Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Homodimerisation"”.
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The structure of the cytoplasmic dynein tail
… is important for both cargo binding as well as homodimerisation of the DHC, which is necessary for processive movement. Previous studies suggest that the DLCs play an important role in homodimerisation, but it remains unclear how else the DHCs are held together. Using S. cerevisiae as a model …
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Self-Assembly of Calix[4]Arene Amine Derivatives
… namely the heterodimerisation form and the homodimerisation form. It is believed that due to the loss of the t-butyl groups early in the synthesis that this allows extra flexibility in the calix[4]arene unit, thereby allowing it to alternate between its different conformers. Metal ion …
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Structure-function studies of the Parkinsonism-linked protein DJ-1
… on how disease-linked mutations that impairs homodimerisation could disrupt the metal binding site. In the second part of this dissertation, we sought to determine the impact of a Parkinsonism-linked A107P mutation on DJ-1 structure and glyoxalase activity. The A107P variant abrogates the …
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Investigating the role of curvature on the formation and thermal transformations of soot
… Homogeneous nucleation was considered with homodimerisation energies with one or two internal pentagonal rings within cPAH found to be comparable in energy to flat PAH (fPAH) homodimers of similar weight, with more pentagons reducing the binding energy. Ion-induced nucleation was considered …
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Prostaglandin EP3 receptor signalling as a contributor to sex differences in stress-related disorders mediated by the locus coeruleus
… assays demonstrated reduced EP3 receptor homodimerisation in CCI females, suggesting impaired receptor stability or availability. Functional assays further showed that intra-LC sulprostone decreased cAMP levels in CCI males but increased them in females, indicating sex-specific alterations …
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Localization and dimerization of the ABC half transporter rAbcb6 as compared to rAbcb7
Abcb6 (rAbcb6) ist ein ABC-Halbtransporter der ABCB-Subfamilie und benötigt einen Dimerisationspartner, um seine Funktion ausüben zu können. Das Hauptziel dieser Arbeit war die Identifizierung eines Dimerisationspartners für rAbcb6. Aufgrund der Sequenzhomologie zwischen menschlichem ABCB7 und …