins accountable for patient sensitization to peanut, Arachis hypogea 1, 2, and 3 (Ara h 1, Ara h 2, Ara h 3). Therefore, research into why peanuts are more allergic than other foods that have homologous proteins is critical and may be obtained …
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Structural insight into the assembly of iron-sulfur clusters and their function in radical generation
… loop, consistent with structures solved of homologous proteins. The length of this loop is thought to restrain the active site cysteine, interfering with its ability to affect catalysis. Our results are consistent with the theory that this cysteine desulfurase requires an accessory protein …
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The Role of Insig-Mediated Cholesterol Homeostasis in Mouse Hair Development
Insig-1 and Insig-2, two very homologous proteins, are indispensable for feedback inhibition of cholesterol biosynthesis. Mice null for both Insigs drastically overproduce cholesterol and its precursor sterol intermediates and exhibit many developmental abnormalities such as cleft palate. In this …
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Characterisation of potential Holliday junction resolvases in Trypanosoma brucei
… Holliday junctions are an essential part of homologous recombination, which is used for DNA repair and for the crossover of DNA. Identifying T. brucei proteins which act as Holliday junction resolvases are potential candidate targets for inhibiting VSG switching. In this project, …
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Energetics and Structural Aspects of Cation-Coupled Drug Transport by NorM Multidrug Transporters
NorM multidrug transport proteins belong to the multiple antibiotics and toxins extrusion (MATE) family of secondary active transporters. Members of this family are present across all species including bacteria, plants and humans. In bacteria, their over-expression can lead to antibiotic …
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Combinatorial biosynthetic pathway engineering for microbial production of biofuels
… enzyme combinations by creating a library of homologous proteins from the pathway. A second strategy investigated engineering all of the proteins in the pathway simultaneously. The improved pathway was assessed based on specific growth rate on cellobiose, with the final mutant exhibiting a 42% …
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Improving the dietary management of orofacial granulomatosis
… dietary avoidance of raw plant foods containing homologous proteins that cross react with these pollens.<br/>The aim of this thesis was to improve the dietary management of patients with OFG.<br/>A medical notes review (n=207) outlined the clinical presentation and provided insight into differing …
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Biophysical and structural studies of novel F420-dependent oxidoreductases in Mycobacterium tuberculosis
… tuberculosis (Mtb) genome encodes hundreds of proteins with unknown or putative function based on sequence similarity to characterised proteins. Incomplete knowledge of Mtb functional genomics undermines efforts to understand the complex biological repertoire of this deadly human pathogen. …
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Genome analysis of Campylobacter concisus strains from patients with inflammatory bowel disease and gastroenteritis
… GS2-specific genes. CRISPR-Cas system-associated proteins were only found in some GS2 strains but completely absent from GS1 strains. These results suggest that the two C. concisus genomospecies may differ in their virulence potential and the ability to adapt to different environments. In Chapter …
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Regulation of cellular growth and identification of stromal gene signatures in breast cancer
… the cell can form cytoplasmic complexes of proteins and RNAs, called stress granules, to inhibit translation of proteins unnecessary for the cell during harmful conditions and focus translation on stress-related proteins. In neuroblastoma and breast cancer cell lines, we have found that the …
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The Structural Characterization and Bioactivity Assessment of Nonspecific Lipid Transfer Protein 1 (nsLTP1) from Caraway (Carum Carvi) Seeds
… no effort has been made to study caraway proteins and their potential pharmacological properties, including nonspecific lipid transfer protein (nsLTP), necessitating further research. The current study aimed to characterize nonspecific lipid transfer protein 1 (nsLTP1) from caraway seed, …
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Integration and analysis of protein evolutionary relationships and small molecule bioactivity data
Interactions of small organic molecules and proteins have been studied extensively in the search of therapeutic drugs. Historically, the interaction partners have been attributed to separate scientific disciplines: small organic molecules to the domain of chemistry, proteins to the domain of …
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